Engineering applications using CAD based application programming interface

Automating the design process of a product or a system can provide engineers and designers with many benefits. As such, repeatable tasks that are time consuming can be handled automatically and with minimal human attention. This is achieved by using the API (Application Programmable Interface) of CAD systems in order to create macros or even develop software applications. The present paper deals with an application that has been developed with the API of a general purposes CAD system. This application automates the design process of a standard pneumatic double acting cylinder based on the appropriate inserted parameters (ISO 15552).The design process begins with the creation of a series of components developed as solids, and extends to the extraction of basic attributes and properties from the complete mechanical assembly. Finally, the assembled models and the extracted data can be used to further study the design of the pneumatic double acting cylinder. It is expected in the future to expand the features of the presented application in order to automate the design process of other related mechanical systems

Social life-cycle assessment: A review by bibliometric analysis

This study examined the literature on social life-cycle assessment (S-LCA) published in the last 15 years (2003–2018) using bibliometric methods. Applying scientific mapping and analyzing publication performance, the study describes the structure of and trends in S-LCA publications in terms of related subject categories, authors, journals, countries, and highly cited articles. Challenges and research gaps in the S-LCA literature were also explored. The content of related papers published in the ISIWeb of Science databases was examined to identify the main themes investigated, evolution of publication activity, and most representative elements. Analyses were conducted with SciMAT software. This tool enables researchers to map research specialties by extracting qualitative information in the specialized literature and representing it using quantitative measures. The results show rapid and exponential growth of the S-LCA research line in the past ten years, with a clear upward trend in related publications (mostly case studies), especially after publication of the UNEP/SETAC Guidelines for Social Life Cycle Assessment of Products in 2009: 66% of all articles published on S-LCA were published during the period 2015–2018, primarily by European authors. The findings also delineate S-LCA as a highly fragmented research field that has been applied to diverse sectors (agriculture, bioenergy, transport, water management, chemical products, electronics, etc.), mainly in non-European countries. Critical questions concerning methods, framework, paradigms, and indicators remain to be resolved. This study provides insight into the publication performance of S-LCA, characterizing its intellectual structure and salient authors and works. In identifying hotspots in the S-LCA research, the study provides a useful state-of-the-art reference guide for academics and reveals critical research gaps and potential research avenues for future studies to advance in consolidating the discipline.This study examined the literature on social life-cycle assessment (S-LCA) published in the last 15 years (2003-2018) using bibliometric methods. Applying scientific mapping and analyzing publication performance, the study describes the structure of and trends in S-LCA publications in terms of related subject categories, authors, journals, countries, and highly cited articles. Challenges and research gaps in the S-LCA literature were also explored. The content of related papers published in the ISI Web of Science databases was examined to identify the main themes investigated, evolution of publication activity, and most representative elements. Analyses were conducted with SciMAT software. This tool enables researchers to map research specialties by extracting qualitative information in the specialized literature and representing it using quantitative measures. The results show rapid and exponential growth of the S-LCA research line in the past ten years, with a clear upward trend in related publications (mostly case studies), especially after publication of the UNEP/SETAC Guidelines for Social Life Cycle Assessment of Products in 2009: 66% of all articles published on S-LCA were published during the period 2015-2018, primarily by European authors. The findings also delineate S-LCA as a highly fragmented research field that has been applied to diverse sectors (agriculture, bioenergy, transport, water management, chemical products, electronics, etc.), mainly in non-European countries. Critical questions concerning methods, framework, paradigms, and indicators remain to be resolved. This study provides insight into the publication performance of S-LCA, characterizing its intellectual structure and salient authors and works. In identifying hotspots in the S-LCA research, the study provides a useful state-of-the-art reference guide for academics and reveals critical research gaps and potential research avenues for future studies to advance in consolidating the discipline

Social Organizational Life Cycle Assessment (SO-LCA) and Organization 4.0: An easy-to-implement method

Organizations often face difficulties when measuring their social performance. The lack of international standards, the qualitative/quantitative nature of data, and the unavailability of primary sources all hinder social impact assessments, especially in manufacturing settings. To fill these gaps, the method proposes a simple application protocol of Social Organizational Life Cycle Assessment (SO-LCA), customized for an Italian ceramic tile manufacturer. The method leverages Industry 4.0 digital technologies to collect real-time primary and site-specific social data, making the social assessment dynamic. The managerial approach adopted for the selection of social metrics and weighting of indicators and indexes, can support the transition of the manufacturing organization into Organization 4.0. The method also provides a contribution to the operational validation of the UNEP guidelines by extending their area of application. Finally, the proposed method gives substance to social responsibility through social accounting, helping the organization to measure the correct social impact starting from the detailed data, namely the decisions made in the business and in production. • Social Organizational Life Cycle Assessment (SO-LCA) application protocol validated in Industry 4.0 environment. • Social metrics directly linked to production and business processes for the dynamic assessment of social performance. • Easy replicability of the method in other organizational contexts

Infrared spectral fingerprint of neutral and charged endo- and exohedral metallofullerenes

Small metal-containing molecules have been detected and recognized as one of the hybrid species efficiently formed in space; especially in the circumstellar envelopes of evolved stars. It has been predicted also that more complex hybrid species like those formed by metals and fullerenes (metallofullerenes) could be present in such circumstellar environments. Recently, quantum-chemical simulations of metallofullerenes have shown that they are potential emitters contributing to the observed mid-IR spectra in the fullerene-rich circumstellar environments of different types of evolved stars. Here we present the individual simulated mid-IR (~5-50 um) spectra of twenty-eight metallofullerene species; both neutral and charged endo- and exohedral metallofullerenes for seven different metals (Li, Na, K, Ca, Mg, Ti, and Fe) have been considered. The changes induced by the metal-C60 interaction on the intensity and position of the spectral features are highlighted using charge density difference maps and electron density partitioning. Our calculations identify the fundamental IR spectral regions where, depending on the metal binding nature, there should be a major spectral contribution from each of the metallofullerenes. The metallofullerenes IR spectra are made publicly available to the astronomical community, especially James Webb Space Telescope users, for comparisons that could eventually lead to the detection of these species in space.Comment: Accepted for publication in The Astrophysical Journal Supplement Series on 19 September 2023 (in press) (13 pages, 7 figures, and 1 table

A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection

There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous recombination. Here we identify and characterize novel factors involved in choosing between these pathways; in this study we took advantage of the SeeSaw Reporter, in which the repair of double-strand breaks by homology-independent or -dependent mechanisms is distinguished by the accumulation of green or red fluorescence, respectively. Using a genome-wide human esiRNA (endoribonuclease- prepared siRNA) library, we isolate genes that control the recombination/endjoining ratio. Here we report that two distinct sets of genes are involved in the control of the balance between NHEJ and HR: those that are required to facilitate recombination and those that favour NHEJ. This last category includes CCAR2/DBC1, which we show inhibits recombination by limiting the initiation and the extent of DNA end resection, thereby acting as an antagonist of CtIP