The sac evolution imaging follow-up after endovascular aortic repair: An international expert opinion-based Delphi consensus study

Objective: Management of follow-up protocols after endovascular aortic repair (EVAR) varies significantly between centers and is not standardized according to sac regression. By designing an international expert-based Delphi consensus, the study aimed to create recommendations on follow-up after EVAR according to sac evolution. Methods: Eight facilitators created appropriate statements regarding the study topic that were voted, using a 4-point Likert scale, by a selected panel of international experts using a three-round modified Delphi consensus process. Based on the experts’ responses, only those statements reaching a grade A (full agreement $75$80% and full disagreement <5%) were included in the final document. Results: One-hundred and seventy-four participants were included in the final analysis, and each voted the initial 29 statements related to the definition of sac regression (Q1-Q9), EVAR follow-up (Q10-Q14), and the assessment and role of sac regression during follow-up (Q15-Q29). At the end of the process, 2 statements (6.9%) were rejected, 9 statements (31%) received a grade B consensus strength, and 18 (62.1%) reached a grade A consensus strength. Of 27 final statements, 15 (55.6%) were classified as grade I, whereas 12 (44.4%) were classified as grade II. Experts agreed that sac regression should be considered an important indicator of EVAR success and always be assessed during follow-up after EVAR. Conclusions: Based on the elevated strength and high consistency of this international expert-based Delphi consensus, most of the statements might guide the current clinical management of follow-up after EVAR according to the sac regression. Future studies are needed to clarify debated issues. (J Vasc Surg 2024;80:937-45.

Effects of cycloleucine in the nucleus accumbens septi on the elevated plus maze test in rats

Abstract Introduction: In recent years, an important number of studies have emphasized the psychopharmacological actions of cycloleucine (1-aminocyclopentanecarboxylic acid) acting on the NR1 subunit (glycine allosteric site) of NMDA (Nmethyl-D-aspartic acid) receptor. We studied the effects of its injection in an anxiety test. Methods: The elevated plus maze test was used. Male rats bilaterally cannulated into the nucleus accumbens septi (NAS) were employed. Rats were divided into 5 groups that received either 1 µL injections of saline or cycloleucine (0.5, 1, 2, or 4 µg) 15 min before testing. Results: Time spent in the open arm was significantly increased by cycloleucine treatment with all doses (1 and 2 µg, p < 0.05; 0.5 and 4 µg, p < 0.01), like number of extreme arrivals (0.5 and 1 µg, p < 0.05; 2 µg, p < 0.01; and 4 µg, p < 0.001). Open arm entries were increased by the highest dose only (4 µg, p < 0.01). Discussion/Conclusion: Present results show no difference between all doses in the time spent in the open arm, suggesting an indirect, noncompetitive action of the drug. The increase in extreme arrivals and open arm entries suggests a dose influence in these parameters. We conclude that cycloleucine influence on the NMDA receptors within NAS leads to anxiolytic-like effects and behavioral disinhibition, which once more confirms the involvement of NAS in anxiety processing.Fil: Gargiulo, Augusto P.I.. Universidad Nacional de Cuyo; ArgentinaFil: Acuña, Andres. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Gargiulo, Mercedes Maria Lucrecia. Universidad Nacional de Cuyo; ArgentinaFil: Gargiulo, Ángel José Martín. Universidad Nacional de Cuyo; ArgentinaFil: Gargiulo, Marcos C. J.. Universidad Nacional de Cuyo; ArgentinaFil: Baiardi, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Mora, Sergio. Universidad de Chile; ChileFil: Lafuente, José Vicente. Universidad del País Vasco; EspañaFil: Romanowicz, Esteban Alejandro. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Landa, Adriana. Universidad Nacional de Cuyo; ArgentinaFil: Guevara, Manuel Alejandro. Universidad Nacional de Cuyo; ArgentinaFil: Gargiulo, Pascual Angel. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Departamento de Patología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentin

The sac evolution imaging follow-up after endovascular aortic repair: An international expert opinion-based Delphi consensus study

Objective: Management of follow-up protocols after endovascular aortic repair (EVAR) varies significantly between centers and is not standardized according to sac regression. By designing an international expert-based Delphi consensus, the study aimed to create recommendations on follow-up after EVAR according to sac evolution. Methods: Eight facilitators created appropriate statements regarding the study topic that were voted, using a 4-point Likert scale, by a selected panel of international experts using a three-round modified Delphi consensus process. Based on the experts' responses, only those statements reaching a grade A (full agreement ≥75%) or B (overall agreement ≥80% and full disagreement <5%) were included in the final document. Results: One-hundred and seventy-four participants were included in the final analysis, and each voted the initial 29 statements related to the definition of sac regression (Q1-Q9), EVAR follow-up (Q10-Q14), and the assessment and role of sac regression during follow-up (Q15-Q29). At the end of the process, 2 statements (6.9%) were rejected, 9 statements (31%) received a grade B consensus strength, and 18 (62.1%) reached a grade A consensus strength. Of 27 final statements, 15 (55.6%) were classified as grade I, whereas 12 (44.4%) were classified as grade II. Experts agreed that sac regression should be considered an important indicator of EVAR success and always be assessed during follow-up after EVAR. Conclusions: Based on the elevated strength and high consistency of this international expert-based Delphi consensus, most of the statements might guide the current clinical management of follow-up after EVAR according to the sac regression. Future studies are needed to clarify debated issues

The sac evolution imaging follow-up after endovascular aortic repair: an international expert opinion-based Delphi consensus study

objective: management of follow-up protocols after endovascular aortic repair (EVAR) varies significantly between centers and is not standardized according to sac regression. by designing an international expert-based delphi consensus, the study aimed to create recommendations on follow-up after EVAR according to sac evolution. methods: eight facilitators created appropriate statements regarding the study topic that were voted, using a 4-point Likert scale, by a selected panel of international experts using a three-round modified delphi consensus process. based on the experts' responses, only those statements reaching a grade a (full agreement &gt;= 75%) or B (overall agreement &gt;= 80% and full disagreement &lt;5%) were included in the final document. results: one-hundred and seventy-four participants were included in the final analysis, and each voted the initial 29 statements related to the definition of sac regression (Q1-Q9), EVAR follow-up (Q10-Q14), and the assessment and role of sac regression during follow-up (Q15-Q29). at the end of the process, 2 statements (6.9%) were rejected, 9 statements (31%) received a grade B consensus strength, and 18 (62.1%) reached a grade a consensus strength. Of 27 final statements, 15 (55.6%) were classified as grade I, whereas 12 (44.4%) were classified as grade II. experts agreed that sac regression should be considered an important indicator of EVAR success and always be assessed during follow-up after EVAR. conclusions: based on the elevated strength and high consistency of this international expert-based Delphi consensus, most of the statements might guide the current clinical management of follow-up after EVAR according to the sac regression. future studies are needed to clarify debated issues

K∗(892)0 and φ(1020) production at midrapidity in pp collisions at √s = 8

The production of K∗(892)0 and ϕ(1020) in pp collisions at s√ = 8 TeV were measured using Run 1 data collected by the ALICE collaboration at the LHC. The pT-differential yields d2N/dydpT in the range 0 < pT < 20 GeV/c for K∗0 and 0.4 < pT < 16 GeV/c for ϕ have been measured at midrapidity |y| < 0.5. Moreover, improved measurements of the K∗(892)0 and ϕ(1020) at s√ = 7 TeV are presented. The collision energy dependence of pT distributions, pT-integrated yields and particle ratios in inelastic pp collisions are examined. The results are also compared with different collision systems. The values of the particle ratios are measured to be similar to those found at other LHC energies. In pp collisions a hardening of the particle spectra is observed with increasing energy, but at the same time it is also observed that the relative particle abundances are independent of the collision energy. The pT-differential yields of K∗0 and ϕ in pp collisions at s√ = 8 TeV are compared with the expectations of different Monte Carlo event generators

Global polarization of Λ and ¯Λ hyperons in Pb–Pb collisions at the LHC

The global polarization of the Λ and Λ¯¯¯¯ hyperons is measured for Pb-Pb collisions at sNN−−−√ = 2.76 and 5.02 TeV recorded with the ALICE at the LHC. The results are reported differentially as a function of collision centrality and hyperon's transverse momentum (pT) for the range of centrality 5-50%, 0.5<pT<5 GeV/c, and rapidity |y|<0.5. The hyperon global polarization averaged for Pb-Pb collisions at sNN−−−√ = 2.76 and 5.02 TeV is found to be consistent with zero, ⟨PH⟩ (%) ≈ 0.01 ± 0.06 (stat.) ± 0.03 (syst.) in the collision centrality range 15-50%, where the largest signal is expected. The results are compatible with expectations based on an extrapolation from measurements at lower collision energies at RHIC, hydrodynamical model calculations, and empirical estimates based on collision energy dependence of directed flow, all of which predict the global polarization values at LHC energies of the order of 0.01%