8 research outputs found

    A new asymmetric synthesis of 2,6-cis-disubstituted-4-methylenpiperidines. Total synthesis of (+)-alkaloid 241D and (+)-isosolenopsin A

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    A highly diastereoselective synthesis of 2,6-cis-disubstituted-4-methylenepiperidines based on a Mannich type intramolecular cyclization of an allylsilane on an iminium ion is described. The synthetic potential of this methodology is demonstrated by the enantioselective synthesis of two natural piperidine alkaloids: (+)-alkaloid 241D and (+)-isosolenopsin

    Stereoselective Synthesis of Amido and Phenyl Azabicyclic Derivatives via a Tandem Aza Prins-Ritter/Friedel–Crafts Type Reaction of Endocyclic N

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    Cyclizations of N

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    Vinyl Epoxides in Organic Synthesis

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