Prophylaxis of Macular Edema with Intravitreal Ranibizumab in Patients with Diabetic Retinopathy after Cataract Surgery: A Pilot Study

The purpose of this study was to evaluate the effectiveness of intravitreal ranibizumab (Lucentis, Genentech, South San Francisco, Calif, USA) combined with cataract surgery for the prevention of clinically significant macular edema (CSME) in patients with diabetic retinopathy (DR). This prospective interventional case series included fifty-four eyes of 54 patients with a previous diagnosis of nonproliferative diabetic retinopathy (NPDR) without macular edema preoperatively. Subjects were assigned in a 1 : 1 ratio to receive an intraoperative intravitreal ranibizumab injection (n = 27) or not (control group, n = 27) associated with standardised phacoemulsification surgery. The main outcome measure was the incidence of CSME one and three months after surgery. One month after surgery the incidence of CSME in the control group was 25.92% and 3.70% in the treatment group and at three months was 22.22% and 3.70%, respectively. Short-term results suggest that intravitreal ranibizumab immediately after phacoemulsification prevents CS ME in patients with NPDR

Acute endothelial failure after cosmetic iris implants (NewIris®)

We report a case of an acute endothelial failure after the implantation of a new cosmetic, colored, artificial iris diaphragm implant called NewIris®. A 21-year-old woman came to us complaining of progressive loss of vision and pain after NewIris lenses had been implanted. Decreased visual acuity, corneal edema, and increased intraocular pressure in both eyes appeared only 3 weeks after the surgery. The lenses were removed as soon as possible but had already severely affected the endothelial cell count. NewIris implants are an alternative to cosmetic contact lenses, but they are not as safe as other phakic anterior chamber intraocular lenses, nor are they a good option for the patient

Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma

PURPOSE: To identify tissue microRNAs predictive of sunitinib activity in patients with metastatic renal-cell-carcinoma (MRCC) and to evaluate in vitro their mechanism of action in sunitinib resistance. METHODS: We screened 673 microRNAs using TaqMan Low-density-Arrays (TLDAs) in tumors from MRCC patients with extreme phenotypes of marked efficacy and resistance to sunitinib, selected from an identification cohort (n = 41). The most relevant differentially expressed microRNAs were selected using bioinformatics-based target prediction analysis and quantified by qRT-PCR in tumors from patients presenting similar phenotypes selected from an independent cohort (n = 101). In vitro experiments were conducted to study the role of miR-942 in sunitinib resistance. RESULTS: TLDAs identified 64 microRNAs differentially expressed in the identification cohort. Seven candidates were quantified by qRT-PCR in the independent series. MiR-942 was the most accurate predictor of sunitinib efficacy (p = 0.0074). High expression of miR-942, miR-628-5p, miR-133a, and miR-484 was significantly associated with decreased time to progression and overall survival. These microRNAs were also overexpressed in the sunitinib resistant cell line Caki-2 in comparison with the sensitive cell line. MiR-942 overexpression in Caki-2 up-regulates MMP-9 and VEGF secretion which, in turn, promote HBMEC endothelial migration and sunitinib resistance. CONCLUSIONS: We identified differentially expressed microRNAs in MRCC patients presenting marked sensitivity or resistance to sunitinib. MiR-942 was the best predictor of efficacy. We describe a novel paracrine mechanism through which high miR-942 levels in MRCC cells up-regulates MMP-9 and VEGF secretion to enhance endothelial migration and sunitinib resistance. Our results support further validation of these miRNA in clinical confirmatory studies

COVID-19 Sequelae and the Host Pro-Inflammatory Response: An Analysis From the OnCovid Registry

Background: Fifteen percent of patients with cancer experience symptomatic sequelae, which impair post–COVID-19 outcomes. In this study, we investigated whether a proinflammatory status is associated with the development of COVID-19 sequelae. / Methods: OnCovid recruited 2795 consecutive patients who were diagnosed with Severe Acute Respiratory Syndrome Coronavirus 2 infection between February 27, 2020, and February 14, 2021. This analysis focused on COVID-19 survivors who underwent a clinical reassessment after the exclusion of patients with hematological malignancies. We evaluated the association of inflammatory markers collected at COVID-19 diagnosis with sequelae, considering the impact of previous systemic anticancer therapy. All statistical tests were 2-sided. / Results: Of 1339 eligible patients, 203 experienced at least 1 sequela (15.2%). Median baseline C-reactive protein (CRP; 77.5 mg/L vs 22.2 mg/L, P < .001), lactate dehydrogenase (310 UI/L vs 274 UI/L, P = .03), and the neutrophil to lymphocyte ratio (NLR; 6.0 vs 4.3, P = .001) were statistically significantly higher among patients who experienced sequelae, whereas no association was reported for the platelet to lymphocyte ratio and the OnCovid Inflammatory Score, which includes albumin and lymphocytes. The widest area under the ROC curve (AUC) was reported for baseline CRP (AUC = 0.66, 95% confidence interval [CI]: 0.63 to 0.69), followed by the NLR (AUC = 0.58, 95% CI: 0.55 to 0.61) and lactate dehydrogenase (AUC = 0.57, 95% CI: 0.52 to 0.61). Using a fixed categorical multivariable analysis, high CRP (odds ratio [OR] = 2.56, 95% CI: 1.67 to 3.91) and NLR (OR = 1.45, 95% CI: 1.01 to 2.10) were confirmed to be statistically significantly associated with an increased risk of sequelae. Exposure to chemotherapy was associated with a decreased risk of sequelae (OR = 0.57, 95% CI: 0.36 to 0.91), whereas no associations with immune checkpoint inhibitors, endocrine therapy, and other types of systemic anticancer therapy were found. / Conclusions: Although the association between inflammatory status, recent chemotherapy and sequelae warrants further investigation, our findings suggest that a deranged proinflammatory reaction at COVID-19 diagnosis may predict for sequelae development

New 40Ar/39Ar radiometric ages of lamproites indicate latest Tortonian marine restriction of the Fortuna Basin, Eastern Betics, southern Spain

Exposures of lamproitic volcanic rocks have been used to constrain the age of the evaporitic basin-fill in the Fortuna Basin of southern Spain. K/Ar dates initially suggested a Messinian age assignment for these deposits; however, subsequent 40Ar/39Ar dates indicated a Tortonian age, implying the early onset of evaporite formation in the eastern Betic Cordillera, in an event termed the "Tortonian Salinity Crisis". In this paper, we critically review the published chronology of the key igneous outcrops and provide new 40Ar/39Ar ages, which show that the Cabezos Negros lamproites lie close to the Tortonian-Messinian boundary (c. 7.25 ​Ma). We also provide new paleomagnetic measurements from each of the three lamproitic outcrops (Cabezos Negros, Derramadores, and El Tale), which demonstrate normal magnetic polarity coincident with episodes of volcanic and subvolcanic activity. The presence of peperites and pillow structures indicate that volcanism at Cabezos Negros was coeval with deposition of the lower part of Rambla Salada Gypsum Member. Therefore, the normal polarity identified in this unit should be equivalent to the normal polarity on the Cabezos Negros lamproites. These results indicate that the initial marine restriction and evaporitic deposition of Fortuna Basin occurred more than a million years before the Messinian Salinity Crisis

A survey to analyze the learning of geology in the Compulsory Secondary Education system of Catalonia (Spain)

The training received during primary and secondary education is crucial for the development of our behavior in adulthood. For this reason, at this early stage, it is important to know our environment and its dynamics to appreciate it. The Spanish Secondary Compulsory Education (SCE) comprises four academic years and is taken by students aged 12-16. The learning of geosciences during this level takes place only in the first, third and fourth year. Biology and geology are part of the same subject, being mandatory in the first and third year and optional in the last year. The students lose their interest in science as they advance from primary to secondary education and cease to see it as a viable option for their future (Zamalloa and Sanz, 2020). Several authors have also detected this lack of interest in science of young people (Ali et al., 2013; Christidou, 2011). This disinterest is manifested in expressions such as "Science does not provide food", "You have to study hard" or "Science is boring". To avoid this lack of motivation, educational models should be reoriented towards an educational system in which students are at the center of their learning and not simply focused on the systematic acquisition of memorized concepts to pass an exam. The discipline of Earth Sciences, or Geosciences, face a more difficult challenge than many other sciences given that students do not learn geology during early stages of their academic life (Adetunji et al., 2012). In many places such as the USA (Lewis, 2008), Australia (Dawborn-Gundlach et al., 2017), some countries of northern Europe (King, 2013), Argentina and other Latin American countries (Lacreu 2017; UNESCO, 2019) and Spain (Pedrinaci, 2012) geoscience subjects are underrepresented and frequently in the optional subjects, it is selected by students who are unmotivated. Given this context, the present study investigates the structure of geoscience education in the frame of the SCE system from Catalonia and the degree of geological knowledge acquired by the students