FRONTAL PARIETAL NETWORK FUNCTION DURING A VISUOMOTOR TASK IN FETAL ALCOHOL SPECTRUM DISORDER: A MAGNETOENCEPHALOGRAPHY STUDY

Exposure to alcohol in utero produces a range of morphological and functional outcomes called fetal alcohol spectrum disorders (FASD). Children with FASD exhibit a broad range of cognitive disabilities. We utilized an isochronous, visuomotor, finger tapping task to probe differences in brain dynamics in adolescents, 23 diagnosed with FASD and 25 control (12-19 years of age). Data were recorded with a 306-channel magnetoencephalographic (MEG) array. A finger tapping task of 100 trains of 6 — 8 visually presented cues were presented for 350 milliseconds with interstimulus intervals of 750 milliseconds. The FASD group showed greater reaction times and reaction time variability relative to controls. Patterns of activation were extracted from the sub regions of the frontal parietal network in response locked data. Amplitude, peak onset, and peak latency differences were observed. Correlations detected between peak onsets and latencies with behavioral data reveal details about the processes occurring during the task

Information Technology Ethics - The Future of Our Jesuit Education

Address given at the dedication of the College of Computer & Information Science at Regis University on September 16, 2014

Provision of Fluoride Varnish Treatment by Medical and Dental Care Providers: Variation by Race/Ethnicity and Levels of Urban Influence

Objective: In 2004, Wisconsin Medicaid policy changed to allow medical care providers to be reimbursed for fluoride varnish treatment (FVT) to children\u27s teeth to improve access and utilization. To date, no study has been published on whether geographic and racial/ethnic variation in the provision of FVT in response to this policy change exists. This study\u27s objective is to examine the association of rates of FVT for children enrolled in Wisconsin Medicaid with race/ethnicity, urban influence codes (UIC), and dental health professional shortage area (DHPSA) designation based on county of residence. Methods: A retrospective, pre–post design was used based on FVT claims for children in the Wisconsin Medicaid program from 2002 to 2006. Poisson regression models were used to evaluate the association of rates of FVT claims with race/ethnicity, UIC, and DHPSA designation. Results: The rate of FVT claims varied by resident county-type according to UIC and DHPSA designation, age, and race/ethnicity. Post-policy, the largest increases were observed for Native Americans residing in non-DHPSA counties, enrollees living in rural counties, and for Hispanics living in partial and entire DHPSA counties. African-Americans residing in partial DHPSA and metropolitan counties displayed the lowest rates of FVT claims. Conclusions: Overall access and utilization of FVT increased, but substantial racial/ethnic and geographic variation in the provision of FVT for children enrolled in Wisconsin Medicaid was observed. Future policies should incorporate measures that will specifically address the racial and geographic variations identified in this study

Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch.

Interleukin-2 (IL-2) is a small α-helical cytokine that regulates immune cell homeostasis through its recruitment to a high-affinity heterotrimeric receptor complex (IL-2Rα/IL-2Rβ/γc). IL-2 has been shown to have therapeutic efficacy for immune diseases by preferentially expanding distinct T cell compartments, and several regulatory T cell (Treg)-biasing anti-IL-2 antibodies have been developed for combination therapies. The conformational plasticity of IL-2 plays an important role in its biological actions by modulating the strength of receptor and drug interactions. Through an NMR analysis of milliseconds-timescale dynamics of free mouse IL-2 (mIL-2), we identify a global transition to a sparse conformation which is regulated by an α-helical capping "switch" at the loop between the A and B helices (AB loop). Binding to either an anti-mouse IL-2 monoclonal antibody (mAb) or a small molecule inhibitor near the loop induces a measurable response at the core of the structure, while locking the switch to a single conformation through a designed point mutation leads to a global quenching of core dynamics accompanied by a pronounced effect in mAb binding. By elucidating key details of the long-range allosteric communication between the receptor binding surfaces and the core of the IL-2 structure, our results offer a direct blueprint for designing precision therapeutics targeting a continuum of conformational states

Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy.

ObjectivesTo examine the impact of serum-derived bovine immunoglobulin, an oral medical food known to neutralize bacterial antigen and reduce intestinal inflammation, on restoration of mucosal immunity and gastrointestinal function in individuals with HIV enteropathy.DesignOpen-label trial with intensive 8-week phase of bovine serum immunoglobulin (SBI) 2.5 g twice daily with a 4-week washout period and an optional 9-month extension study.MethodsHIV enteropathy was defined as chronic gastrointestinal symptoms including frequent loose or watery stools despite no identifiable, reversible cause. Upper endoscopy for tissue immunofluorescent antibody assay and disaccharide gut permeability/absorption studies were performed before and after 8 weeks of SBI to test mucosal immunity and gastrointestinal function. Blood was collected for markers of microbial translocation, inflammation, and collagen kinetics. A validated gastrointestinal questionnaire assessed changes in symptoms.ResultsAll eight participants experienced profound improvement in symptoms with reduced bowel movements/day (P = 0.008) and improvements in stool consistency (P = 0.008). Gut permeability was normal before and after the intervention, but D-xylose absorption increased in seven of eight participants. Mucosal CD4 lymphocyte densities increased by a median of 139.5 cells/mm2 from 213 to 322 cells/mm2 (P = 0.016). Intestinal-fatty acid binding protein (I-FABP), a marker of enterocyte damage, initially rose in seven of eight participants after 8 weeks (P = 0.039), and then fell below baseline in four of five who continued receiving SBI (P = 0.12). Baseline serum I-FABP levels were negatively correlated with subsequent rise in mucosal CD4 lymphocyte densities (r = -0.74, P = 0.046).ConclusionSBI significantly increases intestinal mucosal CD4 lymphocyte counts, improves duodenal function, and showed evidence of promoting intestinal repair in the setting of HIV enteropathy

A Search for Extraplanar Dust in Nearby Edge-On Spirals

We present high resolution BV images of 12 edge-on spiral galaxies observed with the WIYN 3.5-m telescope. These images were obtained to search for extraplanar (|z| > 0.4 kpc) absorbing dust structures similar to those previously found in NGC 891 (Howk & Savage 1997). Our imaged galaxies include a sample of seven massive L_*-like spiral galaxies within D<25 Mpc that have inclinations i > 87 deg from the plane of the sky. We find that five of these seven systems show extraplanar dust, visible as highly-structured absorbing clouds against the background stellar light of the galaxies. The more prominent structures are estimated to have associated gas masses >10^5 M_sun; the implied potential energies are > 10^(52) ergs. All of the galaxies in our sample that show detectable halpha emission at large z also show extraplanar dust structures. None of those galaxies for which extraplanar halpha searches were negative show evidence for extensive high-z dust. The existence of extraplanar dust is a common property of massive spiral galaxies. We discuss several mechanisms for shaping the observed dust features, emphasizing the possibility that these dusty clouds represent the dense phase of a multiphase medium at high-z in spiral galaxies. The correlation between high-z dust and extraplanar Halpha emission may simply suggest that both trace the high-z interstellar medium in its various forms (or phases), the existence of which may ultimately be driven by vigorous star formation in the underlying disk. (Abstract abridged)Comment: 26 pages; 15 jpeg figures. To appear in The Astronomical Journal, May 1999. Gzipped tar files of high-resolution figures in postscript and jpeg formats are available at http://www.astro.wisc.edu/~howk/Papers/papers.html#surve

XO-3b: A Massive Planet in an Eccentric Orbit Transiting an F5V Star

We report the discovery of a massive (Mpsini = 13.02 +/- 0.64 Mjup; total mass 13.25 +/- 0.64 Mjup), large (1.95 +/- 0.16 Rjup) planet in a transiting, eccentric orbit (e = 0.260 +/- 0.017) around a 10th magnitude F5V star in the constellation Camelopardalis. We designate the planet XO-3b, and the star XO-3, also known as GSC 03727-01064. The orbital period of XO-3b is 3.1915426 +/- 0.00014 days. XO-3 lacks a trigonometric distance; we estimate its distance to be 260 +/- 23 pc. The radius of XO-3 is 2.13 +/- 0.21 Rsun, its mass is 1.41 +/- 0.08 Msun, its vsini = 18.54 +/- 0.17 km/s, and its metallicity is [Fe/H] = -0.177 +/- 0.027. This system is unusual for a number of reasons. XO-3b is one of the most massive planets discovered around any star for which the orbital period is less than 10 days. The mass is near the deuterium burning limit of 13 Mjup, which is a proposed boundary between planets and brown dwarfs. Although Burrows et al. (2001) propose that formation in a disk or formation in the interstellar medium in a manner similar to stars is a more logical way to differentiate planets and brown dwarfs, our current observations are not adequate to address this distinction. XO-3b is also unusual in that its eccentricity is large given its relatively short orbital period. Both the planetary radius and the inclination are functions of the spectroscopically determined stellar radius. Analysis of the transit light curve of XO-3b suggests that the spectroscopically derived parameters may be over estimated. Though relatively noisy, the light curves favor a smaller radius in order to better match the steepness of the ingress and egress. The light curve fits imply a planetary radius of 1.25 +/- 0.15 Rjup, which would correspond to a mass of 12.03 +/- 0.46 Mjup.Comment: 26 pages, 10 figures. Accepted by ApJ. Current version has several small corrections as a result of a bug in the fitting softwar

Envisioning carbon-smart and just urban green infrastructure

To address the inter-connected climate and biodiversity crises, it is crucial to understand how multifunctional urban green infrastructure (UGI) is perceived to contribute to carbon neutrality, biodiversity, human well-being, and justice outcomes in cities. We explore how urban residents, including youth, associate carbon-related meanings with multifunctional UGI and how these meanings relate to co-benefits to biodiversity, well-being, and broader sustainability outcomes. Our findings are based on a survey distributed among urban residents of Helsinki, Finland (n = 487) and reveal how carbon-related meanings of UGI manifest at different levels of abstraction, agency, and scale, and incorporate community values and concerns attributed to the planning, features, functions, and transformational dimensions of UGI. Core carbon-related meanings of UGI emphasize either actions towards sustainability, carbon neutrality, biodiversity, or unfamiliarity towards such meanings. Perceived justice concerns and the socio-demographic contexts of the respondents covaried with carbon-related meanings associated with UGI. The results illustrate community perceptions of how it is not only possible, but rather expected, that multifunctional UGI is harnessed to tackle climate change, human well-being, and biodiversity loss in cities. Challenges for implementing the carbon-related benefits of UGI include navigating the different expectations placed on UGI and including residents with diverse socio-economic backgrounds during the process. Our findings contribute to a holistic understanding of how multifunctional UGI can help bridge policy agendas related to carbon neutrality, biodiversity protection, and human well-being that cities can implement when aiming for sustainable, just, and socially acceptable transitions towards a good Anthropocene

Predicting Progression in Parkinson's Disease Using Baseline and 1-Year Change Measures.

BackgroundImproved prediction of Parkinson's disease (PD) progression is needed to support clinical decision-making and to accelerate research trials.ObjectivesTo examine whether baseline measures and their 1-year change predict longer-term progression in early PD.MethodsParkinson's Progression Markers Initiative study data were used. Participants had disease duration ≤2 years, abnormal dopamine transporter (DAT) imaging, and were untreated with PD medications. Baseline and 1-year change in clinical, cerebrospinal fluid (CSF), and imaging measures were evaluated as candidate predictors of longer-term (up to 5 years) change in Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) score and DAT specific binding ratios (SBR) using linear mixed-effects models.ResultsAmong 413 PD participants, median follow-up was 5 years. Change in MDS-UPDRS from year-2 to last follow-up was associated with disease duration (β= 0.351; 95% CI = 0.146, 0.555), male gender (β= 3.090; 95% CI = 0.310, 5.869), and baseline (β= -0.199; 95% CI = -0.315, -0.082) and 1-year change (β= 0.540; 95% CI = 0.423, 0.658) in MDS-UPDRS; predictors in the model accounted for 17.6% of the variance in outcome. Predictors of percent change in mean SBR from year-2 to last follow-up included baseline rapid eye movement sleep behavior disorder score (β= -0.6229; 95% CI = -1.2910, 0.0452), baseline (β= 7.232; 95% CI = 2.268, 12.195) and 1-year change (β= 45.918; 95% CI = 35.994,55.843) in mean striatum SBR, and 1-year change in autonomic symptom score (β= -0.325;95% CI = -0.695, 0.045); predictors in the model accounted for 44.1% of the variance.ConclusionsBaseline clinical, CSF, and imaging measures in early PD predicted change in MDS-UPDRS and dopamine-transporter binding, but the predictive value of the models was low. Adding the short-term change of possible predictors improved the predictive value, especially for modeling change in dopamine-transporter binding