64 research outputs found
Superfluid drag of two-species Bose-Einstein condensates in optical lattices
We study two-species Bose-Einstein condensates in quasi two-dimensional
optical lattices of varying geometry and potential depth. Based on the
numerically exact Bloch and Wannier functions obtained using the plane-wave
expansion method, we quantify the drag (entrainment coupling) between the
condensate components. This drag originates from the (short range)
inter-species interaction and increases with the kinetic energy. As a result of
the interplay between interaction and kinetic energy effects, the
superfluid-drag coefficient shows a non-monotonic dependence on the lattice
depth. To make contact with future experiments, we quantitatively investigate
the drag for mass ratios corresponding to relevant atomic species.Comment: 6 pages, 4 figures. Accepted in its original form but minor changes
have been don
Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits
Phenotypic heterogeneity in monogenic neurodevelopmental disorders can arise from differential severity of variants underlying disease, but how distinct alleles drive variable disease presentation is not well understood. Here, we investigate missense mutations in DNA methyltransferase 3A (DNMT3A), a DNA methyltransferase associated with overgrowth, intellectual disability, and autism, to uncover molecular correlates of phenotypic heterogeneity. We generate a Dnmt3
Computed Tomography Imaging of Primary Lung Cancer in Mice Using a Liposomal-Iodinated Contrast Agent
To investigate the utility of a liposomal-iodinated nanoparticle contrast agent and computed tomography (CT) imaging for characterization of primary nodules in genetically engineered mouse models of non-small cell lung cancer.Primary lung cancers with mutations in K-ras alone (Kras(LA1)) or in combination with p53 (LSL-Kras(G12D);p53(FL/FL)) were generated. A liposomal-iodine contrast agent containing 120 mg Iodine/mL was administered systemically at a dose of 16 µl/gm body weight. Longitudinal micro-CT imaging with cardio-respiratory gating was performed pre-contrast and at 0 hr, day 3, and day 7 post-contrast administration. CT-derived nodule sizes were used to assess tumor growth. Signal attenuation was measured in individual nodules to study dynamic enhancement of lung nodules.A good correlation was seen between volume and diameter-based assessment of nodules (R(2)>0.8) for both lung cancer models. The LSL-Kras(G12D);p53(FL/FL) model showed rapid growth as demonstrated by systemically higher volume changes compared to the lung nodules in Kras(LA1) mice (p<0.05). Early phase imaging using the nanoparticle contrast agent enabled visualization of nodule blood supply. Delayed-phase imaging demonstrated significant differential signal enhancement in the lung nodules of LSL-Kras(G12D);p53(FL/FL) mice compared to nodules in Kras(LA1) mice (p<0.05) indicating higher uptake and accumulation of the nanoparticle contrast agent in rapidly growing nodules.The nanoparticle iodinated contrast agent enabled visualization of blood supply to the nodules during the early-phase imaging. Delayed-phase imaging enabled characterization of slow growing and rapidly growing nodules based on signal enhancement. The use of this agent could facilitate early detection and diagnosis of pulmonary lesions as well as have implications on treatment response and monitoring
Intermediate-Range Order of Alkali Disilicate Glasses and Its Relation to the Devitrification Mechanism
Algorithm 535: The QZ algorithm to solve the generalized eigenvalue problem for complex matrices [F2]
Improving the efficiency of matrix operations in the numerical solution of large implicit systems of linear differential equations
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