Visual Framing of Science Conspiracy Videos: Integrating Machine Learning with Communication Theories to Study the Use of Color and Brightness

Recent years have witnessed an explosion of science conspiracy videos on the Internet, challenging science epistemology and public understanding of science. Scholars have started to examine the persuasion techniques used in conspiracy messages such as uncertainty and fear yet, little is understood about the visual narratives, especially how visual narratives differ in videos that debunk conspiracies versus those that propagate conspiracies. This paper addresses this gap in understanding visual framing in conspiracy videos through analyzing millions of frames from conspiracy and counter-conspiracy YouTube videos using computational methods. We found that conspiracy videos tended to use lower color variance and brightness, especially in thumbnails and earlier parts of the videos. This paper also demonstrates how researchers can integrate textual and visual features in machine learning models to study conspiracies on social media and discusses the implications of computational modeling for scholars interested in studying visual manipulation in the digital era. The analysis of visual and textual features presented in this paper could be useful for future studies focused on designing systems to identify conspiracy content on the Internet

Using Polymers as Crystal Inhibitors to Prevent the Crystallization of the Rotigotine Patch

This study aimed to enhance the stability of the Rotigotine (ROT) patch using polymers as crystal inhibitors. Three polymers (Poloxamer 188, Soluplus, TPGS) were selected as crystal inhibitors to formulate ROT patches with varying drug loadings (20%, 40%, 60%, and 80%, w/w). SEM and XRD analysis revealed that the Soluplus and Soluplus-TPGS groups with a high concentration (80%, w/w) of ROT could be stored at room temperature for at least 90 days without crystallization. Moreover, the crystallization nucleation time and growth rate were utilized to assess the ability of Poloxamer 188, Soluplus, and TPGS to hinder the formation of ROT crystals and slow down its crystallization rate. Molecular docking results elucidated the intermolecular forces between ROT and different polymers, revealing their mechanisms for crystal inhibition. The ROT-Soluplus-TPGS combination exhibited the lowest binding free energy (−5.3 kcal/mol), indicating the highest binding stability, thereby effectively reducing crystal precipitation. In vitro skin permeation studies demonstrated that ROT patches containing crystal inhibitors exhibited promising transdermal effects. With increasing ROT concentration, the cumulative drug permeation substantially increased, while the lag time was notably reduced. This study offers novel insights for the development of ROT patches