3,055 research outputs found
Collider Phenomenology of a Gluino Continuum
Continuum supersymmetry is a class of models in which the supersymmetric
partners together with part of the standard model come from a conformal sector,
broken in the IR near the TeV scale. Such models not only open new doors for
addressing the problems of the standard model, but also have unique signatures
at hadron colliders, which might explain why we have not yet seen any
superpartners at the LHC. Here we use gauge-gravity duality to model the
conformal sector, generate collider simulations, and finally analyze continuum
gluino signatures at the LHC. Due to the increase in the number of jets
produced the bounds are weaker than for the minimal supersymmetric standard
model with the same gluino mass threshold
No evidence of xenotropic murine leukemia virus-related virus transmission by blood transfusion from infected rhesus macaques
The discovery of xenotropic murine leukemia virus-related virus (XMRV) in human tissue samples has been shown to be due to virus contamination with a recombinant murine retrovirus. However, due to the unknown pathogenicity of this novel retrovirus and its broad host range, including human cell lines, it is important to understand the modes of virus transmission and develop mitigation and management strategies to reduce the risk of human exposure and infection. XMRV transmission was evaluated by whole-blood transfusion in rhesus macaques. Monkeys were infected with XMRV to serve as donor monkeys for blood transfers at weeks 1, 2, and 3 into naïve animals. The donor and recipient monkeys were evaluated for XMRV infection by nested PCR assays with nucleotide sequence confirmation, Western blot assays for development of virus-specific antibodies, and coculture of monkey peripheral blood mononuclear cells (PBMCs) with a sensitive target cell line for virus isolation. XMRV infection was demonstrated in the virus-injected donor monkeys, but there was no evidence of virus transmission by whole-blood transfusion to naïve monkeys based upon PCR analysis of PBMCs using XMRV-specific gag and env primers, Western blot analysis of monkey plasma up to 31 to 32 weeks after transfusion, and coculture studies using monkey PBMCs from various times after transfusion. The study demonstrates the lack of XMRV transmission by whole-blood transfusion during the acute phase of infection. Furthermore, analysis of PBMC viral DNA showed extensive APOBEC-mediated G-to-A hypermutation in a donor animal at week 9, corroborating previous results using macaques and supporting the possible restriction of XMRV replication in humans by a similar mechanism
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