CEREBRAL CIRCULATION AND COGNITION IN PATIENTS WITH CORONARY HEART DISEASE UNDERWENT CORONARY BYPASS OPERATION

Aim. To assess the  condition  of cerebral  circulation and  cognitive functions  in patients  with coronary  heart  disease (CHD), underwent  coronary  bypass  (CBG) operation  under on-pump  conditions and to evaluate the influence of citicoline on the higher brain functions at earlier and delayed periods post-surgery.Material and methods. In the Federal center  of cardiosurgery  (Krasnoyarsk city) 66 patients studied, with diagnosis CHD. Patients selected to 2 groups. Main group (n=36) as  a medium  for cerebral  neuroprotection we used  citicoline (Ceraxon): intravenous, 1 day before surgery, 1000 mg on 200 mL of saline, and then for 7 days after  surgery,  with further  intake  of  the  drug  900  mg/daily  for  2  months.  In comparison  group (n=30) there was no neuroprotection in peri-operation period. Results. By the 12th month after surgery, cognition returned  to baseline values. In controls,  by 12 months after CBG, cognition returned  to baseline  only by the test “visual memory” of 5 words (direct remembering).Conclusion. Neuroprotection by citicoline might be a method  for improvement of cognition  in patients  after  such  damaging  events  as  on-pump  operation,   and therefore make it to reach higher level of daily functioning of post-CBG patients

CEREBRAL CIRCULATION AND COGNITIVE STATUS OF CORONARY HEART DISEASE PATIENTS AFTER BYPASS SURGERY

Aim. To assess the condition of cerebral blood flow and cognitive functions in coronary heart disease (CHD) patients underwent on-pump coronary bypass surgery and to evaluate the influence of citicoline on the condition of higher cerebral functions during early and delayed follow-up after the surgery.Material and methods. At the Federal Center of Cardiovascular Surgery (Krasnoyarsk city), 66 patients investigated, with CHD. Patients were selected to two groups. In the main group (n=36) as a cerebral protector citicoline was used intravenously pre-operation, dosage 1000 mg on 200 mL 0,9% saline, and then 7 days after operation with further intake 900 mg daily for 2 months. Comparison group (n=30) did not undergo cerebroprotection in perioperational period.Results. By the 12th month after surgery, the parameters of cognition returned to baseline. In the controls, cognitive function returned to baseline only by the test “visual verbal memory” (direct reproduction).Conclusion. Neuroprotection by citicoline can be regarded as a method for improvement of cognitive functioning after such harming influences as on-pump surgery, and therefore to reach higher everyday functioning abilities after coronary bypass