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Cell-to-cell variability in cell death: can systems biology help us make sense of it all?
One of the most common observations in cell death assays is that not all cells die at the same time, or at the same treatment dose. Here, using the perspective of the systems biology of apoptosis and the context of cancer treatment, we discuss possible sources of this cell-to-cell variability as well as its implications for quantitative measurements and computational models of cell death. Many different factors, both within and outside of the apoptosis signaling networks, have been correlated with the variable responses to various death-inducing treatments. Systems biology models offer us the opportunity to take a more synoptic view of the cell death process to identify multifactorial determinants of the cell death decision. Finally, with an eye toward ‘systems pharmacology', we discuss how leveraging this new understanding should help us develop combination treatment strategies to compel cancer cells toward apoptosis by manipulating either the biochemical state of cancer cells or the dynamics of signal transduction
At the intersection of idealized youth and marginalized almost-adulthood: how girls negotiate young motherhood in London, Ontario
This article discusses how young mothers in London, a mid-size city in Canada, utilize a drop-in centre service while attending an alternative programme to acquire secondary school credits. The central arguments made here are informed by key concepts in the field of girlhood studies. With its attention to the interconnections between gender, age, and generation as well as other aspects of social identity, girlhood studies provides crucial insight into the lived experiences of young mothers who straddle the space between girlhood and adulthood. We interpret the experiences of the young mothers who participated in this study in light of shifting meanings and expectations of girls and girlhood in the neoliberal era. Drawing on the concept of the ideal neoliberal girl subject embodied in the ‘can do’ and ‘at risk’ girl, this paper highlights the tensions in accessing a drop-in centre, which functions as both a site of security and surveillance, for a group of young mothers receiving social services. The findings revealed how girls who are mothers struggle to live in the present to assert a legitimate maternal identity even as they are prepared for the future through neoliberal public policies and other disciplinary practices
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