MicroRNAs mir‐184 and let‐7 alter Drosophila metabolism and longevity

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140032/1/acel12673.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/140032/2/acel12673-sup-0002-FigS1-S8.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/140032/3/acel12673_am.pd

Mitochondrial thioredoxin reductase 2 is elevated in long‐lived primate as well as rodent species and extends fly mean lifespan

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137684/1/acel12596-sup-0001-SupInfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137684/2/acel12596.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137684/3/acel12596_am.pd

Do sensory experiences affect how we age?

Can fruit flies teach us something about the way our senses impact our own aging process? Dr. Christi Gendron believes so, and she uses humor to explain how recent research with Drosophila melanogaster, also known as the common fruit fly, is changing our understanding of the ways in which sensory systems impact the aging process. The processes identified are similar to those found in our own bodies and are the basis for developing therapies that promote healthy aging in humans.TEDxJacksonvillehttp://deepblue.lib.umich.edu/bitstream/2027.42/192165/2/TedTalk.mp4Description of TedTalk.mp4 : Published versio

Investigation of the role of ADAMTS-4 and ADAMTS-5 in cartilage aggrecan degradation

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Ring neurons in the Drosophila central complex act as a rheostat for sensory modulation of aging.

Sensory perception modulates aging, yet we know little about how. An understanding of the neuronal mechanisms through which animals orchestrate biological responses to relevant sensory inputs would provide insight into the control systems that may be important for modulating lifespan. Here, we provide new awareness into how the perception of dead conspecifics, or death perception, which elicits behavioral and physiological effects in many different species, affects lifespan in the fruit fly, Drosophila melanogaster. Previous work demonstrated that cohousing Drosophila with dead conspecifics decreases fat stores, reduces starvation resistance, and accelerates aging in a manner that requires both sight and the serotonin receptor 5-HT2A. In this manuscript, we demonstrate that a discrete, 5-HT2A-expressing neural population in the ellipsoid body (EB) of the Drosophila central complex, identified as R2/R4 neurons, acts as a rheostat and plays an important role in transducing sensory information about the presence of dead individuals to modulate lifespan. Expression of the insulin-responsive transcription factor foxo in R2/R4 neurons and insulin-like peptides dilp3 and dilp5, but not dilp2, are required, with the latter likely altered in median neurosecretory cells (MNCs) after R2/R4 neuronal activation. These data generate new insights into the neural underpinnings of how perceptive events may impact aging and physiology across taxa

S3 Data -

(A) The first column is the age of the animals in days, while each subsequent column contains the survivorship values calculated for the fly population indicated at the top. The genotypes of the flies used were R4d-GAL4 x w1118 or R4d-GAL4 x UAS-foxo-RNAi. (C) The numbers of GFP-positive cells counted per brain in R2/R4-GAL4 x UAS-GFP (control) or R2/R4-GAL4 x UAS-GFP; UAS-foxo-RNAi animals. (XLSX)</p