52 research outputs found
Impact of Operational Planning on Small Business Retail Performance
This study examined operational planning activities (inventory, marketing, financial, and personnel) of successful (n=92) and failed (n= 91) small business apparel and accessory retailers. Results suggest that inventory, marketing, and financial planning activities significantly differed between groups with successful retailers being more likely than failed retailers to engage in such functions. No differences were found between groups in personnel planning. Study implications are discussed for small business practitioners and academic researchers
Development and characterization of positively selected brain-adapted SIV
HIV is found in the brains of most infected individuals but only 30% develop neurological disease. Both viral and host factors are thought to contribute to the motor and cognitive disorders resulting from HIV infection. Here, using the SIV/rhesus monkey system, we characterize the salient characteristics of the virus from the brain of animals with neuropathological disorders. Nine unique molecular clones of SIV were derived from virus released by microglia cultured from the brains of two macaques with SIV encephalitis. Sequence analysis revealed a remarkably high level of similarity between their env and nef genes as well as their 3' LTR. As this genotype was found in the brains of two separate animals, and it encoded a set of distinct amino acid changes from the infecting virus, it demonstrates the convergent evolution of the virus to a unique brain-adapted genotype. This genotype was distinct from other macrophage-tropic and neurovirulent strains of SIV. Functional characterization of virus derived from representative clones showed a robust in vitro infection of 174xCEM cells, primary macrophages and primary microglia. The infectious phenotype of this virus is distinct from that shown by other strains of SIV, potentially reflecting the method by which the virus successfully infiltrates and infects the CNS. Positive in vivo selection of a brain-adapted strain of SIV resulted in a near-homogeneous strain of virus with distinct properties that may give clues to the viral basis of neuroAIDS
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Celtic censure: representing Wales in eighteenth-century Germany
Drawing on Pierre Bourdieu's notion of regionalist discourse as the performative legitimation of specific frontiers, this article examines how the English traveller Samuel Jackson Pratt mediated a picture of the Welsh to late eighteenth-century readers in his Gleanings Through Wales, Holland and Westphalia (1795). This process of mediation was further complicated by the translation of this work into German as the Aehrenlese auf einer Reise durch Wallis, which appeared with the Leipzig publisher Lincke in 1798. While this work made an important contribution to German Celtophilia in the Romantic period, the German translator was careful to omit its more Sternean passages, in favour of factual narrative. Pratt's account of his travel through Wales, mediated in turn to a German audience through its Leipzig translator, therefore embodies several layers of cultural transfer that generate a complex and multifaceted image of Wales at the close of the eighteenth century
A review of the current treatment methods for posthaemorrhagic hydrocephalus of infants
Posthaemorrhagic hydrocephalus (PHH) is a major problem for premature infants, generally requiring lifelong care. It results from small blood clots inducing scarring within CSF channels impeding CSF circulation. Transforming growth factor – beta is released into CSF and cytokines stimulate deposition of extracellular matrix proteins which potentially obstruct CSF pathways. Prolonged raised pressures and free radical damage incur poor neurodevelopmental outcomes. The most common treatment involves permanent ventricular shunting with all its risks and consequences
Friedrich Hölderlin: Hyperion oder Der Eremit in Griechenland/Hyperion or The Hermit in Greece
‘Arise, O magnificent effulgence of Ossian's soul!’: Werther the Translator in English Translation
Hyperion, or the Hermit in Greece (PDF)
Friedrich Hölderlin’s only novel, Hyperion (1797–99), is a fictional epistolary autobiography that juxtaposes narration with critical reflection. Returning to Greece after German exile, following his part in the abortive uprising against the occupying Turks (1770), and his failure as both a lover and a revolutionary, Hyperion assumes a hermitic existence, during which he writes his letters. Confronting and commenting on his own past, with all its joy and grief, the narrator undergoes a transformation that culminates in the realisation of his true vocation.
Though Hölderlin is now established as a great lyric poet, recognition of his novel as a supreme achievement of European Romanticism has been belated in the Anglophone world. Incorporating the aesthetic evangelism that is a characteristic feature of the age, Hyperion preaches a message of redemption through beauty. The resolution of the contradictions and antinomies raised in the novel is found in the act of articulation itself. To a degree remarkable in a prose work of any length, what it means is inseparable from how it means. In this skilful translation, Gaskill conveys the beautiful music and rhythms of Hölderlin’s language to an English-speaking reader
E. T. A. Hoffmann: The Life and Opinions of the Tomcat Murr, together with a fragmentary Biography of Kapellmeister Johannes Kreisler on Random Sheets of Waste Paper
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