Haplotype Block Structure of the <i>PRKCA</i> Gene in Finnish and Canadian Populations

<p>(A) shows the block structures of the <i>PRKCA</i> gene (between SNPs rs3764402 and rs4791037) in 211 Finnish MS families; (B), in the 554 Canadian MS families. The haplotype blocks were created using the solid line of LD of the Haploview program, version 3.2 [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020042#pgen-0020042-b027" target="_blank">27</a>]. The SNPs providing strongest evidence for association to MS in <i>PRKCA</i> in Finns and Canadians (rs887797, rs2361491 and rs2078153, rs1860984, respectively) are marked with black arrows, SNPs used in Haploview version 3.2 [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020042#pgen-0020042-b027" target="_blank">27</a>] haplotype analysis in 211 Finnish families are indicated with boxes, and those used in the two SNP genotype combinations are indicated with a white arrowhead with the letter H and the rs-numbers given above.</p

Schematic Representation of the MS Locus on Chromosome 17q24

<p>Positions of the SNPs used in stages I, II, and III are shown with arrowheads. Grey arrowheads indicate SNPs showing evidence for association: stage I, <i>p</i> < 0.05; stage II, <i>p</i> < 0.01. SNP rs887797 showing evidence for association in the two independent Finnish study sets (Study sets I and II) is shown with a black arrow. The horizontal bar indicates the position of the critical MS region identified by haplotype analysis in our previous study [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020042#pgen-0020042-b021" target="_blank">21</a>]. The positions of the genes mapping to the locus are shown as boxes below.</p