Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)

The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death. Prompt early initiation of sequenced multidrug therapy (SMDT) is a widely and currently available solution to stem the tide of hospitalizations and death. A multipronged therapeutic approach includes 1) adjuvant nutraceuticals, 2) combination intracellular anti-infective therapy, 3) inhaled/oral corticosteroids, 4) antiplatelet agents/anticoagulants, 5) supportive care including supplemental oxygen, monitoring, and telemedicine. Randomized trials of individual, novel oral therapies have not delivered tools for physicians to combat the pandemic in practice. No single therapeutic option thus far has been entirely effective and therefore a combination is required at this time. An urgent immediate pivot from single drug to SMDT regimens should be employed as a critical strategy to deal with the large numbers of acute COVID-19 patients with the aim of reducing the intensity and duration of symptoms and avoiding hospitalization and death

Remote Sensing and GIS Techniques for Selecting a Sustainable Scenario for Lake Koronia, Greece

During recent decades, Lake Koronia has undergone severe degradation as a result of human activities around the lake and throughout the basin. Surface and groundwater abstraction and pollution from agricultural, industrial, and municipal sources are the major sources of degradation. Planning a restoration project was hampered by lack of sufficient data, with gaps evident in both spatial and temporal dimensions. This study emphasized various remote sensing and geographic information system techniques, such as digital image processing and geographic overlay, to fill gaps using satellite imagery and other spatial environmental, hydrological, and hydrogeological data in the process of planning the restoration of Lake Koronia, following Ramsar guidelines. Current and historical remote sensing data were used to assess the current status and level of degradation, set constraints and define the ideotype for the restoration, and, finally, define and select the best restoration scenario