An update on the potential for male contraception : emerging options

The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women. Current options available to men include withdrawal, condoms, and vasectomy. Methods in development fall into two categories: hormonal and nonhormonal. This review will provide an overview of the testosterone combinations and immunocontraception of hormonal targets. Nonhormonal immunocontraception of sperm proteins will also be examined, together with the use of agents to disrupt other sperm-associated targets and pathways. The categories focused on include epididymal proteins, testicular kinases, epigenetic reader proteins, opioids, lonidamine derivatives, retinoic acid, microRNAs associated with spermatogenesis, and plant extracts. Considering these developments, the number of options available to men is likely to increase in the near future

NIOSOMES VERSUS PRONIOSOMES AS PROMISING DRUG DELIVERY SYSTEMS IN TREATMENT OF DIABETES MELLITUS

Diabetes Mellitus (DM) has emerged as an epidemic that has affected millions of people globally in the last few decades. Conventional antidiabetic dosage forms have a lot of problems that necessitate searching for novel drug delivery systems to overcome these drawbacks. Niosomes and proniosomes have been used to carry a wide variety of antidiabetic drugs achieving controlled and sustained release, which improves patient compliance. This review article describes the fundamental aspects of niosomes and proniosomes, including their structural components, methods of preparation, advantages and drawbacks, characterization, factors affecting niosomes formation along with their application in the treatment of diabetes. It also highlights the participation of other drug delivery systems in the treatment of diabetes done, mainly in the last decade

Resistive switching in FTO/CuO-Cu2O/Au memory devices

Memristors are considered to be next-generation non-volatile memory devices owing to their fast switching and low power consumption. Metal oxide memristors have been extensively investigated and reported to be promising devices, although they still suffer from poor stability and laborious fabrication process. Herein, we report a stable and power-efficient memristor with novel heterogenous electrodes structure and facile fabrication based on CuO-Cu2O complex thin films. The proposed structure of the memristor contains an active complex layer of cupric oxide (CuO) and cuprous oxide (Cu2O) sandwiched between fluorine-doped tin oxide (FTO) and gold (Au) electrodes. The fabricated memristors demonstrate bipolar resistive switching (RS) behavior with a low working voltage (~1 V), efficient power consumption, and high endurance over 100 switching cycles. We suggest the RS mechanism of the proposed device is related to the formation and rupture of conducting filaments inside the memristor. Moreover, we analyze the conduction mechanism and electron transport in the active layer of the device during the RS process. Such a facile fabricated device has a promising potential for future memristive applications

The effect of the rheocast process on the microstructure and mechanical properties of Al-5.7Si-2Cu-0.3Mg alloy

This study shows the results of an experimental investigation of semisolid rheocasting of Al-5.7Si-2Cu-0.3Mg alloy using a cooling slope (CS) casting technique. However, the challenge is to determine process parameters of the CS process to get a desirable microstructure in the semisolid feedstock material. cooling slope technique was employed to create feedstock material for thixoforming under an argon gas atmosphere, where on an inclined plate that was fixed at a 60° slope angle, molten alloy is poured at different temperatures of 640°C, 650°C and 660°C at lengths 300, 400 and 500 mm. Examination the microstructure with optical microscope observed that the microstructure of conventionally cast alloy presented coarse and dendritic primary α-Al phase, whereas rheocast alloy included fine and nondendritic primary α-Al phase with homogeneous distribution of eutectic phase. The best CS processing condition has been identified for optimum pouring temperature of 650°C and the slope length of 400 mm as average globular grain size of around 31.67 ± 3 μm and a shape factor of about 0.66 ± 0.09 were obtained. The mechanical properties of conventional cast alloy were enhanced by the CS casting process. The ultimate tensile strength, the yield strength and elongation of the rheocast alloy were increased by 10%, 12% and 22% respectively compared to the conventional cast alloy. due to a reduction in shrinkage and porosity of the microstructure of the CS alloy

The health-related quality of life in normal and obese children

AbstractBackgroundOverweight and obesity have a major impact on the quality of life (QOL) in different patterns and magnitudes.ObjectiveTo assess the effect of obesity on the quality of life in children.Patients and methodsThe study was carried out on 111 children aged from six to twelve years in National Nutrition Institute. They were divided according to age into two groups; group I for children ⩽8years (n=42) and group II for children >8years (n=69). Only obese children of nutritional cause of obesity were included in this study. The data were collected by different tools, questionnaire and clinical Assessment.ResultsResults showed that; in group I (⩽8years); 20 children were of normalweight (47.6%) and 22 were obese (52.4%), while in group II (>8years old); 29 of them were of normal weight (42.0%) and 40 were obese (58.0%). The Mean±SD of body mass index (BMI), height and weight in normal and obese children were significantly different. The socioeconomic class relation between normal and obese children was significantly different. The total quality of life score was ⩾75 (very good QoL) in 95.0% and 82.8% of normal weight children, while the percentage was only 4.5% and 5.0% in obese children (⩽8years and >8years, respectively). On the other hand, the total score was ⩽25% (bad QoL Life) in only 0.0% and 6.9% of normal weight children, while it was 31.8% and 17.5% in obese children (⩽8years and >8years, respectively).There was a negative correlation relationship between total quality of life scores and BMI, waist circumference, weight and a positive correlation relationship between quality of life scores and father’s and mother’s education and father’s occupation.ConclusionObesity in children had a negative impact on their quality of life

Market Integration Shape Organic Farmers’ Organisation

Increasing consumption of organic products in globalised food chains will require the involvement of thousands more smallholder farmers in many regions of the world. A study of Egypt, China and Uganda identified the three key factors of property rights regimes, cultural differences and social organisation as determents of the supply chain organization and farmers’ degree of direct integration in the export markets. Patterns are emerging where smallholder farmers are being socially and economically linked to larger farmers who may do some processing before the raw materials are handed over to the contracting company. Where transactions costs are high, local communities may develop and contract out the land directly to exporting companies who farm using employees. Four organisational patterns are identified which each leads to different types of livelihood benefits for the producers; preliminary results indicate that income and a reliable market access is the dominant benefits

Effect of equal channel angular pressing processing routes on corrosion resistance and hardness of heat treated A356 alloy

Equal channel angular pressing (ECAP) via routes A and Bc was used to process heat treated A356 alloy. The samples produced a range of microstructures in order to investigate the effect of straining on its corrosion behavior in 3.5 wt. % NaCl solution and hardness. The ECAP was conducted at room temperature in a mold with channel angle of 120°. The results show that brittle coarse silicon particles were effectively fragmented into smaller size in the Al-rich matrix after the processing. The hardness and corrosion resistance test showed improvement after T5 and T6 heat treatment, preferably to T6 due to wholly changed in silicon particles morphology than T5. The hardness increased with ECAP processing from 60.66 Hv to 1133.47, 124.91 Hv after three passes route Bc and four passes route A, respectively. The evaluation of corrosion resistance of the alloy showed improvement from 0.0424 to 0.00173, 0.00149 mmy-1 after three passes route Bc and four passes route A, respectively. In this research, both strength and corrosion resistance are improved by ECAP processing of A356 alloy using both routes

Comparison of the physical characteristics of monodisperse non-ionic surfactant vesicles (NISV) prepared using different manufacturing methods

Non-ionic surfactant vesicles (NISV) are synthetic membrane vesicles formed by self-assembly of a non-ionic surfactant, often in a mixture with cholesterol and a charged chemical species. Different methods can be used to manufacture NISV, with the majority of these requiring bulk mixing of two phases. This mixing process is time-consuming and leads to the preparation of large and highly dispersed vesicles, which affects the consistency of the final product and could hinder subsequent regulatory approval. In this study, we have compared the physical characteristics of NISV prepared using two conventional methods (thin-film hydration method and heating method) with a recently introduced microfluidic method. The resulting particles from these methods were assessed for their physical characteristics and in vitro cytotoxicity. Through microfluidics, nano-sized NISV were prepared in seconds, through rapid and controlled mixing of two miscible phases (lipids dissolved in alcohol and an aqueous medium) in a microchannel, without the need of a size reduction step, as required for the conventional methods. Stability studies over two months showed the particles were stable regardless of the method of preparation and there were no differences in terms of EC50 on A375 and A2780 cell lines. However, this work demonstrates the flexibility and ease of applying lab-on-chip microfluidics for the preparation of NISV that could be used to significantly improve formulation research and development, by enabling the rapid manufacture of a consistent end-product, under controlled conditions

A biochemical, theoretical and immunohistochemical study comparing the therapeutic efficacy of curcumin and taurine on T-2 toxin induced hepatotoxicity in rats

Introduction: Foodborne trichothecene T-2 Toxin, is a highly toxic metabolite produced by Fusarium species contaminating animal and human food, causing multiple organ failure and health hazards. T-2 toxins induce hepatotoxicity via oxidative stress causing hepatocytes cytotoxicity and genotoxicity. In this study, curcumin and taurine were investigated and compared as antioxidants against T-2-provoked hepatotoxicity.Methods: Wistar rats were administrated T-2 toxin sublethal oral dose (0.1 mg/kg) for 2 months, followed by curcumin (80 mg/kg) and taurine (50 mg/kg) for 3 weeks. Biochemical assessment of liver enzymes, lipid profiles, thiobarbituric acid reactive substances (TBARs), AFU, TNF-α, total glutathione, molecular docking, histological and immunohistochemical markers for anti-transforming growth factor-β1 (TGFβ1), double-strand DNA damage (H2AX), regeneration (KI67) and apoptosis (Active caspase3) were done.Results and Discussion: Compared to T-2 toxin, curcumin and taurine treatment significantly ameliorated hepatoxicity as; hemoglobin, hematocrit and glutathione, hepatic glycogen, and KI-67 immune-reactive hepatocytes were significantly increased. Although, liver enzymes, inflammation, fibrosis, TGFβ1 immunoexpressing and H2AX and active caspase 3 positive hepatocytes were significantly decreased. Noteworthy, curcumin’s therapeutic effect was superior to taurine by histomorphometry parameters. Furthermore, molecular docking of the structural influence of curcumin and taurine on the DNA sequence showed curcumin’s higher binding affinity than taurine.Conclusion: Both curcumin and taurine ameliorated T-2 induced hepatotoxicity as strong antioxidative agents with more effectiveness for curcumin

The Ocular Conjunctiva as a Mucosal Immunization Route: A Profile of the Immune Response to the Model Antigen Tetanus Toxoid

Background: In a quest for a needle-free vaccine administration strategy, we evaluated the ocular conjunctiva as an alternative mucosal immunization route by profiling and comparing the local and systemic immune responses to the subcutaneous or conjunctival administration of tetanus toxoid (TTd), a model antigen. Materials and methods: BALB/c and C57BL/6 mice were immunized either subcutaneously with TTd alone or via the conjunctiva with TTd alone, TTd mixed with 2% glycerol or TTd with merthiolate-inactivated whole-cell B. pertussis (wBP) as adjuvants. Mice were immunized on days 0, 7 and 14 via both routes, and an evaluation of the local and systemic immune responses was performed two weeks after the last immunization. Four weeks after the last immunization, the mice were challenged with a lethal dose (2 x LD50) of tetanus toxin. Results: The conjunctival application of TTd in BALB/c mice induced TTd-specific secretory IgA production and skewed the TTd-specific immune response toward a Th1/Th17 profile, as determined by the stimulation of IFN gamma and IL-17A secretion and/or the concurrent pronounced reduction of IL-4 secretion, irrespective of the adjuvant. In conjunctivaly immunized C57BL/6 mice, only TTd administered with wBP promoted the establishment of a mixed Th1/Th17 TTd-specific immune response, whereas TTd alone or TTd in conjunction with glycerol initiated a dominant Th1 response against TTd. Immunization via the conjunctiva with TTd plus wBP adjuvant resulted in a 33% survival rate of challenged mice compared to a 0% survival rate in non-immunized animals (p lt 0.05). Conclusion: Conjunctival immunization with TTd alone or with various adjuvants induced TTd-specific local and systemic immune responses, predominantly of the Th1 type. The strongest immune responses developed in mice that received TTd together with wBP, which implies that this alternative route might tailor the immune response to fight intracellular bacteria or viruses more effectively