1,538 research outputs found
EXIST's Gamma-Ray Burst Sensitivity
We use semi-analytic techniques to evaluate the burst sensitivity of designs
for the EXIST hard X-ray survey mission. Applying these techniques to the
mission design proposed for the Beyond Einstein program, we find that with its
very large field-of-view and faint gamma-ray burst detection threshold, EXIST
will detect and localize approximately two bursts per day, a large fraction of
which may be at high redshift. We estimate that EXIST's maximum sensitivity
will be ~4 times greater than that of Swift's Burst Alert Telescope. Bursts
will be localized to better than 40 arcsec at threshold, with a burst position
as good as a few arcsec for strong bursts. EXIST's combination of three
different detector systems will provide spectra from 3 keV to more than 10 MeV.
Thus, EXIST will enable a major leap in the understanding of bursts, their
evolution, environment, and utility as cosmological probes.Comment: 25 pages, 10 figures, accepted by Ap
Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection
XMRV is a gammaretrovirus associated in some studies with human prostate cancer and chronic fatigue syndrome. Central to the hypothesis of XMRV as a human pathogen is the description of integration sites in DNA from prostate tumour tissues. Here we demonstrate that 2 of 14 patient-derived sites are identical to sites cloned in the same laboratory from experimentally infected DU145 cells. Identical integration sites have never previously been described in any retrovirus infection. We propose that the patient-derived sites are the result of PCR contamination. This observation further undermines the notion that XMRV is a genuine human pathogen
Effects of acute pre-treatment with ethanolamine on isoprenalineinduced myocardial infarction in adult Wistar rats
Ethanolamine (Etn), a biogenic amine, protects isolated hearts against MI, but its effects in vivo are unknown. In this study, we investigated the effects of Etn pretreatment on isoprenaline (ISO)-induced MI in vivo. Wistar rats were treated with either Etn (10mg.kg-1, i.p.) or saline, prior to either ISO (67mg.kg-1, s.c.) or saline. Haemodynamic- and electrocardiographic parameters were recorded under anaesthesia, 24 hours post-treatment with ISO. Infarct sizes were determined by triphenyltetrazolium chloride staining. Oxidative stress plasma parameters, conjugated dienes (CD) and thio-barbituric acid reactive substances (TBARS), were measured by spectrophotometric analysis. Etn decreased ISO-induced pathological Q-waves, but had no effect on ISO-induced low-voltage electrocardiogram. In addition, Etn decreased overall mortality induced by ISO treatment. However, Etn did not prevent ISO-induced infarction or the systolic- and diastolic hypotensive effects. Etn also enhanced the ISO-induced increase in heart-to-body weight ratio, and reversed the decrease in lungs-to-body weight ratio. Neither ISO nor Etn altered CD or TBARS. These results suggest that, despite a tendency to modulate cardiac electrical activity, Etn did not prevent ISO-induced MI or myocardial dysfunction in vivo
ProtoEXIST: Advanced Prototype CZT Coded Aperture Telescopes for EXIST
{\it ProtoEXIST1} is a pathfinder for the {\it EXIST-HET}, a coded aperture
hard X-ray telescope with a 4.5 m CZT detector plane a 9070 degree
field of view to be flown as the primary instrument on the {\it EXIST} mission
and is intended to monitor the full sky every 3 h in an effort to locate GRBs
and other high energy transients. {\it ProtoEXIST1} consists of a 256 cm
tiled CZT detector plane containing 4096 pixels composed of an 88 array
of individual 1.95 cm 1.95 cm 0.5 cm CZT detector modules
each with a 8 8 pixilated anode configured as a coded aperture
telescope with a fully coded field of view employing
passive side shielding and an active CsI anti-coincidence rear shield, recently
completed its maiden flight out of Ft. Sumner, NM on the 9th of October 2009.
During the duration of its 6 hour flight on-board calibration of the detector
plane was carried out utilizing a single tagged 198.8 nCi Am-241 source along
with the simultaneous measurement of the background spectrum and an observation
of Cygnus X-1. Here we recount the events of the flight and report on the
detector performance in a near space environment. We also briefly discuss {\it
ProtoEXIST2}: the next stage of detector development which employs the {\it
NuSTAR} ASIC enabling finer (3232) anode pixilation. When completed
{\it ProtoEXIST2} will consist of a 256 cm tiled array and be flown
simultaneously with the ProtoEXIST1 telescope
The Proposed High Energy Telescope (HET) for EXIST
The hard X-ray sky now being studied by INTEGRAL and Swift and soon by NuSTAR
is rich with energetic phenomena and highly variable non-thermal phenomena on a
broad range of timescales. The High Energy Telescope (HET) on the proposed
Energetic X-ray Imaging Survey Telescope (EXIST) mission will repeatedly survey
the full sky for rare and luminous hard X-ray phenomena at unprecedented
sensitivities. It will detect and localize (<20", at 5 sigma threshold) X-ray
sources quickly for immediate followup identification by two other onboard
telescopes - the Soft X-ray imager (SXI) and Optical/Infrared Telescope (IRT).
The large array (4.5 m^2) of imaging (0.6 mm pixel) CZT detectors in the HET, a
coded-aperture telescope, will provide unprecedented high sensitivity (~0.06
mCrab Full Sky in a 2 year continuous scanning survey) in the 5 - 600 keV band.
The large field of view (90 deg x 70 deg) and zenith scanning with
alternating-orbital nodding motion planned for the first 2 years of the mission
will enable nearly continuous monitoring of the full sky. A 3y followup pointed
mission phase provides deep UV-Optical-IR-Soft X-ray and Hard X-ray imaging and
spectroscopy for thousands of sources discovered in the Survey. We review the
HET design concept and report the recent progress of the CZT detector
development, which is underway through a series of balloon-borne wide-field
hard X-ray telescope experiments, ProtoEXIST. We carried out a successful
flight of the first generation of fine pixel large area CZT detectors
(ProtoEXIST1) on Oct 9, 2009. We also summarize our future plan (ProtoEXIST2 &
3) for the technology development needed for the HET.Comment: 10 pages, 13 figures, 2 tables, SPIE Conference "Astronomical
Telescopes and Instrumentation 2010"; to appear in Proceedings SPIE (2010
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