Univariate analysis of viruses detected in matched case control pairs enrolled during 2001.

<p>Two-tailed univariate analysis by McNemar's test for correlated proportions comparing matched case-control pairs concordant and discordant for exposure to an individual virus.</p>*<p>Viruses detected from 186 cases and 186 age-matched paired controls in which recognized bacterial pathogens were not detected.</p>†<p>OR, odds ratio.</p>‡<p>CI, 95% confidence interval.</p>§<p>Multiple viruses in 20 different combinations.</p>∥<p>Multiple viruses in 7 different combinations.</p

Phylogenetic analysis of parvoviruses: Maximum likelihood dendrogram (bootstrapped, 1,000 replicates) based on full-length parvovirus genome sequence (nucleotide) alignments.

<p>Approximately 100–200 nucleotides are absent from each termini of the HBoV2, HBoV3, and HBoV sequences.</p

Genome similarity plot of HBoV3-W471 against HBoV (black line, DQ000495) and HBoV2-W153 (grey line) showing percentage similarity along the aligned genomes (SimPlot 3.2, 2-parameter (Kimura) distance model, window size is 300 bp, step size is 30 bp).

<p>Approximate recombination sites are indicated by the crossover of the sequence most similar to HBoV3-W471 at positions 200 and 3,000 nucleotides, just upstream of NS1 and VP1/2 ORFs; highlighted by the two arrows. Note the high level of conservation between all three genomes toward the 3′ terminus of NS1 and the 5′ terminus of VP1/2 ORFs, presumably the result of functional constraint.</p

Conditional logistic regression of all viruses associated with gastroenteritis with P value<0.2 in the univariate analysis (Table 2, pooled samples from cases).

*<p>Viruses detected from 186 cases and 186 age-matched paired controls in which recognized bacterial pathogens were not detected.</p>†<p>OR, odds ratio.</p>‡<p>CI, 95% confidence interval.</p

Comparison of the open reading frames for HBoV2-W153, HBoV2-W208, HBoV3-W471, and HBoV st1.

*<p>Number of amino acids encoded for each protein.</p>†<p>Pairwise percent dissimilarity at both the nucleotide and amino acid (parentheses) levels.</p

Maximum likelihood dendrogram (bootstrapped, 1,000 replicates) of HBoV, HBoV2, and HBoV3 partial NS1 sequences.

<p>Maximum likelihood dendrogram (bootstrapped, 1,000 replicates) of HBoV, HBoV2, and HBoV3 partial NS1 sequences.</p