Genotype f prevails in Venezuelan urban patients with chronic hepatitis B(a)(a)This project was supported, in part, by an award to Intediag-HV granted by Fondo Pro-Salud 2007, Cámara Venezolana de Fabricantes de Cerveza (CAVEFACE), Venezuela. A preliminary report of this work was presented in an abstract form at the 13th International Symposium on Viral Hepatitis and Liver Disease, March, 2009, Washington, USA. www.ishld2009.org/pdf/ISVHLD_Poster_Presentation_Abstractspdf

Hepatitis B virus (HBV) has been classified into 8 genotypes (A-H). Genotypes A, D and F have been identified in some South American countries, but in Venezuela studies have been more restricted to aboriginal communities where genotype F is predominant. The aim of the present study was to identify the prevalence of HBV genotypes among native HBsAg carriers in Venezuelan urban areas. In addition, we correlated the predominant HBV genotype with epidemiological, serological and virological features of the infection. Non-Venezuelan migrant patients were excluded from this study. Serum samples from 90 patients (21 children and 69 adults) with chronic hepatitis B (CHB) were analyzed. Seventy-four patients had CHB e-antigen positive and 16 CHB e-antigen negative. HBV DNA serum levels of the whole group ranged from 4.1 to 8.8 log1H IU/mL. Patients with CHB e-antigen positive showed significantly higher viral loads (P = 0.0001) than the group with CHB e-antigen negative. Eighty-eight patients (97.8%) exhibited HBV genotype F while two non-related patients (2.2%) were infected with A + F genotypes. Genotype F is the main circulating HBV strain among HBsAg carriers from Venezuelan urban areas. This genotype is associated mostly with CHB e-antigen positive and high rate of transmission. Progression to cirrhosis and hepatocellular carcinoma could be major clinical events of this patient population independently of age at acquisition or transmission route

A comparative analysis of the Spanish and Latin-American prospective drug-induced liver injury (DILI) networks

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