IPTp reporting forms.

<p>IPTp reporting forms.</p

Facility characteristics.

<p>Facility characteristics.</p

The antenatal care visit process.

<p>The antenatal care visit process.</p

Facility B IPTp2 DHIS data 2015.

<p>Facility B IPTp2 DHIS data 2015.</p

Map of the study area and schools.

<p>Schools assigned to the IST intervention are shown in blue and schools assigned to the control group are shown in yellow. Insert shows the location of the study site in Kenya.</p

Study design diagram.

<p>This figure depicts the randomisation procedures.</p

Baseline characteristics of 5,233 study children in the 50 control and 51 IST intervention schools.

a<p>Percent of non-missing children in each study group presented for categorised data. For continuous data mean (SD) [min,max] is presented.</p>b<p>All characteristics have less than 2% missing data with the exception of following indicators (reported as control/intervention): stunted and thin both (138/248 [5.5/9.2%] missing), underweight (1,538/1,744 [61.0/64.4%] missing), net use last night (661/840 [26.2/31.0%] missing).</p>c<p>In Class 1, mean (SD) for age is: 7.8 (1.7) and in Class 5, mean (SD) for age is:12.5 (1.6).</p>d<p>Percentages of treated nets and children sleeping under a net last night are presented only for those children who were reported as usually sleeping under a net.</p>e<p>Study endpoints have less than 5% missing data at baseline with the exception of the following (reported as control/intervention): Hb (147/255 [5.8/9.4%] missing), <i>P. falciparum</i> infection (274 [10.1%] missing in intervention group), class 5 attention (79/72 [6.1/5.2%] missing).</p>f<p>Coefficient of variation (k) estimated for binary outcomes using available baseline (i.e., only using data from IST schools for <i>P. falciparum</i>) and interclass correlation coefficient (ICC) estimated for continuous outcomes using baseline measures.</p>g<p>Not measured at baseline in the control group.</p>h<p>Presented as mean (SD) [min,max].</p>i<p>In class 1 sustained attention was measured by the “pencil tap test” and in class 5 sustained attention was measured by the “two digit code transmission test.”</p

Effect of the IST intervention at 9- and 24-months follow-up on educational achievement (spelling and arithmetic) outcomes for younger (class 1) and older (class 5) children.

<p><a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001594#s3" target="_blank">Results</a> presented (i) for all children with outcome data (unadjusted) and (ii) for those with baseline measurements of each outcome and accounting for age, sex, and stratification effects (adjusted) as the primary pre-specified analysis. <i>N</i>, number of children eligible for follow-up (not withdrawn or deceased). Adjusted: for baseline age, sex, school mean exam score and literacy group (to account for stratification) and baseline measure of the outcome, where available; unadjusted: all children with outcome measures, not adjusted for any baseline or study design characteristics.</p>a<p>Mean difference (intervention-control) for scores on spelling and arithmetic are obtained from GEE analysis accounting for school-level clustering.</p>b<p>Mean score and SD at follow-up.</p>c<p>The same class 1 spelling task was given at baseline, 9- and 24-months follow-ups, with different words used for the 24-month follow-up.</p>d<p>Same addition task conducted at 9-months follow-up and at baseline, hence baseline adjustment is for the same task.</p>e<p>The same class 5 spelling task was given at baseline, 9- and 24-months follow-ups, with different words used for the 24-month follow-up.</p>f<p>Same arithmetic task conducted at baseline, 9- and 24-months follow-ups, with different sums used for the 24-month follow-up.</p>g<p>Addition task conducted at baseline and arithmetic task containing addition, subtraction, multiplication, and division conducted at 24-months follow-up, hence baseline adjustment for different task.</p

Effect of the IST intervention at 9- and 24-months follow-up on sustained attention outcomes for younger (class 1) and older (class 5) children.

<p><a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001594#s3" target="_blank">Results</a> presented (i) for all children with outcome data (unadjusted) and (ii) for those with baseline measurements of each outcome and accounting for age, sex, and stratification effects (adjusted) as the primary pre-specified analysis. <i>N</i>, number of children eligible for follow-up (not withdrawn or deceased). Adjusted: for baseline age, sex, school mean exam score and literacy group (to account for stratification), and baseline measure of the outcome, where available; unadjusted: all children with outcome measures, not adjusted for any baseline or study design characteristics.</p>a<p>Mean difference (intervention-control) are obtained from GEE analysis accounting for school-level clustering.</p>b<p>Mean score and SD at follow-up.</p>c<p>Pencil tap test was conducted at baseline and single digit code transmission task was conducted at 9- and 24-months follow-ups.</p>d<p>Double digit code transmission was conducted at baseline and both follow-ups.</p

Effect of the IST intervention at 12- and 24-months follow-up on health outcomes anaemia and <i>P. falciparum</i> prevalence for study children.

<p><a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001594#s3" target="_blank">Results</a> presented (i) for all children with outcome data (unadjusted) and (ii) for those with baseline measurements of each outcome and accounting for age, sex, and stratification effects (adjusted) as the primary pre-specified analysis. <i>N</i>, number of children eligible for follow-up (not withdrawn or deceased). Adjusted: for baseline age, sex, school mean exam score and literacy group (to account for stratification), and baseline measure of the outcome, where available; unadjusted: all children with outcome measures, not adjusted for any baseline or study design characteristics.</p>a<p>Risk ratios (intervention/control) presented for binary outcomes (anaemia and <i>P. falciparum</i> prevalence) and are obtained from GEE analysis accounting for school-level clustering.</p>b<p>Number and percentage with outcome.</p>c<p>Age-sex specific anaemia was defined using age and sex corrected WHO thresholds of Hb: <110 g/l in children under 5 years; <115 g/l in children 5 to 11 years; <120 g/l in females 12 years and over and males 12 to 14.99 years old; and <130 g/l in males ≥15 years. All female adolescents are assumed to not be pregnant.</p>d<p>Not including baseline <i>P. falciparum</i> infection.</p