Molecular Characterization of Recent and Archived Erysipelothrix rhusiopathiae Isolates

Cases of erysipelas have increased considerably in 2001–2002. Diagnosis of erysipelas is typically confirmed by culture and in a limited number of cases the isolates are serotyped. Reagents for serotyping are limited and are available only at National Veterinary Service Laboratory (NVSL). In this study, we utilize pulsed-field gel electrophoresis (PFGE) to differentiate genotypes and compare archived and recent isolates. Seventy-three erysipelas field isolates (58 recent, 15 historical) and four live vaccine strains were genetically characterized. Fortysix isolates were found to belong to genotype 1A(I), three were genotype 1A(III), each one was genotype 1A(IV), 1A(V), 1A(VI), and two isolates were designated as 1A(VII). Nine different genotypes were identified among the serotype 1b isolates [1B(I-IX)]. Within serotype 2, three genotypes were identified: 2A, 2B, and 2C. The four vaccine strains tested in this study belong to the genotype group 1A(II), closely related to genotype 1A. The vaccine strains and the most common field isolates genotype 1A(I) shared 78.6% identity based on PFGE pattern

Relating Covariant and Canonical Approaches to Triangulated Models of Quantum Gravity

In this paper explore the relation between covariant and canonical approaches to quantum gravity and $BF$ theory. We will focus on the dynamical triangulation and spin-foam models, which have in common that they can be defined in terms of sums over space-time triangulations. Our aim is to show how we can recover these covariant models from a canonical framework by providing two regularisations of the projector onto the kernel of the Hamiltonian constraint. This link is important for the understanding of the dynamics of quantum gravity. In particular, we will see how in the simplest dynamical triangulations model we can recover the Hamiltonian constraint via our definition of the projector. Our discussion of spin-foam models will show how the elementary spin-network moves in loop quantum gravity, which were originally assumed to describe the Hamiltonian constraint action, are in fact related to the time-evolution generated by the constraint. We also show that the Immirzi parameter is important for the understanding of a continuum limit of the theory.Comment: 28 pages, 10 figure

Measurement of the plasma astrophysical S factor for the 3He(D, p)4He reaction in exploding molecular clusters

The plasma astrophysical S factor for the 3He(D, p)4He fusion reaction was measured for the first time at temperatures of few keV, using the interaction of intense ultrafast laser pulses with molecular deuterium clusters mixed with 3He atoms. Different proportions of D2 and 3He or CD4 and 3He were mixed in the gas jet target in order to allow the measurement of the cross-section for the 3He(D, p)4He reaction. The yield of 14.7 MeV protons from the 3He(D, p)4He reaction was measured in order to extract the astrophysical S factor at low energies. Our result is in agreement with other S factor parameterizations found in the literature

Experimental study of fusion neutron and proton yields produced by petawatt-laser-irradiated D2-3He or CD4-3He clustering gases

We report on experiments in which the Texas Petawatt laser irradiated a mixture of deuterium or deuterated methane clusters and helium-3 gas, generating three types of nuclear fusion reactions: D(d, 3He)n, D(d, t)p and 3He(d, p)4He. We measured the yields of fusion neutrons and protons from these reactions and found them to agree with yields based on a simple cylindrical plasma model using known cross sections and measured plasma parameters. Within our measurement errors, the fusion products were isotropically distributed. Plasma temperatures, important for the cross sections, were determined by two independent methods: (1) deuterium ion time-of-flight, and (2) utilizing the ratio of neutron yield to proton yield from D(d, 3He)n and 3He(d, p)4He reactions, respectively. This experiment produced the highest ion temperature ever achieved with laser-irradiated deuterium clusters.Comment: 16 pages, 6 figure

A phenomenological description of quantum-gravity-induced space-time noise

I propose a phenomenological description of space-time foam and discuss the experimental limits that are within reach of forthcoming experiments.Comment: 10 pages, LaTex, 1 figure. Short paper, omitting most technical details. More detailed analysis was reported in gr-qc/010400

Temperature measurements of fusion plasmas produced by petawatt laser-irradiated D2-3He or CD4-3He clustering gases

Two different methods have been employed to determine the plasma temperature in a laser-cluster fusion experiment on the Texas Petawatt laser. In the first, the temperature was derived from time-of-flight data of deuterium ions ejected from exploding D2 or CD4 clusters. In the second, the temperature was measured from the ratio of the rates of two different nuclear fusion reactions occurring in the plasma at the same time: D(d, 3He)n and 3He(d, p)4He. The temperatures determined by these two methods agree well, which indicates that: i) The ion energy distribution is not significantly distorted when ions travel in the disassembling plasma; ii) The kinetic energy of deuterium ions, especially the hottest part responsible for nuclear fusion, is well described by a near-Maxwellian distribution.Comment: 13 pages, 4 figure

Attitudes towards complementary and alternative medicine in chronic pain syndromes: a questionnaire-based comparison between primary headache and low back pain

<p>Abstract</p> <p>Background</p> <p>Complementary and Alternative Medicine (CAM) is widely used and popular among patients with primary headache or low back pain (LBP). Aim of the study was to analyze attitudes of headache and LBP patients towards the use of CAM.</p> <p>Methods</p> <p>Two questionnaire-based surveys were applied comparing 432 primary headache and 194 LBP patients.</p> <p>Results</p> <p>In total, 84.75% of all patients reported use of CAM; with significantly more LBP patients. The most frequently-used CAM therapies in headache were acupuncture (71.4%), massages (56.4%), and thermotherapy (29.2%), in LBP thermotherapy (77.4%), massages (62.7%), and acupuncture (51.4%). The most frequent attitudes towards CAM use in headache vs. LBP: "leave nothing undone" (62.5% vs. 52.1%; p = 0.006), "take action against the disease" (56.8% vs. 43.2%; p = 0.006). Nearly all patients with previous experience with CAM currently use CAM in both conditions (93.6% in headache; 100% in LBP). However, the majority of the patients had no previous experience.</p> <p>Conclusion</p> <p>Understanding motivations for CAM treatment is important, because attitudes derive from wishes for non-pharmacological treatment, to be more involved in treatment and avoid side effects. Despite higher age and more permanent pain in LBP, both groups show high use of CAM with only little specific difference in preferred methods and attitudes towards CAM use. This may reflect deficits and unfulfilled goals in conventional treatment. Maybe CAM can decrease the gap between patients' expectations about pain therapy and treatment reality, considering that both conditions are often chronic diseases, causing high burdens for daily life.</p

Proton acceleration by irradiation of isolated spheres with an intense laser pulse

We report on experiments irradiating isolated plastic spheres with a peak laser intensity of 2-3 x 10(20) W cm(-2). With a laser focal spot size of 10 mu m full width half maximum (FWHM) the sphere diameter was varied between 520 nm and 19.3 mu m. Maximum proton energies of similar to 25 MeV are achieved for targets matching the focal spot size of 10 mu m in diameter or being slightly smaller. For smaller spheres the kinetic energy distributions of protons become nonmonotonic, indicating a change in the accelerating mechanism from ambipolar expansion towards a regime dominated by effects caused by Coulomb repulsion of ions. The energy conversion efficiency from laser energy to proton kinetic energy is optimized when the target diameter matches the laser focal spot size with efficiencies reaching the percent level. The change of proton acceleration efficiency with target size can be attributed to the reduced cross-sectional overlap of subfocus targets with the laser. Reported experimental observations are in line with 3D3V particle in cell simulations. They make use of well-defined targets and point out pathways for future applications and experiments.DFG via the Cluster of Excellence Munich-Centre for Advanced Photonics (MAP) Transregio SFB TR18NNSA DE-NA0002008Super-MUC pr48meIvo CermakCGC Instruments in design and realization of the Paul trap systemIMPRS-APSLMUexcellent Junior Research FundDAAD|ToIFEEuropean Union's Horizon research and innovation programme 633053Physic

Preparation For Laser Wakefield Experiments Driven By The Texas Petawatt Laser System

Laboratories around the world are planning petawatt laser driven experiments. The Texas petawatt laser offers the ability to demonstrate laser wake field acceleration (LWFA) in a unique regime with pulse duration (similar to 160 fs) shorter than other petawatt scale systems currently in operation or under development. By focusing the 1.25 PW, 200 J, 160 Is pulses to peak intensity similar to 10(19) W/cm(2), multi-GeV electron bunches can be produced from a low density He gas jet. The rarefied plasma density (5x10(16) - 10(17) cm(-3)) required for near-resonant LWFA minimizes plasma lensing and offers long dephasing length for electron acceleration over distances (similar to 10 cm) exceeding the Rayleigh range. Because of the high power, the laser can be focused to a spot (r(0) similar to 100 microns) greater than the plasma wavelength (r(0) > lambda(p)), thus minimizing radial propagation effects. Together these properties enable the laser pulse to self-guide without the use of a preformed channel lending simplicity and stability to the overall acceleration process. Particle-in-cell (PIC) simulations show the laser experiences self-focusing which, because of ultrashort pulse duration, does not lead to a collapse of the wakefield and can generate over 3 GeV electron energy. The presented material will include details of initial measurements of the Texas petawatt laser system, simulations of laser wakefield acceleration for the given laser parameters and the experimental setup currently under construction.Physic