Lead Biomarkers, Serum Iron Indices and Genotypes by Exposure [Mean ± SD or N (%) or M (P₂₅, P₇₅)].

<p>Abbreviations: BPb, blood lead; UPb, urine lead; ZPP, zinc protoporphyrin; sFe, serum iron; UIBC, unsaturated iron-binding capacity; TIBC, total iron binding capacity; Tf, transferrin; TfS, serum transferrin saturation; sFn, serum ferritin; sTfR, soluble transferrin receptor; BIC, body iron content; Hb, haemoglobin. For <i>H63D</i> genotype, HH, wild-type; HD, <i>H63D</i> heterozygous variant; DD, <i>H63D</i> homozygous variant. For <i>C282Y</i> genotype, CC, wild-type; CY, <i>C282Y</i> heterozygous variant; YY, <i>C282Y</i> homozygous variant.</p><p>*(**) <i>p<0.05</i> (<i>0.01</i>) (Chi-square test, Student's <i>t</i>-test or nonparametric test) compared with the unexposed group of the same sex.</p><p>Results were expressed as the mean ± SD when continuous variables followed a normal distribution.</p><p>Results were expressed as M (P₂₅, P₇₅) when continuous variables did not follow a normal distribution.</p

Interactive effect between the <i>H63D</i> genotype and blood lead levels on transferrin.

<p><i>H63D</i> genotype: HD or DD: open dots, dashed line; HH: close dots, full line. The data are analyzed using multivariate analysis.</p

Demographic Characteristics of Subjects by Exposure [M(P₂₅, P₇₅)or N(%)].

<p>*(**) <i>p<0.05</i> (<i>0.01</i>) (Chi-square test or nonparametric test) compared with the unexposed group of the same sex.</p><p>Results were expressed as the mean ± SD when the continuous variables followed a normal distribution.</p><p>Results were expressed as M (P25, P75) when the continuous variables did not follow a normal distribution.</p

Lead Biomarkers and Serum Iron Indices by <i>HFE</i> Genotypes [Mean ±SD or N or M (P₂₅, P₇₅)].

<p>Abbreviations: BPb, blood lead; UPb, urine lead; ZPP, zinc protoporphyrin; sFe, serum iron; UIBC, unsaturated iron-binding capacity; TIBC, total iron binding capacity; Tf, transferrin; TfS, serum transferrin saturation; sFn, serum ferritin; sTfR, soluble transferrin receptor; BIC, body iron content; Hb, haemoglobin; HH, wild-type; HD, <i>H63D</i> heterozygous variant; DD, <i>H63D</i> homozygous variant.</p><p>*(**) <i>p<0.05</i> (<i>0.01</i>) compared with <i>HH</i> (student's <i>t</i>-test or nonparametric test).</p>a<p>Because of missing data, the numbers do not equal 771.</p><p>Results were expressed as the mean ± SD when continuous variables followed a normal distribution.</p><p>Results were expressed as M (P₂₅, P₇₅) when continuous variables did not follow a normal distribution.</p

Linear regression models evaluating effect of <i>HFE</i> genotypes on the association between lead exposure and iron metabolism.

<p>Abbreviations: BPb, blood lead; Tf, transferrin; BIC, body iron content; HH, wild-type; HD, <i>H63D</i> heterozygous variant; DD, <i>H63D</i> homozygous variant.</p><p>Linear models were adjusted stepwise for age (year), gender (male vs. female), education (lower than high school vs. higher than high school), marriage (yes vs. no), tobacco use (yes vs. no), alcohol consumption (yes vs. no), occupational lead exposure (unexposed, dissolved lead operations or electrolytic lead operations) and work years. <i>H63D</i> genotype (HH vs. HD or DD), iron metabolic index/BPb and the cross-product with the genotype and each iron metabolic index/BPb. While BPb was independent factor, each iron metabolic index and the cross-product with the genotype were put separately into the model.</p>1<p><i>P</i> value for each statistic;</p>2<p><i>P</i> value for each regression model.</p

Interactive effect between the <i>H63D</i> genotype and body iron content on blood lead levels.

<p><i>H63D</i> genotype: HD or DD: open dots, dashed line; HH: close dots, full line. The data are analyzed using multivariate analysis.</p

Interactive effect between the <i>H63D</i> genotype and blood lead levels on body iron content.

<p><i>H63D</i> genotype: HD or DD: open dots, dashed line; HH: close dots, full line. The data are analyzed using multivariate analysis.</p