8 research outputs found
Additional file 1: of Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases
Sensitivity data for MMP and TIMP luminex assays. MMP/TIMP ratios in BAL in COPD and PLF subjects. (DOCX 171Â kb
Additional file 1: of Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease
Supplemental Data. Supplemental supporting figures (Figures S1âS10) and tables (Tables S1-S8). (PDF 4193Â kb
DNA methylation profiling in human lung tissue identifies genes associated with COPD
<p>Chronic obstructive pulmonary disease (COPD) is a smoking-related disease characterized by genetic and phenotypic heterogeneity. Although association studies have identified multiple genomic regions with replicated associations to COPD, genetic variation only partially explains the susceptibility to lung disease, and suggests the relevance of epigenetic investigations. We performed genome-wide DNA methylation profiling in homogenized lung tissue samples from 46 control subjects with normal lung function and 114 subjects with COPD, all former smokers. The differentially methylated loci were integrated with previous genome-wide association study results. The top 535 differentially methylated sites, filtered for a minimum mean methylation difference of 5% between cases and controls, were enriched for CpG shelves and shores. Pathway analysis revealed enrichment for transcription factors. The top differentially methylated sites from the intersection with previous GWAS were in <i>CHRM1, GLT1D1</i>, and <i>C10orf11</i>; sorted by GWAS <i>P</i>-value, the top sites included <i>FRMD4A, THSD4</i>, and <i>C10orf11</i>. Epigenetic association studies complement genetic association studies to identify genes potentially involved in COPD pathogenesis. Enrichment for genes implicated in asthma and lung function and for transcription factors suggests the potential pathogenic relevance of genes identified through differential methylation and the intersection with a broader range of GWAS associations.</p
Additional file 2: of Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease
Supplemental Table S5. Table containing Sherlock results. (PDF 68Â kb
Additional file 1: of Genome-wide association study of subclinical interstitial lung disease in MESA
Online Data Supplement for âGenome-wide association study of subclinical interstitial lung disease in MESAâ. (DOCX 14799 kb
Additional file 1: Table S1. of Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study
IRB Approval and Protocol Numbers for COPDGene. (DOCX 26 kb
Additional file 1 of Pectoralis muscle area and mortality in smokers without airflow obstruction
Figure S1. Plot of the pectoralis muscle area (PMA) to paravertebral muscle area (PVMA). The relationship between the muscle groups was significant (R2 = 0.44, P < 0.0001). Table S1 Baseline characteristics of at-risk smokers by quartile of PVMA (N = 3705). (DOCX 207 kb