1 research outputs found
Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels
Synthetic
reactive oxygen species (ROS)-responsive biomaterials have emerged
as a useful platform for regulating critical aspects of ROS-induced
pathologies and can improve such hostile microenvironments. Here,
we report a series of new hyperbranched poly(β-hydrazide ester)
macromers (HB-PBHEs) with disulfide moieties synthesized via an “A2
+ B4” Michael addition approach. The three-dimensional structure
of HB-PBHEs with multiacrylate end groups endows the macromers with
rapid gelation capabilities to form (1) injectable hydrogels via cross-linking
with thiolated hyaluronic acid and (2) robust UV-cross-linked hydrogels.
The disulfide-containing macromers and hydrogels exhibit H2O2-responsive degradation compared with the counterparts
synthesized by a dihydrazide monomer without disulfide moieties. The
cell viability under a high ROS environment can be well-maintained
under the protection of the disulfide containing hydrogels