2 research outputs found
Leveraging Zn(II) Catalyst: Synthesis of Amidoquinolines via (3 + 3) Heteroannulation of Aromatic Amines and Ynamides
Herein,
we present a ZnÂ(II)-catalyzed (3 + 3) heteroannulation
reaction between aromatic amines and 1,3-diynamides for the synthesis
of amidoquinolines. A large number of aromatic amines are well tolerated,
furnishing quinoline derivatives in up to excellent yield. Notably,
various reactive functional groups have survived under the optimal
reaction conditions, highlighting the mildness of the developed protocol.
In addition, amines derived from bioactive molecules show modest reactivity
Leveraging Zn(II) Catalyst: Synthesis of Amidoquinolines via (3 + 3) Heteroannulation of Aromatic Amines and Ynamides
Herein,
we present a ZnÂ(II)-catalyzed (3 + 3) heteroannulation
reaction between aromatic amines and 1,3-diynamides for the synthesis
of amidoquinolines. A large number of aromatic amines are well tolerated,
furnishing quinoline derivatives in up to excellent yield. Notably,
various reactive functional groups have survived under the optimal
reaction conditions, highlighting the mildness of the developed protocol.
In addition, amines derived from bioactive molecules show modest reactivity