Spatial Relationships of Urban Land Use, Soils and Heavy Metal Concentrations in Lagos Mainland Area

Soils are the basic and most important resources of any people. Differences in soil\u2019s physical and chemical properties are related to the spatial distribution of land uses. Most of these human activities generate toxic substances that are transported considerable distances away from source and become accumulated in soils, sediment, water bodies and fisheries. Urban soils are largely affected by impact of urbanization whose consumptive pattern is related to the social and economic aspect of the society. The study deployed contaminant factor (CF) and geo-accumulation index (Igeo) to examine the differences in the urban soils of Lagos Mainland Area due to human activities. The topsoils of the predominant human activities identified in the area were sampled and analyzed to find out the differences in the soils due to the concentration of heavy metals among six land use types. The coefficient of variation and standard deviation techniques were deployed to study the degree of variation and compare the mean values of soil physical and chemical properties of twelve representative topsoils collected from six locations. All metals analyzed showed significant (p<0.05) variation in the concentration of heavy metals, CF and Igeo among land uses. Spatial distribution of heavy metals indicates areas of potential risks of harmful heavy metals in the urban environment which enhances action plan for remediation and protection of the urban environment

Modified analytical approach for PV-DGs integration into radial distribution network considering loss sensitivity and voltage stability

Abstract: Achieving the goals of distribution systems operation often involves taking vital decisions with adequate consideration for several but often contradictory technical and economic criteria. Hence, this paper presents a modified analytical approach for optimal location and sizing of solar PV-based DG units into radial distribution network (RDN) considering strategic combination of important power system planning criteria. The considered criteria are total planning cost, active power loss and voltage stability, under credible distribution network operation constraints. The optimal DG placement approach is derived from the modification of the analytical approach for DG placement using line-loss sensitivity factor and the multiobjective constriction factor-based particle swarm optimization is adopted for optimal sizing. The effectiveness of the proposed procedure is tested on the IEEE 33-bus system modeled using Matlab considering three scenarios. The results are compared with existing reports presented in the literature and the results obtained from the proposed approach shows credible improvement in the RDN steady-state operation performance for line-loss reduction, voltage profile improvement and voltage stability improvement

Treatment of fast breathing in neonates and young infants with oral amoxicillin compared with penicillin-gentamicin combination: study protocol for a randomized, open-label equivalence trial

Background: The World Health Organization recommends hospitalization and injectable antibiotic treatment for young infants (0–59 days old), who present with signs of possible serious bacterial infection. Fast breathing alone is not associated with a high mortality risk for young infants and has been treated with oral antibiotics in some settings. This trial was designed to examine the safety and efficacy of oral amoxicillin for young infants with fast breathing compared with that of an injectable penicillin–gentamicin combination. The study is currently being conducted in the Democratic Republic of Congo, Kenya and Nigeria Methods/Design: This is a randomized, open-label equivalence trial. All births in the community are visited at home by trained community health workers to identify sick infants who are then referred to a trial study nurse for assessment. The primary outcome is treatment failure by day 8 after enrollment, defined as clinical deterioration, development of a serious adverse event including death, persistence of fast breathing by day 4 or recurrence up to day 8. Secondary outcomes include adherence to study therapy, relapse, death between days 9 and 15 and adverse effects associated with the study drugs. Study outcomes are assessed on days 4, 8, 11 and 15 after randomization by an independent outcome assessor who is blinded to the treatment being given. Discussion: The results of this study will help inform the development of policies for the treatment of fast breathing among neonates and young infants in resource-limited settings

Simplified Regimens for Management of Neonates and Young Infants With Severe Infection When Hospital Admission Is Not Possible

Background: In resource-limited settings, most young infants with signs of severe infection do not receive the recommended inpatient treatment with intravenous broad spectrum antibiotics for 10 days or more because such treatment is not accessible, acceptable or affordable to families. This trial was initiated in the Democratic Republic of Congo, Kenya and Nigeria to assess the safety and efficacy of simplified treatment regimens for the young infants with signs of severe infection who cannot receive hospital care. Methods: This is a randomized, open-label equivalence trial in which 3600 young infants with signs of clinical severe infection will be enrolled. The primary outcome is treatment failure in 7 days after enrollment, which includes death or worsening of the clinical condition on any day, or no improvement in the clinical condition by day 4 of treatment. Secondary outcomes include compliance with study therapy, adverse effects due to the study drugs and relapse or death during the week after completion of treatment. Discussion: The results of this study, along with ongoing studies in Pakistan and Bangladesh, will inform the development of global policy for treatment of severe neonatal infections in resource-limited settings

Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux

Primary vesicoureteral reflux (PVUR) is the most common malformation of the kidney and urinary tract and reflux nephropathy is a major cause of chronic kidney disease in children. Recently, we reported mutations in tenascin XB (TNXB) as a cause of PVUR with joint hypermobility

Gaining the PROMIS perspective from children with nephrotic syndrome: a Midwest pediatric nephrology consortium study

Background and objectives Nephrotic syndrome (NS) represents a common disease in pediatric nephrology typified by a relapsing and remitting course and characterized by the presence of edema that can significantly affect the health-related quality of life in children and adolescents. The PROMIS pediatric measures were constructed to be publically available, efficient, precise, and valid across a variety of diseases to assess patient reports of symptoms and quality of life. This study was designed to evaluate the ability of children and adolescents with NS to complete the PROMIS assessment via computer and to initiate validity assessments of the short forms and full item banks in pediatric NS. Successful measurement of patient reported outcomes will contribute to our understanding of the impact of NS on children and adolescents. Design This cross-sectional study included 151 children and adolescents 8-17 years old with NS from 16 participating institutions in North America. The children completed the PROMIS pediatric depression, anxiety, social-peer relationships, pain interference, fatigue, mobility and upper extremity functioning measures using a web-based interface. Responses were compared between patients experiencing active NS (n = 53) defined by the presence of edema and patients with inactive NS (n = 96) defined by the absence of edema. Results All 151 children and adolescents were successfully able to complete the PROMIS assessment via computer. As hypothesized, the children and adolescents with active NS were significantly different on 4 self-reported measures (anxiety, pain interference, fatigue, and mobility). Depression, peer relationships, and upper extremity functioning were not different between children with active vs. inactive NS. Multivariate analysis showed that the PROMIS instruments remained sensitive to NS disease activity after adjusting for demographic characteristics. Conclusions Children and adolescents with NS were able to successfully complete the PROMIS instrument using a web-based interface. The computer based pediatric PROMIS measurement effectively discriminated between children and adolescents with active and inactive NS. The domain scores found in this study are consistent with previous reports investigating the health-related quality of life in children and adolescents with NS. This study establishes known-group validity and feasibility for PROMIS pediatric measures in children and adolescents with NS

The impact of disease duration on quality of life in children with nephrotic syndrome: a Midwest Pediatric Nephrology Consortium study

The Patient Reported Outcomes Measurement Information System (PROMIS) II is a prospective study that evaluates patient reported outcomes in pediatric chronic diseases as a measure of health-related quality of life (HRQOL). We have evaluated the influence of disease duration on HRQOL and, for the first time, compared the findings of the PROMIS measures to those of the PedsQL™ 4.0 Generic Scales (PedsQL) from the PROMIS II nephrotic syndrome (NS) longitudinal cohort

Gaining the Patient Reported Outcomes Measurement Information System (PROMIS) perspective in chronic kidney disease: a Midwest Pediatric Nephrology Consortium study

Chronic kidney disease is a persistent chronic health condition commonly seen in pediatric nephrology programs. Our study aims to evaluate the sensitivity of the Patient Reported Outcomes Measurement Information System (PROMIS) pediatric instrument to indicators of disease severity and activity in pediatric chronic kidney disease

Spatial Relationships of Urban Land Use, Soils and Heavy Metal Concentrations in Lagos Mainland Area

Soils are the basic and most important resources of any people. Differences in soil’s physical and chemical properties are related to the spatial distribution of land uses. Most of these human activities generate toxic substances that are transported considerable distances away from source and become accumulated in soils, sediment, water bodies and fisheries. Urban soils are largely affected by impact of urbanization whose consumptive pattern is related to the social and economic aspect of the society. The study deployed contaminant factor (CF) and geo-accumulation index (Igeo) to examine the differences in the urban soils of Lagos Mainland Area due to human activities. The topsoils of the predominant human activities identified in the area were sampled and analyzed to find out the differences in the soils due to the concentration of heavy metals among six land use types. The coefficient of variation and standard deviation techniques were deployed to study the degree of variation and compare the mean values of soil physical and chemical properties of twelve representative topsoils collected from six locations. All metals analyzed showed significant (p<0.05) variation in the concentration of heavy metals, CF and Igeo among land uses. Spatial distribution of heavy metals indicates areas of potential risks of harmful heavy metals in the urban environment which enhances action plan for remediation and protection of the urban environment