One Health, entornos urbanos saludables

Se presenta un proyecto de Aprendizaje servicio desarrollado entre una fundación de empresa privada del ámbito de la salud y los cuidados, y una universidad. La finalidad del proyecto es la promoción de la salud y el bienestar en el entorno urbano desde la asignatura Trabajo Fin de Grado de Grado en Fundamentos de la Arquitectura. Los estudiantes, guiados por docentes de distintos campos de conocimiento, elaboran propuestas de mejora de carácter medioambiental y social sobre unos centros de cuidados localizados en Madrid, y la empresa ofrece la información necesaria para el trabajo sobre los centros seleccionados. Esa mejora de la calidad urbana combina el proceso de aprendizaje basado en el servicio hacia la comunidad y la difusión de los resultados. La fortaleza de la iniciativa ha sido coordinar el Aprendizaje servicio de los alumnos, las alianzas interdepartamentales del profesorado universitario y la participación de la empresa privada

Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) for Twelve Antimicrobials (Biocides and Antibiotics) in Eight Strains of Listeria monocytogenes

[EN]When selecting effective doses of antimicrobials, be they biocides or antibiotics, it is essential to know the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of these substances. The present research determined the MICs and MBCs for three biocides, sodium hypochlorite (SH), benzalkonium chloride (BC), and peracetic acid (PAA), and nine antibiotics in eight strains of Listeria monocytogenes of varying serotypes. Marked intra-species differences were observed in the resistance of L. monocytogenes to the biocides and antibiotics. The MICs (ppm) for the biocides ranged between 1750 and 4500 for SH, 0.25 and 20.00 for BC, and 1050 and 1700 for PAA. Their MBCs (ppm) ranged from 2250 to 4500 for SH, 0.50 to 20.00 for BC, and 1150 to 1800 for PAA. The MICs (ppm) for antibiotics lay between 1 and 15 for ampicillin, 8 and 150 for cephalothin, 20 and 170 for cefoxitin, 0.05 and 0.20 for erythromycin, 4 and 50 for chloramphenicol, 3 and 100 for gentamicin, 2 and 15 for tetracycline, 2 and 80 for vancomycin, and 160 and 430 for fosfomycin. The corresponding MBCs (ppm) were from 5 to 20 for ampicillin, 9 to 160 for cephalothin, 70 to 200 for cefoxitin, 4 to 5 for erythromycin, 9 to 70 for chloramphenicol, 5 to 100 for gentamicin, 3 to 30 for tetracycline, 3 to 90 for vancomycin, and 160 to 450 for fosfomycin. Notably, erythromycin showed considerable efficacy, demonstrated by the low values for both MIC and MBC. Based on EUCAST and the CLSI criteria, all strains were susceptible to erythromycin. All strains were resistant to cephalothin, cefoxitin, gentamicin, and fosfomycin. Further values for resistance were 87.50% for ampicillin and vancomycin, 75.00% for tetracycline, and 62.50% for chloramphenicol. The high prevalence of antibiotic resistance is a matter for concern. A positive correlation was found between MIC and MBC values for most of the biocides and antibiotics. The higher the hydrophobicity of the cell surface, the higher the susceptibility to biocides, suggesting that surface characteristics of bacterial cells influence resistance to these compounds.SIThis research was founded by the Junta de Castilla y León (Consejería de Educación, Spain, grant number LE018P20), and the Ministerio de Ciencia, Innovación y Universidades (Spain, grant number RTI2018-098267-R-C33)

New support roller profile design for railway wheel re-profiling process by under-floor lathes with a single cutting tool

The wheel re-profiling is an important part of railway wheelset maintenance. Researchers and railway operators have been very concerned about how to minimize the loss of time during wheel re-profiling without decreasing safety. Avoiding wheelset disassembly means considerable time savings, while reducing wheel damage during operation. Underfloor wheel lathes are the most appropriate tool to achieve this double objective, and therefore the most used nowadays. Multi-cut tool lathes have the disadvantage of being extremely expensive. On the other hand, with single tool lathes, re-profiling is not smooth or safe enough when current convex profile support rollers are used. It is well known by the companies that during reprofiling the wheel suffers impacts/damaged. In this article, a methodology to optimize the profile of the support rollers used in underfloor single tool lathes for railway wheel re-profiling is proposed. This novel profile design will minimize damage and increase the safety of such lathes, since it proposes a greater smoothness in the process. Simulations of re-profiling process have been carried out by the finite element method showing that the designed roller profile reduces drastically the impact/damage during the operation. The impact generated between the re-profiling wheel and the rollers is avoided. Profile-optimized support rollers have been used in a real underfloor wheel lathe, showing good results.This work was financially supported by the Spanish Government through the MCYT project 395 “RETOS2015: sistema de monitorización integral de conjuntos mecánicos críticos para la mejora del mantenimiento en el transporte-maqstatus.

Permeation Protection by Waterproofing Mucosal Membranes

The permeability of the oral or nasal mucosa is higher than that of the skin. Mucosa permeability depends mainly on the thickness and keratinization degree of the tissues. Their permeability barrier is conditioned by the presence of certain lipids. This work has the main aim of reinforcing the barrier effect of oral mucosa with a series of formulations to reduce permeation. Transmembrane water loss of different formulations was evaluated, and three of them were selected to be tested on the sublingual mucosa permeation of drugs. Caffeine, ibuprofen, dexamethasone, and ivermectin were applied on porcine skin, mucosa, and modified mucosa in order to compare the effectiveness of the formulations. A similar permeation profile was obtained in the different membranes: caffeine > ibuprofen~dexamethasone > ivermectin. The most efficient formulation was a liposomal formulation composed of lipids that are present in the skin stratum corneum. Impermeability provided by this formulation was notable mainly for the low-molecular-weight compounds, decreasing their permeability coefficient by between 40 and 80%. The reinforcement of the barrier function of mucosa provides a reduction or prevention of the permeation of different actives, which could be extrapolated to toxic compounds such as viruses, contaminants, toxins, etc.Consejo Superior de Investigaciones Científicas “Modificación de la mucosa como protección frente al SARS-CoV-2” (CSIC-COV19-130

Effect of low doses of biocides on the antimicrobial resistance and the biofilms of Cronobacter sakazakii and Yersinia enterocolitica

The susceptibility of Cronobacter sakazakii ATCC 29544 (CS) and Yersinia enterocolitica ATCC 9610 (YE) to sodium hypochlorite (10% of active chlorine; SHY), peracetic acid (39% solution of peracetic acid in acetic acid; PAA) and benzalkonium chloride (BZK) was tested. Minimum inhibitory concentration (MIC) values (planktonic cells; microdilution broth method) of 3,800 ppm (SHY), 1,200 ppm (PAA) and 15 ppm (BZK) for CS, and 2,500 ppm (SHY), 1,275 ppm (PAA) and 20 ppm (BZK) for YE, were found. In some instances, an increase in growth rate was observed in presence of sub-MICs (0.25MIC, 0.50MIC or 0.75MIC) of biocides relative to the samples without biocides. The cultures exhibited an acquired tolerance to biocides and an increase in antibiotic resistance after exposure to sub-MICs of such disinfectants. Strains were able to form strong biofilms on polystyrene after 48 hours (confocal laser scanning microscopy), with average biovolumes in the observation field (14,161 µm2) of 242,201.0 ± 86,570.9 µm3 (CS) and 190,184.5 ± 40,860.3 µm3 (YE). Treatment of biofilms for 10 minutes with disinfectants at 1MIC or 2MIC reduced the biovolume of live cells. PAA (YE) and BZK (CS and YE) at 1MIC did not alter the percentage of dead cells relative to non-exposed biofilms, and their effect of countering biofilm was due principally to the detachment of cells. These results suggest that doses of PAA and BZK close to MICs might lead to the dissemination of live bacteria from biofilms with consequent hazards for public healthMinisterio de Ciencia, Innovación y Universidades | Ref. RTI2018-098267-R-C33Junta de Castilla y León | Ref. LE164G1

Errores en la intervención didáctica de profesores de educación física en formación: perspectiva de sus compañeros en sesiones simuladas = Mistakes on teaching intervention of trainee teachers of physical education: classmates’ perspective in simulated sessions

P. 229-235En este trabajo se investigan los errores de intervención didáctica que cometen profesores de educación física en formación durante la realización de prácticas simuladas. También se describe una experiencia centrada en la formación reflexiva mediante la investigación-acción. Se diseñó un estudio descriptivo, enmarcado en un enfoque mixto (cualitativo-cuantitativo) y retrospectivo, utilizando como fuente de información una muestra representativa de 270 informes por escrito de sesiones recogidos de 153 profesores en formación entre los cursos 2006-2007 y 2012-2013. La información fue analizada a través de un proceso de categorización en el que se diferenciaron dos categorías y veinte subcategorías. Los resultados mostraron un total de 1.482 errores, distribuidos de forma equilibrada en las categorías capacidad para dirigir la clase y habilidades para enseñar, y de forma no equilibrada en las subcategorías, destacando las relativas a organización general de la clase, adecuación de las actividades, tiempo dedicado a las tareas de aprendizaje, habilidades comunicativas, creación de un ambiente en el aula y estructuración de la sesión. El estudio concluye que las prácticas simuladas pueden aportar valor a los procesos de formación del profesorado como formas de exposición gradual a la realidad de la docencia, ayudando a observar errores de intervención didáctica a partir de los cuales es posible generar procesos de análisis y reflexión para la mejora docenteS

Spatial Algorithms for Geometric Contact Detection in Multibody System Dynamics

This article belongs to the Topic Dynamical Systems: Theory and Applications.In the present work, different algorithms for contact detection in multibody systems based on smooth contact modelling approaches are presented. Beginning with the simplest ones, some difficult interactions are subsequently introduced. In addition, a brief overview on the different kinds of contact/impact modelling is provided and an underlining of the advantages and the drawbacks of each of them is determined. Finally, some practical examples of each interaction are presented and analyzed and an outline of the issues arisen during the design process and how they have been solved in order to obtain stable and accurate results is given. The main goal of this paper is to provide a resource for the early-stage researchers in the field that serves as an introduction to the modelling of simple contact/impact events in the context of multibody system dynamics.The authors would like to acknowledge the Spanish Government through the MCYT Project "RETOS2015: sistema de monitorización integral de conjuntos mecánicos críticos para la mejora del mantenimiento en el transporte-maqstatus". The authors would also like to acknowledge the financial support received by the Community of Madrid through its multi-year agreement with University Carlos III focused on its policy "Excelencia para el Profesorado Universitario"

Dynamic Modeling of the Dissipative Contact and Friction Forces of a Passive Biped-Walking Robot

This article belongs to the Special Issue Optimization of Motion Planning and Control for Automatic Machines, Robots and Multibody Systems.This work presents and discusses a general approach for the dynamic modeling and analysis of a passive biped walking robot, with a particular focus on the feet-ground contact interaction. The main purpose of this investigation is to address the supporting foot slippage and viscoelastic dissipative contact forces of the biped robot-walking model and to develop its dynamics equations for simple and double support phases. For this investigation, special attention has been given to the detection of the contact/impact between the legs of the biped and the ground. The results have been obtained with multibody system dynamics applying forward dynamics. This study aims at examining and comparing several force models dealing with different approaches in the context of multibody system dynamics. The normal contact forces developed during the dynamic walking of the robot are evaluated using several models: Hertz, Kelvin-Voight, Hunt and Crossley, Lankarani and Nikravesh, and Flores. Thanks to this comparison, it was shown that the normal force that works best for this model is the dissipative Nonlinear Flores Contact Force Model (hysteresis damping parameter - energy dissipation). Likewise, the friction contact/impact problem is solved using the Bengisu equations. The numerical results reveal that the stable periodic solutions are robust. Integrators and resolution methods are also purchased, in order to obtain the most efficient ones for this model.This work was financially supported by the Spanish Government through the MCYT project "RETOS2015: sistema de monitorización integral de conjuntos mecánicos críticos para la mejora del mantenimiento en el transporte-maqstatus

Modelling multiple-simultaneous impact problems with a nonlinear smooth approach: pool/billiard application

Smooth approaches are able to model reasonably well contact/impact events between two bodies, showing some peculiarities when dealing with certain geometries and arising certain issues with the detection of the initial instant of contact. The characterization of multiple-simultaneous interaction systems, considering (or not) energy dissipation phenomena (mainly friction), is always an interesting research topic, addressed from different perspectives. In the present work, the process of design, optimization and verification of a multiple-impact, day-to-day multibody novel model is shown. Specifically, we have decided to focus on a pool/billiard game due to its geometry simplicity. The model involves several balls moving freely and rolling, suffering different kinds of contacts/impacts among them and against the cushions and the cloth. In this system, the proper modelling of both contact and friction forces in the multiple, simultaneous contacts and impacts events is critical to obtain consistent results. In addition, these forces are complicated to model because of its nonlinear behaviour. The different existing approaches when dealing with multiple-contact events are briefly described, along with their most distinctive features. Then, the interactions identified on the model are implemented using several nonlinear contact-force models, following a smooth-based approach and considering friction phenomena, aiming at determining the most suitable set of both contact and friction force models for each of these implemented interactions, which take place simultaneously, thus resulting in a complex system with multiple impacts. Subsequently, the solving method that provides the most accurate results at the minimum computational cost is determined by testing a simple shot. Finally, the different interactions on the model are verified using experimental results and previous works. One of the main goals of this work is to show the some of the issues that arise when dealing with multiple-simultaneous impact multibody systems from a smooth-contact approach, and how researchers can deal with them.The authors would like to thank the Spanish Government through the MCYT Project "RETOS2015: sistema de monitorización integral de conjuntos mecánicos críticos para la mejora del mantenimiento en el transportemaqstatus". The authors would also like to acknowledge the support received by the Community of Madrid through its multiyear agreement with University Carlos III focused on its policy "Excelencia para el Profesorado Universitario". Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature