The Outcome of Patients with Melanoma Is Not Associated with the Time Point of Lymphatic Mapping with Respect to Excisional Biopsy of the Primary Tumor

Background: Sentinel lymph node biopsy (SLNB) has become the standard care for melanoma and is an important diagnostic procedure. It has been doubted whether lymphoscintigraphy detects the correct sentinel lymph node (SLN) when excision of the tumor and SLNB are not performed at the same time. This would imply that this sequential approach may have an increased risk of undetected micrometastases resulting in a worse outcome. Objective: The purpose of the present study was to compare the outcome of melanoma patients having received excision of the tumor and SLNB either at the same time or consecutively. Methods: A total of 854 patients with cutaneous melanoma were enrolled in this retrospective study between September 1996 and November 2007. Disease-free (DFS) and overall survivals (OS) were estimated using the Kaplan-Meier product limit method and were analyzed by the log rank test. Results: No statistically significant difference was found regarding DFS, progression rates and OS in patients with primary tumor excision and SLNB at the same time compared with patients with excisional biopsy of primary tumor and SLNB at different times. Conclusion: These data suggest that excisional biopsy of the primary tumor does not prevent the correct SLN mapping in melanoma patients. Copyright (C) 2010 S. Karger AG, Base

Bestimmung der Emittanz eines hochenergetischen Elektronenstrahls durch Online-Auswertung von Strahlprofilmessungen

Das Ziel dieser Arbeit ist es, die Voraussetzungen für den durch einen Rechner gesteuerten Betrieb des externen Elektronenstrahls am Deutschen Elektronen-Synchrotron DESY zu schaffen

Heart rate variability, breathing and body movements in normoxic fetal lambs.

Peer Reviewe

John Cage: Etudes Boreales

Enormous technical requirements make John Cage's "Etudes Boreales" a highly virtuosic work, which requires an extreme sensitivity of feeling for the coordination of fingers, instrument, and intellect. On this CD it is presented in versions: for piano solo and later for cello solo with piano solo. As in the sister works, "Etudes Australes" and "Freeman Etudes", Cage based the "Etudes Boreales" on a star chart. He used the chart of the northern sky that the Czech astronomer Antonín Bevá? made in 1962. The time length piece 26'1.1499" – Friedrich Gauwerky chooses the first 640.3 seconds for this recording, thus giving the piece the titel 10'40.3" – documents the composer’s retreat from an intentional determination of the sounds. And also the "Harmonies" welcome the creative possibilities of whatever happens next.Etudes Boreales for a Percussionist Using a PianoHarmonies XIII, XXII, XXIV, XXVII for Violoncello and Piano10'40.3" for a String Player, as part of: 26’1.1499" for a String PlayerEtudes Boreales for Cello Solo and Piano Solo

Zur näheren Charakterisierung von Trypsininhibitoren bei dem Polychaeten Sabellastarte indica (Savigny). Zweite Mitteilung

Peer Reviewe

Über neue Proteaseinhibitoren mit breiter Wirkungsspezifität bei dem Polychaeten Sabellastarte indica (Savingny), I. Mitteilung

Peer Reviewe