Studies on the denaturation of antibody: II. The effect of protein concentration on the rate of denaturation of diphtheria antitoxin by urea

The specific rate of inactivation of antitoxin in urea solutions, as measured by the Römer neutralization test with toxin, has been shown to be independent of the concentration of protein under the conditions studied. The amount of precipitate obtained in the quantitative precipitation test with toxin, however, increases greatly with increasing protein concentration during denaturation. The time during which the protein concentration is important in this respect has been shown to be the interval in which the urea is being dialyzed from the solutions. The meaning of the results is discussed

Optimality in Quantum Data Compression using Dynamical Entropy

In this article we study lossless compression of strings of pure quantum states of indeterminate-length quantum codes which were introduced by Schumacher and Westmoreland. Past work has assumed that the strings of quantum data are prepared to be encoded in an independent and identically distributed way. We introduce the notion of quantum stochastic ensembles, allowing us to consider strings of quantum states prepared in a more general way. For any identically distributed quantum stochastic ensemble we define an associated quantum Markov chain and prove that the optimal average codeword length via lossless coding is equal to the quantum dynamical entropy of the associated quantum Markov chain

Structuring the decision process : an evaluation of methods in the structuring the decision process

This chapter examines the effectiveness of methods that are designed to provide structure and support to decision making. Those that are primarily aimed at individual decision makers are examined first and then attention is turned to groups. In each case weaknesses of unaided decision making are identified and how successful the application of formal methods is likely to be in mitigating these weaknesses is assessed

Studies on the denaturation of antibody. IV. The influence of pH and certain other factors on the rate of inactivation of Staphylococcus antitoxin in urea solutions

In previous work on the denaturation of antibody, studies have been made of some of the factors influencing the inactivation of diphtheria antitoxin in urea solutions (1, 2). A quantitative formulation of a simple kinetic theory was found to fit satisfactorily the experimental data and to offer a reasonable explanation of the deviation of the inactivation from simple first order behavior (2). In the present work we have studied the inactivation of Staphylococcus antitoxin, investigating the influence of certain new factors on the rate and course of the over-all reaction, with a view toward gaining further insight into the mechanism of the reactions, and reinvestigating the influence of pH, a factor studied previously with diphtheria antitoxin, in order to test the applicability of the proposed kinetic mechanism to different antibodies

Adaptations and accommodations: The use of the WAIS III with people with a Learning Disability

Evidence of significant impairment in cognitive functioning has always been one of the main criteria of a learning disability (Pulsifer, 1996) and intellectual assessment is, therefore, one of the tasks of clinical psychologists working within learning disability services. Such assessments are commonly used to help establish of an individual’s cognitive strengths and weaknesses, support needs and more specifically, to help determine if an individual falls within the remit of learning disability services (McKenzie & Murray, 2002, Evers & Hill, 1999). Intellectual assessments also have important implications in terms of mental health legislation, accessing benefits and services and informing legal decision-making processes (British Psychological Society, 2001, McKay, 1991). It is, therefore, crucial that the assessments are valid, reliable and used only by appropriately trained and qualified professionals. In Britain, it is emphasised that assessing an individual’s intellectual functioning requires an individually administered, standardised psychometric assessment which is reliable and valid (British Psychological Society, 2001), while in America professional mandates, such as the Standards for Educational and Psychological Testing (AERA,APA & NCME, 1985) highlight the need for high standards of administrative accuracy from psychologists. The Wechsler Adult Intelligence Scales - Third Edition (Wechsler, 1998) are commonly used in intellectual and neuropsychological assessment and are considered to be valid, reliable and well-standardised (Groth-Marnat et al, 2000). The Wechsler Scales have a long history and have undergone a number of revisions with the most recent being in 1997 with the development of the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III). The purpose of these revisions was to insure that the standardisation sample was representative of current demographics and performance, to update the subtests, incorporate new subtests, and refine the instructions and test materials. Each revision has been well researched and validated (Groth Marnat et al, 2000)

High-capacity preconscious processing in concurrent groupings of colored dots.

Grouping is a perceptual process in which a subset of stimulus components (a group) is selected for a subsequent-typically implicit-perceptual computation. Grouping is a critical precursor to segmenting objects from the background and ultimately to object recognition. Here, we study grouping by color. We present subjects with 300-ms exposures of 12 dots colored with the same but unknown identical color interspersed among 14 dots of seven different colors. To indicate grouping, subjects point-click the remembered centroid ("center of gravity") of the set of homogeneous dots, of heterogeneous dots, or of all dots. Subjects accurately judge all of these centroids. Furthermore, after a single stimulus exposure, subjects can judge both the heterogeneous and homogeneous centroids, that is, subjects simultaneously group by similarity and by dissimilarity. The centroid paradigm reveals the relative weight of each dot among targets and distractors to the underlying grouping process, offering a more detailed, quantitative description of grouping than was previously possible. A change detection experiment reveals that conscious memory contains less than two dots and their locations, whereas an ideal detector would have to perfectly process at least 15 of 26 dots to match the subjects' centroid judgments-indicating an extraordinary capacity for preconscious grouping. A different color set yielded identical results. Grouping theories that rely on predefined feature maps would fail to explain these results. Rather, the results indicate that preconscious grouping is automatic, flexible, and rapid, and a far more complex process than previously believed