Electrical brain responses reveal sequential constraints on planning during music performance

Funding: National Science Foundation Graduate Research Fellowship to B.M. Canada Research Chairs grant and Natural Sciences and Engineering Research Council of Canada grant 298173 to C.P.Peer reviewe

Auditory N1 reveals planning and monitoring processes during music performance

The current study investigated the relationship between planning processes and feedback monitoring during music performance, a complex task in which performers prepare upcoming events while monitoring their sensory outcomes. Theories of action planning in auditory‐motor production tasks propose that the planning of future events co‐occurs with the perception of auditory feedback. This study investigated the neural correlates of planning and feedback monitoring by manipulating the contents of auditory feedback during music performance. Pianists memorized and performed melodies at a cued tempo in a synchronization‐continuation task while the EEG was recorded. During performance, auditory feedback associated with single melody tones was occasionally substituted with tones corresponding to future (next), present (current), or past (previous) melody tones. Only future‐oriented altered feedback disrupted behavior: Future‐oriented feedback caused pianists to slow down on the subsequent tone more than past‐oriented feedback, and amplitudes of the auditory N1 potential elicited by the tone immediately following the altered feedback were larger for future‐oriented than for past‐oriented or noncontextual (unrelated) altered feedback; larger N1 amplitudes were associated with greater slowing following altered feedback in the future condition only. Feedback‐related negativities were elicited in all altered feedback conditions. In sum, behavioral and neural evidence suggests that future‐oriented feedback disrupts performance more than past‐oriented feedback, consistent with planning theories that posit similarity‐based interference between feedback and planning contents. Neural sensory processing of auditory feedback, reflected in the N1 ERP, may serve as a marker for temporal disruption caused by altered auditory feedback in auditory‐motor production tasks.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/136038/1/psyp12781_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/136038/2/psyp12781.pd

Associations between developmental changes in error‐related brain activity and executive functions in early childhood

Behavioral evidence indicates that skills associated with children’s cognitive control (e.g., response inhibition and attentional control) undergo rapid development during early childhood. A particularly important time is the transition to elementary school. Yet, at present, relatively little is known about developmental changes in the brain processes linked to cognitive control during this period, including those associated with error monitoring, including the error‐related negativity (ERN) and the error positivity (Pe). Moreover, understanding how ERP correlates of cognitive control relate to behavioral measures of these skills over time is also limited. In the present study, repeated assessments of 4‐ to 6‐year‐old children’s (N = 49, mean age = 5 years 10 months) performance on a go/no‐go task were collected to examine developmental changes in error processing and response inhibition across 6 months. Data revealed the presence of both the ERN and Pe at each time point, but also showed individual differences in the test‐retest associations for each component. Behavioral changes in response inhibition on the go/no‐go task and a standardized measure of attentional control were associated with changes in electrophysiological measures of error processing. Additional analyses comparing children of the same age who had completed the go/no‐go task once to those who participated longitudinally revealed that, with repeated assessments, children exhibited behavioral changes in performance that could be attributed to both development and to the effects of practice, such as strategic accommodation.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142529/1/psyp13040.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142529/2/psyp13040_am.pd

Perceptual properties of feedback stimuli influence the feedback‐related negativity in the flanker gambling task

A negative deflection in the event‐related potential is enhanced following error‐ and loss‐related feedback in decision‐making and simple gambling tasks. Researchers have assumed that the perceptual properties of the feedback stimuli are unimportant in explaining these effects. This assumption was tested in the present study through a flanker gambling task, in which the perceptual properties of the feedback were manipulated. Consistent with previous studies, loss elicited a larger feedback‐related negativity ( FRN ) than gain feedback. However, this FRN reward effect was modulated by the perceptual properties of the feedback stimuli. When gain and loss feedback were perceptually similar to each other, the enhancement of the FRN following the loss feedback was smaller compared to when the gain and loss feedback were different from each other. In addition, incongruent feedback elicited a larger FRN than congruent feedback; this FRN congruency effect was larger following gain than loss feedback. These results suggested that perceptual properties of the feedback stimuli play a role in the elicitation of the FRN .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108013/1/psyp12216.pd

Trial-by-Trial Adjustments of Cognitive Control Following Errors and Response Conflict are Altered in Pediatric Obsessive Compulsive Disorder

Background: Impairments of cognitive control have been theorized to drive the repetitive thoughts and behaviors of obsessive compulsive disorder (OCD) from early in the course of illness. However, it remains unclear whether altered trial-by-trial adjustments of cognitive control characterize young patients. To test this hypothesis, we determined whether trial-by-trial adjustments of cognitive control are altered in children with OCD, relative to healthy controls. Methods: Forty-eight patients with pediatric OCD and 48 healthy youth performed the Multi-Source Interference Task. Two types of trial-by-trial adjustments of cognitive control were examined: post-error slowing (i.e., slower responses after errors than after correct trials) and post-conflict adaptation (i.e., faster responses in high-conflict incongruent trials that are preceded by other high-conflict incongruent trials, relative to low-conflict congruent trials). Results: While healthy youth exhibited both post-error slowing and post-conflict adaptation, patients with pediatric OCD failed to exhibit either of these effects. Further analyses revealed that patients with low symptom severity showed a reversal of the post-conflict adaptation effect, whereas patients with high symptom severity did not show any post-conflict adaptation. Conclusion: Two types of trial-by-trial adjustments of cognitive control are altered in pediatric OCD. These abnormalities may serve as early markers of the illness

Brain Activity Elicited by Positive and Negative Feedback in Preschool-Aged Children

To investigate the processing of positive vs. negative feedback in children aged 4–5 years, we devised a prize-guessing game that is analogous to gambling tasks used to measure feedback-related brain responses in adult studies. Unlike adult studies, the feedback-related negativity (FRN) elicited by positive feedback was as large as that elicited by negative feedback, suggesting that the neural system underlying the FRN may not process feedback valence in early childhood. In addition, positive feedback, compared with negative feedback, evoked a larger P1 over the occipital scalp area and a larger positive slow wave (PSW) over the right central-parietal scalp area. We believe that the PSW is related to emotional arousal and the intensive focus on positive feedback that is present in the preschool and early school years has adaptive significance for both cognitive and emotional development during this period

Molecular Orbital Models of Benzene, Biphenyl and the Oligophenylenes

A two state (2-MO) model for the low-lying long axis-polarised excitations of poly(p-phenylene) oligomers and polymers is developed. First we derive such a model from the underlying Pariser-Parr-Pople (P-P-P) model of pi-conjugated systems. The two states retained per unit cell are the Wannier functions associated with the valence and conduction bands. By a comparison of the predictions of this model to a four state model (which includes the non-bonding states) and a full P-P-P model calculation on benzene and biphenyl, it is shown quantitatively how the 2-MO model fails to predict the correct excitation energies. The 2-MO model is then solved for oligophenylenes of up to 15 repeat units using the density matrix renormalisation group (DMRG) method. It is shown that the predicted lowest lying, dipole allowed excitation is ca. 1 eV higher than the experimental result. The failure of the 2-MO model is a consequence of the fact that the original HOMO and LUMO single particle basis does not provide an adequate representation for the many body processes of the electronic system.Comment: LaTeX, 12 pages, 3 eps figures included using epsf. To appear in Chemical Physics, 199

Error‐related brain activity in adolescents with obsessive‐compulsive disorder and major depressive disorder

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/145307/1/da22767_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/145307/2/da22767.pd

Chronic medication does not affect hyperactive error responses in obsessive-compulsive disorder

Patients with obsessive-compulsive disorder (OCD) show an increased error-related negativity (ERN), yet previous studies have not controlled for medication use, which may be important given evidence linking performance monitoring to neurotransmitter systems targeted by treatment, such as serotonin. In an examination of 19 unmedicated OCD patients, 19 medicated OCD patients, 19 medicated patient controls without OCD, and 21 unmedicated healthy controls, we found greater ERNs in OCD patients than in controls, irrespective of medication use. Severity of generalized anxiety and depression was associated with ERN amplitude in controls but not patients. These data confirm previous findings of an exaggerated error response in OCD, further showing that it cannot be attributed to medication. The absence in patients of a relationship between ERN amplitude and anxiety/depression, as was found in controls, suggests that elevated error signals in OCD may be disorder-specific.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79361/1/j.1469-8986.2010.00988.x.pd