Additional file 1 of In-vitro susceptibility and ex-vivo evaluation of macrocyclic lactone endectocides sub-lethal concentrations against Plasmodium vivax oocyst development in Anopheles arabiensis

Additional file 1: Table S1. Preparation of ivermectin, doramectin, and moxidectin concentrations (1-1000ng/mL) in spiked cattle blood. Table S2. Preparation of ivermectin, doramectin, and moxidectin sublethal concentrations (LC25 and LC5) in spiked Plasmodium vivax infected blood. Annex I. Malaria Patient’s Information Sheet. Annex II. Study participant informed Consent

Assay test results by product type.

<p>*Generic products; SD =  Standard deviation; NA =  Not applicable.</p><p>Assay test results by product type.</p

Association between the test results and areas of collection, types of drug outlets, and countries of origin.

<p>Association between the test results and areas of collection, types of drug outlets, and countries of origin.</p

Evaluation criteria and ranking system for the occurrence of failure.

<p>Evaluation criteria and ranking system for the occurrence of failure.</p

Pharmacopoeial quality test results by product.

<p>- Not performed.</p><p>Pharmacopoeial quality test results by product.</p

Evaluation criteria and ranking system for the detection of a cause of failure.

<p>Evaluation criteria and ranking system for the detection of a cause of failure.</p

Evaluation criteria and ranking system for the severity of effects.

<p>Evaluation criteria and ranking system for the severity of effects.</p

Comparative <i>in-vitro</i> release profile studies of different products of tinidazole (TNZ) tablets.

<p>All data points presented are mean values of triplicate experiments (n = 3) and error bars indicate standard deviations. Percent drug release should be between 70 and 130% within 120 min.</p

Linear desirability functions: (a) assay (%label claim), (b) dissolution (%drug release), (c) dosage uniformity (%RSD) and (d) identity (compliance to specification).

<p>Linear desirability functions: (a) assay (%label claim), (b) dissolution (%drug release), (c) dosage uniformity (%RSD) and (d) identity (compliance to specification).</p

Distribution of D-values among the investigated products.

<p>Distribution of D-values among the investigated products.</p