The behavioural wedge

When nations fail to agree, can individual citizens make a difference? The third of our post-Copenhagen features is by Jonathan Gilligan, Thomas Dietz, Gerald T. Gardner, Paul C. Stern , and Michael P. Vandenbergh . They look at the effects that voluntary actions by individuals can have, and at the policies that can best encourage such actions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79202/1/j.1740-9713.2010.00405.x.pd

Structured Dictionary Learning for Energy Disaggregation

The increased awareness regarding the impact of energy consumption on the environment has led to an increased focus on reducing energy consumption. Feedback on the appliance level energy consumption can help in reducing the energy demands of the consumers. Energy disaggregation techniques are used to obtain the appliance level energy consumption from the aggregated energy consumption of a house. These techniques extract the energy consumption of an individual appliance as features and hence face the challenge of distinguishing two similar energy consuming devices. To address this challenge we develop methods that leverage the fact that some devices tend to operate concurrently at specific operation modes. The aggregated energy consumption patterns of a subgroup of devices allow us to identify the concurrent operating modes of devices in the subgroup. Thus, we design hierarchical methods to replace the task of overall energy disaggregation among the devices with a recursive disaggregation task involving device subgroups. Experiments on two real-world datasets show that our methods lead to improved performance as compared to baseline. One of our approaches, Greedy based Device Decomposition Method (GDDM) achieved up to 23.8%, 10% and 59.3% improvement in terms of micro-averaged f score, macro-averaged f score and Normalized Disaggregation Error (NDE), respectively.Comment: 10 Page

Energy and Climate Change: Key Lessons for Implementing the Behavioral Wedge

The individual and household sector accounts for roughly 40 percent of United States energy use and carbon dioxide emissions, yet the laws and policies directed at reductions from this sector often reflect a remarkably simplistic model of behavior. This Essay addresses one of the obstacles to achieving a “behavioral wedge” of individual and household emissions reductions: the lack of an accessible, brief summary for policymakers of the key findings of behavioral and social science studies on household energy behavior. The Essay does not provide a comprehensive overview of the field, but it discusses many of the leading studies that demonstrate the extent and limits of rational action. These studies can inform lawyers and policymakers who are developing measures to reduce energy use and carbon emissions and can serve as an entry point for more detailed studies of the literature. An effective response to the climate change problem will require substantial reductions in energy demand in addition to new developments in low-carbon energy supplies. The individual and household sector presents a major opportunity: the sector accounts for roughly 40% of U.S. carbon emissions and a comparable percentage of total U.S. energy production, and it is one of the most promising areas for reducing emissions. A recent analysis estimates that behavioral measures directed at this sector could reasonably be expected to reduce total US emissions by over 7% by 2020, an amount larger than the combined emissions from several of the largest-emitting industrial sectors and larger than the total emissions of France. In many cases, these emissions reductions can be achieved at less cost than the leading alternatives. Despite this opportunity, recent regulatory and policy efforts are only beginning to direct substantial attention to the individual and household sector. Findings from the social sciences provide valuable insights into how to capitalize on this opportunity, yet policymakers often have little time to develop new polices and are confronted with a barrage of often-conflicting approaches and theories. This Essay addresses the policy-making challenge by distilling the findings from a broad range of fields into several key principles for those developing energy and climate laws and policies. The principles we outline here are a starting point for policymakers working in this area. We attempt to provide insight into which principles are most relevant to law and policy, but instructions as to how to incorporate these principles are beyond the scope of this essay. The principles include only a subset of the insights from the behavioral and social science literature. In many cases, adherence to multiple principles will be necessary to develop the most effective policy design. Policymakers should consult the body of work referenced here, as well as experts in the social sciences to further their understanding of these and other principles. More extensive reviews of this literature and its relevance to energy and climate policy are also available

The Effect of Cone Opsin Mutations on Retinal Structure and the Integrity of the Photoreceptor Mosaic

Purpose. To evaluate retinal structure and photoreceptor mosaic integrity in subjects with OPN1LW and OPN1MW mutations. Methods. Eleven subjects were recruited, eight of whom have been previously described. Cone and rod density was measured using images of the photoreceptor mosaic obtained from an adaptive optics scanning light ophthalmoscope (AOSLO). Total retinal thickness, inner retinal thickness, and outer nuclear layer plus Henle fiber layer (ONL+HFL) thickness were measured using cross-sectional spectral-domain optical coherence tomography (SD-OCT) images. Molecular genetic analyses were performed to characterize the OPN1LW/OPN1MW gene array. Results. While disruptions in retinal lamination and cone mosaic structure were observed in all subjects, genotype-specific differences were also observed. For example, subjects with “L/M interchange” mutations resulting from intermixing of ancestral OPN1LW and OPN1MW genes had significant residual cone structure in the parafovea (∼25% of normal), despite widespread retinal disruption that included a large foveal lesion and thinning of the parafoveal inner retina. These subjects also reported a later-onset, progressive loss of visual function. In contrast, subjects with the C203R missense mutation presented with congenital blue cone monochromacy, with retinal lamination defects being restricted to the ONL+HFL and the degree of residual cone structure (8% of normal) being consistent with that expected for the S-cone submosaic. Conclusions. The photoreceptor phenotype associated with OPN1LW and OPN1MW mutations is highly variable. These findings have implications for the potential restoration of visual function in subjects with opsin mutations. Our study highlights the importance of high-resolution phenotyping to characterize cellular structure in inherited retinal disease; such information will be critical for selecting patients most likely to respond to therapeutic intervention and for establishing a baseline for evaluating treatment efficacy

US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report

This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference

ACC/AHA Guidelines for Coronary Artery Bypass Graft Surgery: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1991 Guidelines for Coronary Artery Bypass Graft Surgery)

The ACC/AHA Task Force on Practice Guidelines was formed to make recommendations regarding the appropriate use of diagnostic tests and therapies for patients with known or suspected cardiovascular disease. Coronary artery bypass graft (CABG) surgery is among the most common operations performed in the world and accounts for more resources expended in cardiovascular medicine than any other single procedure. Since the initial guidelines for CABG surgery were published in 1991, there has been considerable evolution in the surgical approach to coronary disease while at the same time there have been significant advances in preventive, medical, and percutaneous catheter approaches to therapy

Surface Co-Expression of Two Different PfEMP1 Antigens on Single Plasmodium falciparum-Infected Erythrocytes Facilitates Binding to ICAM1 and PECAM1

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens play a major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to malaria. The current consensus on control of variant surface antigen expression is that only one PfEMP1 encoded by one var gene is expressed per cell at a time. We measured var mRNA transcript levels by real-time Q-PCR, analysed var gene transcripts by single-cell FISH and directly compared these with PfEMP1 antigen surface expression and cytoadhesion in three different antibody-selected P. falciparum 3D7 sub-lines using live confocal microscopy, flow cytometry and in vitro adhesion assays. We found that one selected parasite sub-line simultaneously expressed two different var genes as surface antigens, on single IE. Importantly, and of physiological relevance to adhesion and malaria pathogenesis, this parasite sub-line was found to bind both CD31/PECAM1 and CD54/ICAM1 and to adhere twice as efficiently to human endothelial cells, compared to infected cells having only one PfEMP1 variant on the surface. These new results on PfEMP1 antigen expression indicate that a re-evaluation of the molecular mechanisms involved in P. falciparum adhesion and of the accepted paradigm of absolutely mutually exclusive var gene transcription is required

Cortical Mechanics and Meiosis II Completion in Mammalian Oocytes Are Mediated by Myosin-II and Ezrin-Radixin-Moesin (ERM) Proteins

Analysis of mouse oocyte mechanics shows that effective tension drops 6-fold from prophase I to metaphase II; the metaphase II egg has a 2.5-fold tension differential between the cortex over the spindle and the opposite cortex. Manipulation of actin, myosin-II, or ERMs alters tension levels and induces spindle abnormalities during meiosis II

ACC/AHA Guidelines for Coronary Artery Bypass Graft Surgery: Executive Summary and Recommendations: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1991 Guidelines for Coronary Artery Bypass Graft Surgery)

The American College of Cardiology/American Heart Association (ACC/AHA) Task Force on Practice Guidelines was formed to make recommendations regarding the appropriate use of diagnostic tests and therapies for patients with known or suspected cardiovascular disease. Coronary artery bypass graft (CABG) surgery is among the most common operations performed in the world and accounts for more resources expended in cardiovascular medicine than any other single procedure. Since the original Guidelines were published in 1991, there has been considerable evolution in the surgical approach to coronary disease, and at the same time there have been advances in preventive, medical, and percutaneous catheter approaches to therapy. These revised guidelines are based on a computerized search of the English literature since 1989, a manual search of final articles, and expert opinion