El síndrome metabólico y su prevalencia en la población que acude a una farmacia comunitaria de Sevilla

INTRODUCCIÓN Y OBJETIVOS La prevalencia del síndrome metabólico y su repercusión cardiovascular requiere de medidas dirigidas a su prevención y control. El farmacéutico comunitario, como sanitario más próximo a la población, juega un papel fundamental en el manejo de uno de los factores más determinantes en su desarrollo: el estilo de vida. El objetivo es estimar la prevalencia del síndrome metabólico en la población que acude a las farmacias de Sevilla e identificar sus factores asociados.MÉTODOS Estudio transversal con 69 pacientes reclutados desde enero a agosto de 2008. La presencia de síndrome metabólico se determinó usando los criterios de la Federación Internacional de Diabetes.RESULTADOS La prevalencia hallada es del 33,3%. El componente más frecuente es la obesidad (53,6%), seguida por hipertensión (44,9%), hiperglucemia (40,6%), hipertrigliceridemia (34,8%) e hipocolesterolemia HDL (24,6%). El sedentarismo (p=0,002), el elevado consumo de café (p=0,036) y carnes rojas y embutidos (p=0,004), unida a la baja ingesta de pescado (p<0,001), frutas y verduras (p<0,001) y productos lácteos (p=0,027) se han identificado como factores de riesgo para su desarrollo.CONCLUSIONES La prevalencia hallada es de las más altas encontradas en España. Es necesario incidir en la adopción de hábitos de vida saludable que disminuyan su repercusión sanitaria. El farmacéutico comunitario debe aprovechar su posición estratégica para educar a la población de riesgo

Comparison between measurements and model simulations of solar radiation at a high altitude site: case studies for the Izaña BSRN Station [Póster]

Póster presentado en: International Radiation Symposium, celebrado del 6 al 10 de agosto de 2012 en Berlín, Alemania.Financial supports from the Spanish MICIIN for projects CGL2009-09740, CGL2011-23413 and CGL2010-09480E, CGL2011-13085-E are gratefully acknowledged. We authors to acknowledge the AERONET-PHOTONS-RIMA networks (http://aeronet.gsfc.nasa.gov) and the LibRadtran model (http://www.libradtran.org)

La estación BSRN de Izaña

Financial supports from the Spanish MICIIN (ref. CGL2008‐05939‐CO3‐00/CLI and CGL2009 09740) and from the GR‐220 Project of the Junta de Castilla y León are Gratefully acknowledged

Comparison between measurements and model simulations of solar radiation at a high altitude site: case studies for the Izaña BSRN Station

Financial supports from the Spanish MICIIN for projects CGL2009-09740, CGL2011-23413 and CGL2010-09480E, CGL2011-13085-E are gratefully acknowledged

Comparison of measured and modelled UV spectral irradiance at the Izaña Station based on Libradtran and UVA-GOA models

Póster elaborado para el 37th Annual European Meeting on Atmospheric Studies by Optical Methods celebrado en Valladolid los días 23-26 de agosto de 2010Financial supports from the Spanish MICIIN (ref. CGL2008-05939-CO3-00/CLI and CGL 2009-09740) and from the GR-220 Project of the Junta de Castilla y León are gratefully acknowledge

Comparación entre la irradiancia espectral UV medida experimentalmente en la estación de Izaña y simulada con los modelos de transferencia radiativa LibRadtran y UVA‐GOA

Financial supports from the Spanish MICIIN (projects CGL2008‐05939‐CO3‐00/CLI and CGL200909740) and from the GR‐220 Project of the “Junta de Castilla y León” are gratefully acknowledged

Expanding the Clinical and Molecular Heterogeneity of Nonsyndromic Inherited Retinal Dystrophies

A cohort of 172 patients diagnosed clinically with nonsyndromic retinal dystrophies, from 110 families underwent full ophthalmologic examination, including retinal imaging, electrophysiology, and optical coherence tomography, when feasible. Molecular analysis was performed using targeted next-generation sequencing (NGS). Variants were filtered and prioritized according to the minimum allele frequency, and finally classified according to the American College of Medical Genetics and Genomics guidelines. Multiplex ligation-dependent probe amplification and array comparative genomic hybridization were performed to validate copy number variations identified by NGS. The diagnostic yield of this study was 62% of studied families. Thirty novel mutations were identified. The study found phenotypic intra- and interfamilial variability in families with mutations in C1QTNF5, CERKL, and PROM1; biallelic mutations in PDE6B in a unilateral retinitis pigmentosa patient; interocular asymmetry RP in 50% of the symptomatic RPGR-mutated females; the first case with possible digenism between CNGA1 and CNGB1; and a ROM1 duplication in two unrelated retinitis pigmentosa families. Ten unrelated cases were reclassified. This study highlights the clinical utility of targeted NGS for nonsyndromic inherited retinal dystrophy cases and the importance of full ophthalmologic examination, which allows new genotypeephenotype associations and expands the knowledge of this group of disorders. Identifying the cause of disease is essential to improve patient management, provide accurate genetic counseling, and take advantage of gene therapyebased treatments. (J Mol Diagn 2020, 22: 532e543; https:// doi.org/10.1016/j.jmoldx.2020.01.003)Supported by grants from the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Health, including the Center for Biomedical Research Network on Rare Diseases (CIBERER), Fondo de Investigacion Sanitaria grant PI16/00539; the Spanish National Organization for the Blind (Fundación ONCE); and Fundación Mutua Madrileña. G.G.-G. is sponsored by the CIBERER, and A.R.-M. is supported by the Río Hortega program from ISCIII.Medicin

Description of the Baseline Surface Radiation Network (BSRN) station at the Izaña Observatory (2009–2017): measurements and quality control/assurance procedures [Discussion]

The Baseline Surface Radiation Network (BSRN) was implemented by the World Climate Research Programme (WRCP) starting observations with 9 stations in 1992, under the auspices of the World Meteorological Organization (WMO). Currently, 59 BSRN stations submit their data to the WRCP. One of these stations is the Izaña station (Station: IZA, #61) that enrolled in this network in 2009. This is a high-mountain station located in Tenerife (Canary Islands, Spain; at 28.3°N, 16.5°W, 2373ma.s.l.) and is a representative site of the subtropical North Atlantic free troposphere. It contributes with basic-BSRN radiation measurements, such as, global shortwave radiation (SWD), direct radiation (DIR), diffuse radiation (DIF) and longwave downward radiation (LWD) and extended-BSRN measurements, including ultraviolet ranges (UV-A and UV-B), shortwave upward radiation (SWU) and longwave upward radiation (LWU) and other ancillary measurements, such as vertical profiles of temperature, humidity and wind obtained from radiosonde (WMO, station #60018) and total column ozone from Brewer spectrophotometer. The IZA measurements present high quality standards since more than 98% of the data are within the limits recommended by the BSRN. There is an excellent agreement in the comparison between SWD, DIR and DIF (instantaneous and daily) measurements with simulations obtained with the LibRadtran radiative transfer model. The root mean square error (RMSE) for SWD is 2.28% for instantaneous values and 1.58% for daily values, while the RMSE for DIR is 2.00% for instantaneous values and 2.07% for daily values. IZA is a unique station that provides very accurate solar radiation data in very contrasting scenarios: most of the time under pristine sky conditions, and periodically under the effects of the Saharan Air Layer characterized by a high content of mineral dust. A detailed description of the BSRN program at IZA, including quality control and quality assurance activities, is given in this work.The IZA BSRN program has benefited from results obtained within POLARMOON project funded by the Ministerio de Economía y Competividad from Spain, CTM2015-66742-R

Characterization of an EKO MS-711 spectroradiometer: aerosol retrieval from spectral direct irradiance measurements and corrections of the circumsolar radiation [Discussion paper]

Spectral direct UV-Visible normal solar irradiance (DNI) measured with an EKO MS-711 spectroradiometer at the Izaña Atmospheric Observatory (IZO, Spain) has been used to determine aerosol optical depth (AOD) at several wavelengths (340, 380, 440, 500, 675 and 870 nm) between April and September 2019 that have been compared with synchronous AOD measurements from a reference Cimel-AERONET (Aerosol RObotic NETwork) sunphotometer. The EKO MS-711 has been calibrated at Izaña Observatory using the Langley-Plot method during the study period. Although this instrument has been designed for spectral solar DNI measurements, and therefore has a field of view (FOV) of 5° that is twice that recommended in solar photometry for AOD determination, the AOD differences compared against the AERONET Cimel reference instrument (FOV ∼ 1.2°), are fairly small. The comparison results between AOD Cimel and EKO MS-711 present a root mean square (RMS) of 0.013 (24.6 %) at 340, and 380 nm, and 0.029 (19.5 %) for longer wavelengths (440, 500, 675 and 870 nm). However, under relatively high AOD, near forward aerosol scattering might be significant because of the relatively large circumsolar radiation (CSR) due to the large EKO MS-711 FOV, resulting in a small but significant AOD underestimation in the UV range. The AOD differences decrease considerably when CSR corrections, estimated from LibRadtran radiative transfer model simulations, are performed, obtaining RMS of 0.006 (14.9 %) at 340 and 380 nm, and 0.005 (11.1 %) for longer wavelengths. The percentage of 2-minute synchronous EKO AOD–Cimel AOD differences within the World Meteorological Organization (WMO) traceability limits were ≥ 96 % at 500 nm, 675 nm and 870 nm with no CSR corrections. After applying the CSR corrections, the percentage of AOD differences within the WMO traceability limits increased to > 95 % for 380, 440, 500, 675 and 870 nm, while for 340 nm the percentage of AOD differences showed a poorer increase from 67 % to a modest 86 %.AERONET Sun photometers at Izaña have been calibrated within the AERONET Europe TNA, supported by the European Union Horizon 2020 research and innovation program under grant agreement no. 654109 (ACTRIS-2). This research benefited from the results of the project funding by MINECO RTI2018-097864-B-I00

Description of the Baseline Surface Radiation Network (BSRN) station at the Izaña Observatory (2009–2017): measurements and quality control/assurance procedures

The Baseline Surface Radiation Network (BSRN) was implemented by the World Climate Research Programme (WCRP) starting observations with nine stations in 1992, under the auspices of the World Meteorological Organization (WMO). Currently, 59 BSRN stations submit their data to the WCRP. One of these stations is the Izaña station (station IZA, no. 61) that enrolled in this network in 2009. This is a high-mountain station located in Tenerife (Canary Islands, Spain, at 28.3∘ N, 16.5∘ W; 2373 m a.s.l.) and is a representative site of the subtropical North Atlantic free troposphere. It contributes with basic-BSRN radiation measurements, such as global shortwave radiation (SWD), direct radiation (DIR), diffuse radiation (DIF) and longwave downward radiation (LWD), and extended-BSRN measurements, including ultraviolet ranges (UV-A and UV-B), shortwave upward radiation (SWU) and longwave upward radiation (LWU), and other ancillary measurements, such as vertical profiles of temperature, humidity and wind obtained from radiosonde profiles (WMO station no. 60018) and total column ozone from the Brewer spectrophotometer. The IZA measurements present high-quality standards since more than 98 % of the data are within the limits recommended by the BSRN. There is an excellent agreement in the comparison between SWD, DIR and DIF (instantaneous and daily) measurements with simulations obtained with the LibRadtran radiative transfer model. The root mean square error (RMSE) for SWD is 2.28 % for instantaneous values and 1.58 % for daily values, while the RMSE for DIR is 2.00 % for instantaneous values and 2.07 % for daily values. IZA is a unique station that provides very accurate solar radiation data in very contrasting scenarios: most of the time under pristine sky conditions and periodically under the effects of the Saharan air layer characterized by a high content of mineral dust. A detailed description of the BSRN program at IZA, including quality control and quality assurance activities, is given in this work.The IZA BSRN program has benefited from results obtained within POLARMOON project funded by the Ministerio de Economía y Competividad from Spain, CTM2015-66742-R