3 research outputs found
Cytotoxic prenylated indole alkaloid produced by the endophytic fungus Aspergillus terreus P63
No full textPrenyl indole alkaloids constitute a diverse class of natural products with complex chemical structures and potent biological activities. Investigation of the growth medium EtOAc extract produced by the endophytic fungus Aspergillus terreus P63 collected from roots of the grass Axonopus leptostachyus, yielded the prenylated indole alkaloid, giluterrin, bearing an unprecedented carbon skeleton. The structure of giluterrin was established by analysis of spectroscopic data and HRMS. The absolute configuration of giluterrin was determined by combination of electronic and vibrational circular dichroism analyses. Giluterrin presented antiproliferative profile for prostate (PC-3) and kidney (786-0) cancer cell lines32162167CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPsem informação2013/50228-8; 2014/25222-9National Council for Scientific and Technological Development (CNPq)National Council for Scientific and Technological Development (CNPq); National Institute of Science and Technology (INCT BioNat), Brazil [465637/2014-0]; National Institute of Science and Technology (INCT Areas Umidas), Brazil [421733/2017-9]; Sao Paulo State Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/50228-8, 2014/25222-9]; Centre for Scientific Computing (NCC/GridUNESP) of Sao Paulo State University (UNESP); FAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP
