Continental degassing of helium in an active tectonic setting (northern Italy): the role of seismicity

In order to investigate the variability of helium degassing in continental regions, its release from rocks and emission into the atmosphere, here we studied the degassing of volatiles in a seismically active region of northern Italy (MwMAX = 6) at the Nirano-Regnano mud volcanic system. The emitted gases in the study area are CH4–dominated and it is the carrier for helium (He) transfer through the crust. Carbon and He isotopes unequivocally indicate that crustal-derived fluids dominate these systems. An high-resolution 3-dimensional reconstruction of the gas reservoirs feeding the observed gas emissions at the surface permits to estimate the amount of He stored in the natural reservoirs. Our study demonstrated that the in-situ production of 4He in the crust and a long-lasting diffusion through the crust are not the main processes that rule the He degassing in the region. Furthermore, we demonstrated that micro-fracturation due to the field of stress that generates the local seismicity increases the release of He from the rocks and can sustain the excess of He in the natural reservoirs respect to the steady-state diffusive degassing. These results prove that (1) the transport of volatiles through the crust can be episodic as function of rock deformation and seismicity and (2) He can be used to highlight changes in the stress field and related earthquakes

Partially Updated Switching-Method for systems of nonlinear equations

AbstractA hybrid method for solving systems of n nonlinear equations is given. The method does not use derivative information and is especially attractive when good starting points are not available and the given system is expensive to evaluate. It is shown that, after a few steps, each iteration requires (2k + 1) function evaluations where k, 1 ⩽ k ⩽ n, is chosen so as to have an efficient algorithm. Global convergence results are given and superlinear convergence is established. Some numerical results show the numerical performance of the proposed method

Seismically-induced soft-sediment deformation structures in Upper Triassic deepwater carbonates (Central Sicily)

We describe soft-sediment deformation structures into the Upper Triassic cherty limestone outcropping in the Pizzo Lupo section (Central Sicily, Italy), pertaining to the deep-water palaeodomain of the Southern Tethyan margin. In the study section, mainly consisting of thin-bedded mudstone/marl alternations with bedded chert intercalations, some lithofacies have been separated on the basis of the abundance of the calcium carbonate/clay content and the overall textural features. The deformational structures, displaying different deformational styles as folded and faulted beds, disturbed layers, clastic dikes, and slumps occur mainly in the deformed horizons that involve marl-dominated lithofacies. Small-scale water-escape structures involve beds with nodular fabric. Synsedimentary faults affect the mud-limestone dominated lithofacies, which are characterized by fault-rotating blocks producing lateral thinning. These bodies appear to have moved coherently along an overall planar surface. We relate these soft-sediment deformations to slump sheets, associated with down-slope sliding of sedimentary masses. The deformation mechanism and driving force for these soft-sediment deformations are due essentially to gravitational instability and dewatering. Detailing, rotational (slump) and translational (glide) slides and water-escape are the main processes causing the distinguished deformational styles. The synsedimentary extensional tectonics that affected the Upper Triassic pelagic deposits was the triggering process responsible for the instability of the seafloor inducing loss of coherence of the unconsolidated sediments on the sea bottom, developing a large number of gravity-driven slides. The analysis of both of these SSDSs and their relationships with the structural scenario allow us to hypothesise that they are seismically-induced

K022: Effect of combination therapy (ANG II antagonist, valsartan and a calcium channel blocker) in a hypertensive model of diabetic nephropathy

Recently, it has been suggested that in the context of diabetes and hypertension, more aggressive blood pressure targets should be considered. To achieve these levels of blood pressure control, it is likely that combination therapy will need to be used. The present study has explored the role of the addition of either a dihydropyridine or a non-dihydropyridine calcium channel blocker (CCB) to Ang II antagonist based treatment in an experimental model of hypertension and diabetes. The doses chosen for the combination therapy groups were lower than those used with monotherapy in order to achieve similar antihypertensive efficacy. Diabetic (streptozotocin induced) SHR were randomised to no treatment, valsartan (30 mg/kg/day), the non-dihydropyridine CCB verapamil (20 mg/kg/day), the dihydropyridine CCB amlodipine (6 mg/kg/day), a combination of valsartan and amlodipine (20 mg + 4 mg/kg/day respectively) or valsartan and verapamil (20 mg + 15 mg/kg/day respectively). Serial measurements of systolic blood pressure (BP) and albumin excretion rate (AER) were performed monthly (data are shown at week 16 for AER and mean of wk 20-28 for BP). This model was associated with hypertension (control, 217 ± 8, diabetic, 200 ± 5 mmHg) which was reduced by most treatments to a similar degree (valsartan 165 ± 3, amlodipine 164 ± 2, verapamil 182 ± 4, valsartan + amlodipine 151 ± 3 and valsartan + verapamil 169 ± 5 mmHg). Diabetes was associated with a progressive increase in AER (control 1.5 vs diabetic 17 mg/24 hr). Valsartan retarded the increase in AER (11 mg/24 hr). Similar efficacy was observed in the valsartan + amlodipine combination (9 mg/24 hr) but not with amlodipine alone (16 mg/24 hr) despite similar effects on blood pressure. No advantage of verapamil versus amlodipine either as monotherapy or in combination with valsartan was observed. The present study indicates that the combination of an Ang II antagonist and a dihydropyridine CCB is an effective regimen at reducing blood pressure and albuminuria in the context of diabetes and hypertensio

Spatial extent of recent vertical tectonic motions misured in NE Sicily coastal area. Insights from marine geology and coastal geomorphology studies.

Vertical position of sea-level, pointed out by related deposits and morphologies, provide useful markers to estimate tectonic uplift rates. For the Holocene very high uplift rates are misured in the northeast Sicily coast (Antonioli et al., 2009). This study compare vertical tectonic movements and marine geology data in the coastal sector between Capo d\u2019Orlando and Brolo (NE Sicily); tectonic lineaments show different trends both onland (Nigro & Sulli, 1995) and offshore (Nicolich et al.,1982) and also the morphological response follow closely this difference. The geomorphologic survey provided data on Holocene uplift rates. We studied an archaeological ancient quarry of grinding wheels for oil that has been found in the Capo d\u2019Orlando inshore (Scicchitano et al., 2011). They present semi submerged circular holes in Stilo-Capo d\u2019Orlando deposits (Carbone et al., 1998). The tectonic uplift was evaluated as the difference between the observed local paleo-sea level position and the predicted sea-level curve for the same locality (Lambeck et al., 2011). The resulting uplift rates is 0.36 mm/yr (Scicchitano et al., 2011). In this area we studied also the Brolo stack. It is a metamorphic rocks emerging at 450 m from the coastline. The study led to discovery a fossils-bearing conglomerate in protected trays at 3.5 m a.s.l.. Radiocarbon analysis on a gastropod, gave us an age of 4965 years +-70 cal BP. If we compare this data with the predicted local sea level curves (Lambeck et al., 2011), we obtain an uplift rate about 1.5 mm/yr (Lo Presti et al., 2010), which is higher than that calculated in the study of archaeological rest. A detailed study of Brolo sector show us different morphological coastline position of Brolo plain. A picture of the year 1847 shows the coastline about 200 m landward. In Brolo coastal plain we have also found a Spondylus at -6 m b.s.l. We wait for the radiocarbon dating which allows us to have a new uplift rate data. The analysis of marine geology data (Multibeam) evidenced structures connected to different faults systems, such as the submarine canyons that are the continuation of river beds. Multibeam data evidenced also tilted NE-ward submerged surfaces, indicating existing structural movements, interesting only restricted areas. So, very different uplift rates in the Holocene in very close areas distant only about 10 kilometers: both 0.36 mm/yr (Scicchitano et al. 2011) and 1.5 mm/yr (Lo Presti et al. 2010), and morphobathymetric data (tilted surfaces), evidence the important role of active tectonic lineaments. Seismic reflection profiles support this assumption, showing the metamorphic basement strongly dissected by high-angle faults, which at place determines the occurrence of emergent rock bodies (e.g. the Brolo stack). All this suggesting the occurrence of \u201crestricted regions\u201d in the coastal-marine sector with different geological behavior as response to prominent tectonic releasing bands, determining their horizontal and vertical movements

Geo-hazards of the San Vito peninsula offshore (southwestern Tyrrhenian Sea)

In this paper we present geomorphological hazard mapping of the San Vito Peninsula offshore (Sicilian margin of Tyrrhenian Sea), characterised by a very narrow continental shelf and a very dipping, tectonically active continental slope, no far from a seismogenic belt. The data set consists of morpho-bathymetric models achieved by means of multibeam survey and scattered high resolution seismic profiles. The morpho-bathymetric study highlighted some potential sites of geomorphological hazards, the most representative of which are: (i) two canyons developing from the upper slope off San Vito Cape down to the Erice basin; (ii) a dense network of small incisions across the upper slope; (iii) a very active landslide, developed onland and extending in the continental shelf close to the Scopello village. The geomorphological features that can generate submarine hazard are represented by: unstable sediment packages into canyon heads or along the upper slope; submarine canyons with regressive erosion; coastal landslides

Comparing marine geology and coastal geomorphology vertical tectonic data, a case study between Acquedolci and Patti (Messina).

The study of new data on vertical movements show a complex geologic response in a restricted sector of coastal area between Acquedolci and Patti (north-eastern Sicily). Different surveys allowed to the recognition of morphological, biological and archaeological markers of paleo-sea level. The analysis of these markers and the absolute datings performed, allowed to reconstruct the history of vertical deformation of this sector but only the comparison among coastal geomorphological data and marine geological data of platform-scarp continental system associates, allowed to find the necessary keys words to explain the geologic complexity of this sector

Angiotensin II-receptor subtypes in human atria and evidence for alterations in patients with cardiac dysfunction

Angiotensin II (All) has been implicated as an important factor in the pathophysiology of heart diseases. Following the recent identification of two subtypes of the All receptor in cardiac tissue of animals, we investigated the possible occurrence of these, or similar, subtypes in human atrial tissue. In right-atrial tissue from patients undergoing heart surgery, we determined the All-receptor profile in receptor binding studies, using [125I]-angiotensin as radioligand and All as well as two compounds selective for the receptor subtypes to identify and quantify All-receptor subpopulations. In 35 patients (23 requiring coronary bypasses, 10 vaivular surgery and two combined coronary and valvular surgery), the left-ventricular ejection fraction was determined in the preoperative phase, and right- and left-atrial pressure during surgery. In membranes of human right atria, All receptors are present in high density (median: Bmax= 294 fmol. mg−1 protein, range: 111-2073) and two different subtypes can be distinguished. Type-1 receptors (AT1) accounted for 33 ± l0% of the population whereas type-2 receptors (AT2) made up 67 ± 10% of the population. There was no correlation between any of the measured cardiac functions and total All-receptor density or receptor affinity. However, the percentage of AT1 receptors was higher in the atria of patients with normal right-atrial pressure; left-ventricular ejection fraction was positively and right-atrial pressure inversely correlated with the percentage of AT1 receptors (r=0·740 and -0·901, respectively; P<0·001, for both). Moreover, the percentage of AT receptors was directly correlated with the levels of left-atrial pressure (r=0·853; P<0·001). It is concluded that the ratio of AT1 to AT2 receptors correlates well with right-atrial pressure and left-ventricular function. This is a first indication of a possible involvement of All-receptor subtypes in the pathophysiology of cardiac dysfunction

Angiotensin II Receptor Subtypes and Cardiac Function

All the components of the renin-angiotensin system have been identified in the heart including the angiotensin II receptor subtypes AT1 and AT2 In the normal human heart, there is a decreasing receptor density from the right atrium to the left ventricle. In right atrial membranes prepared from pathological hearts, the percentage of AT1 receptor decreases with the severity of cardiac dysfunction whereas that of AT2 receptor increases. Treatment of hypertrophic rats with AT1 receptor antagonists inhibits cardiac hypertrophy and reverses the increase receptor density, indicating involvement of this Ang II receptor subtype. The role of the AT2 receptor is still largely unknown but it may be involved in cell growth and proliferation. The cloning of both AT1 and AT2 receptors as well as the availability of potent and selective antagonists will help us to understand better the functional role of Angiotensin II in cardiovascular disorder