Conformity behavior in crises: evidence from the COVID-19 epidemic in China

Once a mass health crisis breaks out, it causes concern among whole societies. Thus, understanding the individual’s behavior in response to such events is key in government crisis management. From the perspective of social influence theory, this study adopts the empirical research method to collect data information in February 2020 through online survey, with a view to comprehensively describe the individuals’conformity behavior during the COVID-19 outbreak in China. The individual’s conformity behavior and new influencing factors were identified. The results revealed that affective risk perception, cognitive risk perception, and individual risk knowledge had a positive significant impact on normative influence. Affective risk perception and individual risk knowledge had a positive significant on informative influence. Cognitive risk perception did not significantly impact informative influence. Informative influence and normative influence had a positive effect on conformity behavior. These results have significant implications for the management behavior of the government

Single-cell transcriptomic analysis reveals heterogeneous features of myeloid-derived suppressor cells in newborns

The transitory emergence of myeloid-derived suppressor cells (MDSCs) in infants is important for the homeostasis of the immune system in early life. The composition and functional heterogeneity of MDSCs in newborns remain elusive, hampering the understanding of the importance of MDSCs in neonates. In this study, we unraveled the maturation trajectory of polymorphonuclear (PMN)-MDSCs from the peripheral blood of human newborns by performing single-cell RNA sequencing. Results indicated that neonatal PMN-MDSCs differentiated from self-renewal progenitors, antimicrobial PMN-MDSCs, and immunosuppressive PMN-MDSCs to late PMN-MDSCs with reduced antimicrobial capacity. We also established a simple framework to distinguish these distinct stages by CD177 and CXCR2. Importantly, preterm newborns displayed a reduced abundance of classical PMN-MDSCs but increased late PMN-MDSCs, consistent with their higher susceptibility to infections and inflammation. Furthermore, newborn PMN-MDSCs were distinct from those from cancer patients, which displayed minimum expression of genes about antimicrobial capacity. This study indicates that the heterogeneity of PMN-MDSCs is associated with the maturity of human newborns

BRPF1-KAT6A/KAT6B Complex: Molecular Structure, Biological Function and Human Disease

The bromodomain and PHD finger–containing protein1 (BRPF1) is a member of family IV of the bromodomain-containing proteins that participate in the post-translational modification of histones. It functions in the form of a tetrameric complex with a monocytic leukemia zinc finger protein (MOZ or KAT6A), MOZ-related factor (MORF or KAT6B) or HAT bound to ORC1 (HBO1 or KAT7) and two small non-catalytic proteins, the inhibitor of growth 5 (ING5) or the paralog ING4 and MYST/Esa1-associated factor 6 (MEAF6). Mounting studies have demonstrated that all the four core subunits play crucial roles in different biological processes across diverse species, such as embryonic development, forebrain development, skeletal patterning and hematopoiesis. BRPF1, KAT6A and KAT6B mutations were identified as the cause of neurodevelopmental disorders, leukemia, medulloblastoma and other types of cancer, with germline mutations associated with neurodevelopmental disorders displaying intellectual disability, and somatic variants associated with leukemia, medulloblastoma and other cancers. In this paper, we depict the molecular structures and biological functions of the BRPF1-KAT6A/KAT6B complex, summarize the variants of the complex related to neurodevelopmental disorders and cancers and discuss future research directions and therapeutic potentials

The study for public management policy utility evaluation and optimization system under the framework of social computing perspective

© 2001-2011 IEEE. In recent years, in order to rationalize the allocation of social resources and optimize the implementation of public management policies, scholars have conducted in-depth researches on policy effectiveness. However, at present, most of the study is still at the level of using macrolevel qualitative analysis, and lack of quantitative analysis and evaluation system for the effectiveness of policy implementation. The goal of this article is to discuss the utility evaluation system of public management policy from the perspective of social computing. First, based on the data obtained through questionnaire survey, we obtain indicators of the survey data by using factor analysis, and a new BDI (belief-desire-intention) model is created based on the observation indicators, and then the simulation platform is constructed; then, a brand new quantitative analysis method for policy optimization is proposed by using modified logistic functions as a tool. As application, we conducted the case study for the Targeted poverty alleviation policy in Yulin region (Guangxi, China), in which the key indicators for the poverty were established, and then the policy optimization suggestions were given based on the results of simulation experiments. This case study has Chinese characteristics, which might be applied to the poverty alleviation work globally

ST-HO: Symmetry-Enhanced Energy-Efficient DAG Task Offloading Algorithm in Intelligent Transport System

In Intelligent Transport Systems (ITSs), Internet of Vehicles (IoV) communications and computation offloading technology have been introduced to assist with the burdensome sensing task processing, thus prompting a new design paradigm called mobile sensing–communication–computation (MSCC) synergy. Most researchers have focused on offloading strategy design to reduce energy consumption or execution costs, but ignore the intrinsic characteristics of tasks, which may lead to poor performance. This paper studies the offloading strategy of vehicle MSCC tasks represented by a Directed Acyclic Graph (DAG) structure. According to the DAG dependency of the subtasks, this paper proposes a computation offloading strategy to optimize energy consumption under time constraints. An energy consumption model for task execution is established. Then, the Simulated Annealing and Tabu Search hybrid optimization algorithm (ST-HO) is designed to solve the problem of minimizing the energy consumption. Crucially, this research integrates the concept of symmetry into the typical DAG structure of MSCC tasks, ensuring the integrity and efficiency of task execution in ITS. The simulation results show that ST-HO reduces energy consumption by at least 5.58% compared to the conventional algorithm. Particularly, the convergence speed of ST-HO is improved by 52.63% when the replication strategy of symmetric task is considered

Dendrobium officinale Polysaccharides Inhibit 1-Methyl-2-Nitro-1-Nitrosoguanidine Induced Precancerous Lesions of Gastric Cancer in Rats through Regulating Wnt/β-Catenin Pathway and Altering Serum Endogenous Metabolites

Dendrobium officinale is a herb in traditional Chinese medicine where D. officinale polysaccharides (DOP) are the main active ingredient. This study aimed at evaluating DOP efficiency at inhibiting 1-Methyl-2-nitro-1-nitrosoguanidine (MNNG) induced precancerous lesions of gastric cancer (PLGC) in rats through the Wnt/b-catenin pathway and analyzing the variations of serum endogenous metabolites. PLGC was established in male Sprague-Dawley (SD) rats by administering 150 μg/mL MNNG in drinking water for 7 months and giving 0.1 mL of 10% NaCl once weekly during the initial 20 weeks. Treatment with DOP inhibited the progress of PLGC through decreasing the expression of β-catenin by immunohistochemical analysis. The futher study indicated DOP downregulated gene expression of Wnt2β, Gsk3β, PCNA, CyclinD1, and β-catenin, as well as protein expression of Wnt2β, PCNA, and β-catenin. On the other hand, there were nine endogenous metabolites identified after the DOP treatment. Among these, the most significant one is betaine because of its strong antioxidant activity, leading to an anti-tumor effect. DOP can inhibit MNNG-induced PLGC models via regulating Wnt/β-catenin pathway and by changing endogenous metabolites

Experimental Investigation on the Influence of Regional Concrete Spalling on Shield Tunnel Segments

Based on the field investigation and analysis, the mechanical characteristics of segment structure in shield tunnels are compared and analyzed under the circumstances of different concrete spalling region by the method of similarity model experiment. Through data analysis of acoustic emission, the results for displacement and internal force of shield tunnel segments are clarified on the segment lining, the influential rule of load bearing capacity is also determined, and the deformation and stress for the different concrete spalling region are described as well. The corresponding research results indicate that range for elastic bearing stage is enlarged while it is narrowed for plastic bearing stage, the convergence and deformation and the accumulated event numbers for acoustic emission on critical instability point are obviously increasing, and the process of damage and failure tends to be sudden for segment lining structure. The ultimate bearing capacity of the damaged segment lining obviously decreases due to regional concrete spalling; to be more specific, the reduction rate for ultimate bearing capacity becomes 6%, 6%, and 13%, respectively, when the range of concrete spalling reaches 45°, 60°, and 75°

Monitoring of the regulatory ability and regulatory state of the autonomic nervous system and its application to the management of hypertensive patients: a study protocol for randomised controlled trials

Introduction Many causes lead to sympathetic-vagus imbalance, which promotes the development of hypertension and accelerates the process of target organ damage. Many studies have shown that exercise training and heart rate variability (HRV) biofeedback can improve diseases caused by autonomic nerve dysfunction, such as hypertension. Based on these theories and the Yin-Yang balance theory of traditional Chinese medicine and Cannon’s homeostasis theory, we have developed an assessment system of autonomic nerve regulation system and a harmony instrument. In this study, we aimed to find a new way to control blood pressure of hypertensive patients via cardiopulmonary resonance indices-based respiratory feedback training.Methods and analysis This is a prospective, randomised, parallel-controlled clinical trial, which aims to evaluate the effectiveness and safety of biofeedback therapy and exercise rehabilitation combined intervention in hypertension management. 176 healthy individuals will be recruited to get their autonomic nerve function parameters as normal control, while 352 hypertensive patients will be enrolled and randomly divided into a conventional treatment group and an experiment group in a ratio of 1:1. All patients will continue to receive standard hypertension blood pressure treatment, except that patients in the experiment group will have to complete additional daily respiratory training for 6 months. The primary outcome is the difference of clinical systolic blood pressure (SBP) between the two groups after 6 months of intervention. The secondary outcomes include the changes in the mean SBP and diastolic blood pressure (DBP) by 24-hour blood pressure monitoring, home SBP, clinical and home DBP, clinical and home heart rate, the standard-reaching rate of clinic and home SBP and the incidence of composite endpoint events at 6 months.Ethics and dissemination This study has been approved by the clinical research ethics committee of China-Japan Friendship Hospital (No. 2018-132 K98-2), the results of this study will be disseminated via peer-reviewed publications or conference presentations.Trial registration number Chinese Clinical Trial Registry, ChiCTR1800019457, registered on 12 August 2018

Electroactive liquid crystal elastomers

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High‐efficiency thermally activated delayed fluorescence materials via a shamrock‐shaped design strategy to enable OLEDs with external quantum efficiency over 38%

Abstract To achieve highly‐efficient organic light‐emitting diodes (OLEDs), great efforts have been devoted into constructing thermally activated delayed fluorescence (TADF) with high horizontal dipole ratios (Θ//). Here, we proposed a design strategy by integrating a rigid electron‐accepting oxygen‐bridged boron core with triple electron‐donating groups, which exhibited a “shamrock‐shape”, namely BO‐3DMAC and BO‐3DPAC. Benefiting from the rigid and large‐planar skeletons brought by shamrock‐shaped design, BO‐3DMAC and BO‐3DPAC exhibit high Θ// of 84%/70% and 93%/94% in neat/doped films, respectively, and finally furnish excellent external quantum efficiencies (EQEs) of up to 28.3% and 38.7% in 20 wt% doped OLEDs with sky‐blue emission, as well as adequate EQEs of up to 21.0% and 16.7% in nondoped OLEDs. This work unveils a promising strategy to establish high‐Θ// TADF emitters by constructing large‐planar molecular structures using shamrock‐shaped design