L' Hospidale De' Pazzi Incurabili

Marca tip. en portSign.: [cruz latina]\p4\s, A-L\p8\s, M\p7\

Plaza vniuersal de todas ciencias y artes

Encomio al arte del ilustrado doctor Ramon Llull, h. [6]-[8]En parte traducción de la obra de Tommaso Garzoni, "La piazza universale di tutte le professione del mondo"Segunda fecha tomada de colofónSign.: [cruz latina]8, A-K4, L-Z8, 2A-2Z8, 3A-3F8, 3G4Port. con orla tip. y con esc. xil. de armas de J. PerarnauTexto con apostillas marginalesInic. grab. y frisos xil

A high-risk gut microbiota configuration associates with fatal hyperinflammatory immune and metabolic responses to SARS-CoV-2.

Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and associated clinical sequelae requires well-coordinated metabolic and immune responses that limit viral spread and promote recovery of damaged systems. However, the role of the gut microbiota in regulating these responses has not been thoroughly investigated. In order to identify mechanisms underpinning microbiota interactions with host immune and metabolic systems that influence coronavirus disease 2019 (COVID-19) outcomes, we performed a multi-omics analysis on hospitalized COVID-19 patients and compared those with the most severe outcome (i.e. death, n = 41) to those with severe non-fatal disease (n = 89), or mild/moderate disease (n = 42), that recovered. A distinct subset of 8 cytokines (e.g. TSLP) and 140 metabolites (e.g. quinolinate) in sera identified those with a fatal outcome to infection. In addition, elevated levels of multiple pathobionts and lower levels of protective or anti-inflammatory microbes were observed in the fecal microbiome of those with the poorest clinical outcomes. Weighted gene correlation network analysis (WGCNA) identified modules that associated severity-associated cytokines with tryptophan metabolism, coagulation-linked fibrinopeptides, and bile acids with multiple pathobionts, such as Enterococcus. In contrast, less severe clinical outcomes are associated with clusters of anti-inflammatory microbes such as Bifidobacterium or Ruminococcus, short chain fatty acids (SCFAs) and IL-17A. Our study uncovered distinct mechanistic modules that link host and microbiome processes with fatal outcomes to SARS-CoV-2 infection. These features may be useful to identify at risk individuals, but also highlight a role for the microbiome in modifying hyperinflammatory responses to SARS-CoV-2 and other infectious agents

Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein

Emergence of SARS-CoV-2 variants diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued development of immunotherapies and vaccine immunogens resilient to viral evolution is therefore necessary. Using coldspot-guided antibody discovery, a screening approach that focuses on portions of the virus spike glycoprotein that are both functionally relevant and averse to change, we identified human neutralizing antibodies to highly conserved viral epitopes. Antibody fp.006 binds the fusion peptide and cross-reacts against coronaviruses of the four genera, including the nine human coronaviruses, through recognition of a conserved motif that includes the S2´ site of proteolytic cleavage. Antibody hr2.016 targets the stem helix and neutralizes SARS-CoV-2 variants. Antibody sd1.040 binds to subdomain 1, synergizes with antibody rbd.042 for neutralization and, like fp.006 and hr2.016, protects mice expressing human ACE2 against infection when present as bispecific antibody. Thus, coldspot-guided antibody discovery reveals donor-derived neutralizing antibodies that are cross-reactive with Orthocoronavirinae, including SARS-CoV-2 variants

Il theatro de vari e diuersi ceruelli mondani

Marca tip. en portMarca tip. na portSign.: A-Z4, Aa-Cc4, Dd2Error de fol, repite h. 35, 36, 69 y 70Texto con apostillas marginalesErro de fol, repite f. 35, 36, 69 e 70Texto con apostilas marxinai

Piazza Universale: Das ist: Allgemeiner Schauplatz/ Marckt und Zusammenkunfft aller Professionen/ Künsten/ Geschäfften/ Händeln und Handwercken/ [et]c. : Wann und von wem dieselbe erfunden: Wie sie von Tag zu Tag zugenommen: Sampt außführlicher Beschreibung alles dessen/ so darzu gehörig ...

Erstmahln durch Thomam Garzonum, Italiänisch zusammen getragen: Anjetzo aber auffs treulichste verdeutscht/ mit zugehörigen Figuren/ und unterschiedlichen Registern gezieret/ und in Druck gegeben.Nicht identisch mit VD17 39:118105R und nicht mit 1:044336U (Abweichungen auf Tbl., vgl. u.a. auch Fingerpr.)Kupfert.: Piazza Universale: oder Allgemeiner Schawplatz aller Künst, Professionen vnd HandwerckenVorlageform des Erscheinungsvermerks: Franckfurt am Mäyn/ In Verlag Matthaei Merians Sel. Erben/ Druckts Hieronymus Polich und Nicolaus Kuchenbecker. Im Jahr MDCLIX

La piazza universale di tutte le professioni del mondo, e nobili et ignobili

Sign.: a-b\p8\s, c\p6\s, A-Z\p8\s, 2A-2Z\p8\s, 3A-3N\p8\s, 3O\p4\s, 3P\p8\s, 3Q\p4\sError de pag.: p. 932 por 95