Plasma protein carbonyl and thiol stress before and after laparoscopic gastric banding in morbidly obese patients

Background: The aim of this study is to examine the relationship between oxidative plasma protein and thiol stress and weight loss after laparoscopic adjustable gastric banding (LAGB)

Superoxide Dismutase and Glutathione in Otitis Media with Effusion: Relation with Hearing Loss

Objective: To investigate the role of antioxidant defense in otitis media with effusion (OME) and the relation of hearing loss with antioxidant defenses by measuring the concentration of Superoxide Dismutase (SOD) and glutathione (GSH) of both middle ear effusions (MEE) and erythrocytes

Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis

AIM: Oxygen free radical mediated tissue damage is well established in pathogenesis of acute pancreatitis (AP). Whether nitric oxide (NO) plays a deleterious or a protective role is unknown. In alcohol-induced AP, we studied NO, lipooxidative damage and glutathione in pancreas, lung and circulation

Increased Maternal Serum and Cord Blood Fibronectin Concentrations in Preeclampsia are Associated with Higher Placental Hyaluronic Acid and Hydroxyproline Content

Background. Total or cellular fibronectin (FN) determinations have been used to differentiate between normal and preeclamptic pregnants. The purpose of this study was to examine the relationship between maternal serum FN levels and the extracellular matrix molecule contents of placental tissue, such as FN, hyaluronic acid (HA) and hydroxyproline (HP) levels. Material and Methods. We obtained maternal blood samples and placental tissue samples from healthy (n = 17, controls) and preeclamptic pregnants (n = 29). We also obtained cord blood samples for FN and HA determination from the same patients. FN and HA concentrations in the placenta and maternal and cord blood were measured by and enzyme-linked immunosorbent assay and HP contents in the placenta were measured by a colorimetric assay. Results. FN levels in maternal serum, cord blood, and placenta were significantly higher in preeclamptics than in controls (p < 0.001, p < 0.001 and p < 0.05, respectively). HA concentrations in the cord blood and placenta were found to be elevated in preeclamptics (p < 0.05 and p < 0.01). Preeclamptics had significantly higher placental HP levels than controls (p < 0.001). Similar statistically significant results were obtained when the pregnant subjects classified as nulliparous and multiparous. There was no difference in ECM molecule levels between nulliporous and multiparous women in preeclamptic pregnant group. In regression analysis maternal serum FN levels were correlated with placental HA and HP levels (p < 0.01 and p < 0.01). There was a positive correlation between cord blood FN and both placental HP (p < 001) and HA levels (p < 0.01). FN levels in maternal serum, cord blood, and placenta were also negative correlated with fetal birth weight (p < 0.01, p < 0.05 and p < 0.05, respectively). Conclusion. FN in maternal serum, cord blood, and placenta is increased with elevated placental HA and HP levels, probably reflecting placental basement membrane alterations during preeclampsia.</

The effect of fluoxetine on ischemia-reperfusion after aortic surgery in a rat model

Background: Aortic ischemia-reperfusion (IR) is an important factor in the development of postoperative acute lung injury after abdominal aortic surgery. The aim of the present study was to examine the effect of fluoxetine (Flx), a selective serotonin reuptake inhibitor widely used as a preoperative anxiolytic, on lung injury induced by abdominal aortic IR in rats