2 research outputs found
A new member of the cationic dinitrosyl iron complexes family incorporating N-ethylthiourea is effective against human HeLa and MCF-7 tumor cell lines
No full text<p>A new analog of the active site of mononuclear dinitrosyl [1Fe–2S] proteins, [C<sub>3</sub>N<sub>2</sub>H<sub>8</sub>SFe(NO)<sub>2</sub>Cl][Fe(NO)<sub>2</sub>(C<sub>3</sub>N<sub>2</sub>H<sub>8</sub>S)<sub>2</sub>]<sup>+</sup>Cl<sup>−</sup> (<b>I</b>), has been synthesized by reacting NO with an aqueous mixture of iron(II) sulfate and N-ethylthiourea in acidic medium. The structure and properties of the complex were studied by X-ray diffraction, IR, Mössbauer, and EPR spectroscopy, in addition to quantum chemical calculations. Complex <b>I</b> spontaneously generates NO in protic media. The cytotoxicity of <b>I</b> was investigated against human cervical carcinoma (HeLa), breast cancer (MCF7), and non-immortalized (FetMCS) cell lines. The cytotoxicity of <b>I</b> against HeLa is similar to that of anticancer agents currently used clinically (platinum complexes), but <b>I</b> is 10 times less toxic in normal cells. The cytotoxicity of MCF7 cells to <b>I</b> is low.</p
Multifunctional Compound Combining Conductivity and Single-Molecule Magnetism in the Same Temperature Range
No full textWe report the first
highly conducting single-molecule magnet, (BEDO)<sub>4</sub>[ReF<sub>6</sub>]·6H<sub>2</sub>O [<b>1</b>; BEDO = bisÂ(ethylenedioxo)Âtetrathiafulvalene],
whose conductivity and single-molecule magnetism coexist in the same
temperature range. The compound was synthesized by BEDO electrocrystallization
in the presence of (Ph<sub>4</sub>P)<sub>2</sub>[ReF<sub>6</sub>]·2H<sub>2</sub>O and characterized by crystallography and measurements of
the conductivity and alternating-current magnetic susceptibility
