5 research outputs found
\u3ci\u3eFoster v. Carson\u3c/i\u3e: The Ninth Circuit Misapplies the Capable-of-Retention-Yet-Evading-Review Exception to the Mootness Doctrine and Lends a Free Hand to Budget-Cutting State Officials
In Foster v. Carson, public defender organizations and indigent defendants sued the chief justice of the Oregon Supreme Court for suspending appointments of indigent defense counsel. Before the parties could fully litigate the case, the chief justice reinstated appointments. Subsequently, the United States Court of Appeals for the Ninth Circuit dismissed the case as moot and held that the exception to the mootness doctrine for cases capable-of-repetition-yet-evading-review did not apply. A case falls under that exception when the party resisting mootness demonstrates that it was not possible to fully litigate the action before it ceased and there is a reasonable expectation that the party will be subjected to the same action in the future. Because the court concluded that it was not possible to fully litigate the case before the chief justice reinstated appointments, applicability of the capable-of-repetition-yet-evading-review exception depended only on whether there was a reasonable expectation that the injury would recur. When evaluated in light of U.S. Supreme Court and Ninth Circuit precedent, the facts in Foster support a finding that there was a reasonable expectation that the chief justice would again suspend funding for indigent defense counsel. The public interest in deciding the constitutionality of the chief justice\u27s action further supports application of the exception
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Pick and Place Robotic Actuator for Big Area Additive Manufacturing
Oak Ridge National Laboratory’s Manufacturing Demonstration Facility has created a system that works
in tandem with an existing large-scale additive manufacturing (AM) system to ‘pick and place’ custom
components into a part as it is printed. Large-scale AM leaves a layered surface finish and is typically post-processed through 5-axis CNC machining. Each surface must be accurately recorded into a laser tracking
system. This process can be simplified with the use of fiducials, small location indicators placed on the surface
of a part. Additionally, the ability to monitor an AM tool via wireless sensors is advantageous to gauge part
health as it is fabricated and later used. The ‘pick and place’ system allows thermocouples, fiducials, and other
sensors to be accurately placed throughout the tool as it is fabricated. This solution has the potential to reduce
time, labor, and cost associated with fabricating, post-processing, and using AM parts.Mechanical Engineerin
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Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue
Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrative multi-omics approach, and leveraging data generated by the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we show profound sexual dimorphism in the scWAT of sedentary rats and in the dynamic response of this tissue to ExT. Specifically, the scWAT of sedentary females displays -omic signatures related to insulin signaling and adipogenesis, whereas the scWAT of sedentary males is enriched in terms related to aerobic metabolism. These sex-specific -omic signatures are preserved or amplified with ExT. Integration of multi-omic analyses with phenotypic measures identifies molecular hubs predicted to drive sexually distinct responses to training. Overall, this study underscores the powerful impact of sex on adipose tissue biology and provides a rich resource to investigate the scWAT response to ExT
Meta-Analysis of Pulsed-Field Gel Electrophoresis Fingerprints Based on a Constructed Salmonella Database
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Temporal dynamics of the multi-omic response to endurance exercise training
Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood1-3. Here, the Molecular Transducers of Physical Activity Consortium4 profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response and mitochondrial pathways. Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery. The data and analyses presented in this study will serve as valuable resources for understanding and exploring the multi-tissue molecular effects of endurance training and are provided in a public repository ( https://motrpac-data.org/ )