98 research outputs found
Molecular modeling and structural analysis of the Myelin basic protein-Q65ZS4.
Schizophrenia (SCZ) is a chronic, debilitating psychotic mental disorder that affects about 1 percent of the population in different countries. Scz is characterized by a series of negative and positive symptoms including psychomotor retardation, attentional impairment, decreased emotional expression, psychomotor agitation, and auditory hallucinations.X-meeting 2007
Loss of interest, depressed mood and impact on the quality of life: Cross-sectional survey
Relação entre consumo de drogas e comportamento sexual de estudantes de 2o grau de São Paulo
Clinical and biological predictors of Alzheimer's disease in patients with amnestic mild cognitive impairment
Long-term health-related quality of life improvements among patients treated with lurasidone: results from the open-label extension of a switch trial in schizophrenia
Centella asiatica water extract inhibits iPLA(2) and cPLA(2) activities in rat cerebellum
Centella asiatica (L.) Urb an is distributed widely in South America and Asia and is known as a therapeutic agent in folk medicine, capable of improving memory and treating several neurological disorders. Asiaticoside is one of the compounds found in C asiatica leaves that is suggested to be responsible for its pharmacological potential. Phospholipase A(2) (PLA(2)) is a group of enzymes that has abnormal activity in the central nervous system in some neuropsychiatric diseases. In this work, the asiaticoside present in C asiatica water extract was quantified by HPLC analysis. We also evaluated the activity of subtypes of PLA(2) in cerebellar samples from rats after C asiatica water extract treatment using a radioenzymatic assay. Asiaticoside was the major compound (84%) found in Centella water extract. We found a dose-dependent inhibitory effect of C asiatica water extract on the activity of Ca(2+)-independent PLA(2) (iPLA(2)) and cytosolic PLA(2) (cPLA(2)). The inhibition of these enzymes in the brain suggests that C asiatica may be useful to treat conditions associated with increased PLA(2) activity in the brain, such as epilepsy, stroke, multiple sclerosis and other neuropsychiatric disorders. (C) 2008 Elsevier GmbH. All rights reserved.Associacao Beneficente Alzira Denise Herzog da Silv
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