6,204 research outputs found
SecuCode: Intrinsic PUF Entangled Secure Wireless Code Dissemination for Computational RFID Devices
The simplicity of deployment and perpetual operation of energy harvesting
devices provides a compelling proposition for a new class of edge devices for
the Internet of Things. In particular, Computational Radio Frequency
Identification (CRFID) devices are an emerging class of battery-free,
computational, sensing enhanced devices that harvest all of their energy for
operation. Despite wireless connectivity and powering, secure wireless firmware
updates remains an open challenge for CRFID devices due to: intermittent
powering, limited computational capabilities, and the absence of a supervisory
operating system. We present, for the first time, a secure wireless code
dissemination (SecuCode) mechanism for CRFIDs by entangling a device intrinsic
hardware security primitive Static Random Access Memory Physical Unclonable
Function (SRAM PUF) to a firmware update protocol. The design of SecuCode: i)
overcomes the resource-constrained and intermittently powered nature of the
CRFID devices; ii) is fully compatible with existing communication protocols
employed by CRFID devices in particular, ISO-18000-6C protocol; and ii) is
built upon a standard and industry compliant firmware compilation and update
method realized by extending a recent framework for firmware updates provided
by Texas Instruments. We build an end-to-end SecuCode implementation and
conduct extensive experiments to demonstrate standards compliance, evaluate
performance and security.Comment: Accepted to the IEEE Transactions on Dependable and Secure Computin
Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy.
Androgen receptor (AR) signaling remains the major oncogenic pathway in prostate cancer (PCa). Androgen-deprivation therapy (ADT) is the principle treatment for locally advanced and metastatic disease. However, a significant number of patients acquire treatment resistance leading to castration resistant prostate cancer (CRPC). Epigenetics, the study of heritable and reversible changes in gene expression without alterations in DNA sequences, is a crucial regulatory step in AR signaling. We and others, recently described the technological advance Chem-seq, a method to identify the interaction between a drug and the genome. This has permitted better understanding of the underlying regulatory mechanisms of AR during carcinogenesis and revealed the importance of epigenetic modifiers. In screening for new epigenomic modifiying drugs, we identified SD-70, and found that this demethylase inhibitor is effective in CRPC cells in combination with current therapies. The aim of this review is to explore the role of epigenetic modifications as biomarkers for detection, prognosis, and risk evaluation of PCa. Furthermore, we also provide an update of the recent findings on the epigenetic key processes (DNA methylation, chromatin modifications and alterations in noncoding RNA profiles) involved in AR expression and their possible role as therapeutic targets
Thermodynamics of concentrated solid solution alloys
This paper reviews the three main approaches for predicting the formation of concentrated solid solution alloys (CSSA) and for modeling their thermodynamic properties, in particular, utilizing the methodologies of empirical thermo-physical parameters, CALPHAD method, and first-principles calculations combined with hybrid Monte Carlo/Molecular Dynamics (MC/MD) simulations. In order to speed up CSSA development, a variety of empirical parameters based on Hume-Rothery rules have been developed. Herein, these parameters have been systematically and critically evaluated for their efficiency in predicting solid solution formation. The phase stability of representative CSSA systems is then illustrated from the perspectives of phase diagrams and nucleation driving force plots of the σ phase using CALPHAD method. The temperature-dependent total entropies of the FCC, BCC, HCP, and σ phases in equimolar compositions of various systems are presented next, followed by the thermodynamic properties of mixing of the BCC phase in Al-containing and Ti-containing refractory metal systems. First-principles calculations on model FCC, BCC and HCP CSSA reveal the presence of both positive and negative vibrational entropies of mixing, while the calculated electronic entropies of mixing are negligible. Temperature dependent configurational entropy is determined from the atomic structures obtained from MC/MD simulations. Current status and challenges in using these methodologies as they pertain to thermodynamic property analysis and CSSA design are discussed
Close Pairs as Proxies for Galaxy Cluster Mergers
Galaxy cluster merger statistics are an important component in understanding
the formation of large-scale structure. Unfortunately, it is difficult to study
merger properties and evolution directly because the identification of cluster
mergers in observations is problematic. We use large N-body simulations to
study the statistical properties of massive halo mergers, specifically
investigating the utility of close halo pairs as proxies for mergers. We
examine the relationship between pairs and mergers for a wide range of merger
timescales, halo masses, and redshifts (0<z<1). We also quantify the utility of
pairs in measuring merger bias. While pairs at very small separations will
reliably merge, these constitute a small fraction of the total merger
population. Thus, pairs do not provide a reliable direct proxy to the total
merger population. We do find an intriguing universality in the relation
between close pairs and mergers, which in principle could allow for an estimate
of the statistical merger rate from the pair fraction within a scaled
separation, but including the effects of redshift space distortions strongly
degrades this relation. We find similar behavior for galaxy-mass halos, making
our results applicable to field galaxy mergers at high redshift. We investigate
how the halo merger rate can be statistically described by the halo mass
function via the merger kernel (coagulation), finding an interesting
environmental dependence of merging: halos within the mass resolution of our
simulations merge less efficiently in overdense environments. Specifically,
halo pairs with separations less than a few Mpc/h are more likely to merge in
underdense environments; at larger separations, pairs are more likely to merge
in overdense environments.Comment: 12 pages, 9 figures; Accepted for publication in ApJ. Significant
additions to text and two figures changed. Added new findings on the
universality of pair mergers and added analysis of the effect of FoF linking
length on halo merger
Imaging Hepatocellular Carcinoma With 68Ga-Citrate PET: First Clinical Experience.
While cross-sectional imaging with computed tomography (CT) and magnetic resonance imaging is the primary method for diagnosing hepatocellular carcinoma (HCC), they provide little biological insight into this molecularly heterogeneous disease. Nuclear imaging tools that can detect molecular subsets of tumors could greatly improve diagnosis and management of HCC. To this end, we conducted a patient study to determine whether HCC can be resolved using 68Ga-citrate positron emission tomography (PET). One patient with recurrent HCC was injected with 300 MBq of 68Ga-citrate and imaged with PET/CT 249 minutes post injection. Four (28%) of 14 hepatic lesions were avid for 68Ga-citrate. One extrahepatic lesion was not PET avid. The average maximum standardized uptake value (SUVmax) for the lesions was 7.2 (range: 6.2-8.4), while the SUVmax of the normal liver parenchyma was 4.7 and blood pool was 5.7. The avid lesions were not significantly larger than the quiescent lesions, and a prior contrast CT showed uniform enhancement among the lesions, suggesting that tumor signals are due to specific binding of the radiotracer to the transferrin receptor, rather than enhanced vascularity in the tumor microenvironment. Further studies are required in a larger patient cohort to verify the molecular basis of radiotracer uptake and the clinical utility of this tool
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