Antiarthritic activity of Abrus precatorius in Albino rats

The aim of this study was to evaluate the antiarthritic activity of water extract of leaves of Abrus precatorius (AP) on arthritis induced model in rats. Arthritis was induced in male albino Wister rats by injection of croton oil (0.1 ml) into the left foot pad of the animals. Treatment with AP at 200 and 400 mg/kg dose and standard indomethacin (0.3 mg/kg) was started on the same day and continued up to day 12. The paw volume was measured and antiathritic activity evaluated on days 1, 5, 12 and 21 after treatment. The extract of AP produced reduction in the inflammation of the paw produced due to croton oil. The antiarthritic action started on day 5 and continued till day 12 and the activity was comparable to that of the standard on both days. AP significantly inhibited adjuvant induced arthritis and has significant ant-inflammatory effect (

Evaluation of the anti-inflammatory activity of extract of Abrus precatorious

The anti-inflammatory activity of the extract of Abrus precatorius was investigated. Inflammatory response was induced by topical application of croton oil dissolved in suitable vehicle on the rat ear. After 6 hrs, cutting out the ear quantified the response. The cut ear was weighed and the increase in weight relative to controls evaluated. Extract of Abrus precatorius when co applied with croton oil to the rat ear produced a reduction in the inflammatory response produced when croton oil alone was applied to the rat ear. The extract produced 67.10 ± 2% reduction of the inflammatory response produced by croton oil alone, which was however lower than the 71.1 ± 2% reduction of the inflammatory response produced by acetyl salicylic acid. This finding suggests that extract of Abrus precatorius exhibits anti-inflammatory activity and may explain the usefulness of the leaves of this plant in the treatment of inflammatory disease conditions by traditional healers

Effect of extract of Abrs Precatorius on blood glucose concentration of alloxan induced diabeticc albino westar rats

The effect of leaf extract of Abrus precatorius on blood glucose level of alloxan- induced diabetic albino wistar rats was evaluated. Experimental animals received daily oral administration of extract of Abrus precatorius for 14 days. The effect of 200 mg/kg dose was studied during the treatment period. There was a significant reduction in blood glucose level (p< 0.05) with the mean blood glucose level of the different groups being 5.0 ± 0.33for normal control, 7.0 ± 0.40 for diabetic control group and 4.0 ± 0.24 for diabetic treated group. The findings of this study suggest that extract of Abrus precatorius has hypoglycemic effect

Antiarthritic Activity of Vernonia amygdalina in Albino Rats

The aim of this study was to evaluate the antiarthritic activity. The water extract of leaves of Vernonia amygdalina (V.A.) on arthritis induced model in rats. Arthritis was induced in male Wistar albino rats by injection of croton oil (0.1ml) into the left foot pad of the animals. Treatment with V.A. (200 and 400mg/kg b.w.). The standard anti-inflammatory drug, indomethacin (0.3mg/kg) was started on the same day and continued up to day 12. The paw volume was measured on day 1, 5, 12 and 21 for both the paws and antiathritic activity was evaluated. The extract of V.A produced reduction in the volumes of the paw produced by croton oil. The antiarthritic action started on day 5 and continued till day 12 and the activity was comparable to that of the standard drug within the treatment period. V.A. significantly inhibited adjuvant induced arthritis and had significant ant-inflammatory effect (P&le;0.05).Keywords: Vernonia amygdalina, Antiarthritic Effect, Croton Oil

Effect of leaf extract of Pseudocedrela kotchyion blood glucose concentration of alloxan induced diabetic albino wister rats

The effect of leaf extract of Pseudocedrela kotchi (PK) on blood glucose of alloxan induced albino wistar rats was evaluated. Experimental animals received daily oral administration of extract of Pseudocedreala kotchi for 14 days. The effect of 200 mg/kg dose was studied during the treatment period. There was a significant reduction in blood glucose concentration (p< 0.05) with the mean blood glucose level of the different groupsbeing 5.5 ± 0.33 mmol/L for normal control, 7.0 ± 0.40 mmol/L for diabetic control group and 4.8 ± 0.24 mmol/L for diabetic treated group. The findings of this study suggest that extract of Pseudocedreala kotchi has hypoglycemic effect

Preliminary evaluation of the anti-inflamatory activity of extract of Vernonia Amygdalina

The anti-inflammatory activity of the extract of Vernonia amygdalina (V.A) was investigated. Inflammatory response was induced by topical application of croton oil dissolved in suitable vehicle on the rat ear. After 6hrs, the ear was exised, weighed and the increase in weight relative to controls evaluated. Extract of V.A. when co applied with croton oil to the rat ear produced a reduction in the inflammatory response produced when croton oil alone was applied. The extract produced 67.10 ± 2% reduction of the inflammatory response produced by croton oil alone. This was however, lower than the 71.1 ± 2% reduction of the inflammatory response produced by acetyl salicylic acid, a standard anti-inflammatory agent. This finding suggests that extract of V.A. exhibits antiinflammatoryactivity and may explain the usefulness of the leaves of this plant in thetreatment of inflammatory disease conditions by traditional medical practitioners

A study of the histaminic activity of extract of Mucuna pruriens

This study investigated the pharmacological activity of the principle from the spines of the seed pods of Mucuna pruriens using contraction of guinea pig ileum as index of pharmacological activity. The active principle was extracted with 0.0015 M NaCl. Muscle strips of guinea pig ileum were prepared and contractile responses were measured using a Kymograph. Two sets of experiments were conducted viz: the contraction of the ileum in the presence of different concentrations of histamine, 2 – methylhistamine and the extract of Mucuna pruriens and the contractile response of the ileum in the presence of different concentrations of the extract and antagonists – diphenhydramine, atropine and methysergide. Mucuna pruriens extract, 2 – methylhistamine and histamine produced dose dependent contraction of guinea pig ileum (Extract ED50 = 13.0 ìg/ml; 2 – methylhistamine ED=50-8.5 ìg/ml and Histamine ED50=10 ìg/ml). Diphenhydramine, an H1 antagonist competitively blocked the contractile response of the extract and coadministration of the extract either with different doses of antimuscarinic agent atropine or 5 – hydroxytryptamine blockingagent, methysergide did not alter the extract - induced contractile response of the guinea pig ileum. These results demonstrate that the spines of Mucuna pruriens possess histamine activity which may contribute to its itching and painful irritation effects

Chronic renal failure secondary to polysubstance misuse

Chronic Renal Failure [CRF] is a progressive irreversible deterioration in renal function with a spectrum ranging from biochemical abnormalities [azotemia] to clinically evident abnormalities [uraemia] and end stage renal disease [ESRD]. The purpose of this paper is to highlight the significance of rare causes of CRF in the management of such patients. A case of a 26 year old male who had CRF with the only identifiable risk factor being abuse of recreational drugs alongside a review of relevant literature was studied. The patient presented with symptoms and signs in keeping with long standing impairment of renal function with causes traceable to his chronic abuse of cannabis and heroine. In the diagnosis, management, and follow-up of patients with chronic kidney disease, the importance of a detailed social history and life style modification cannot be overemphasized. We therefore recommend that appropriate diagnosis of CRF be made whenever it occurs and in the case of substance misuse, appropriate treatment given in that direction to relieve the disease