Isolation and immunomodulatory activity of phytoconstituents of Lagenaria siceraria fruits

Not availabl

Question Answering System using Open Source Software

To get the answers of a question there are lots of search engine availbale. But the problem with the search engine is that instead of giving a straight forrward answer they usually gives the links/URL to the webpages which might have the answers. Instead of providing links Question Answering System will provide the straighforward answer to user\u27s question. Tasks intended by the project : • Takes question as an input from the user. • Analyses the sentiment behinds the question. • Lookover the information availbale in the knowledge base related to question. • Compute the answer of the question from the knowledge base. • Present the answer to the user if it is available. Strightforward answer will be very useful and time efficient and it is really helpful for the users who are using small screen devices, since in those devices it is very hard to find answers in webpage with lots of irrelevant content

The Road Ahead for Networking: A Survey on ICN-IP Coexistence Solutions

In recent years, the current Internet has experienced an unexpected paradigm shift in the usage model, which has pushed researchers towards the design of the Information-Centric Networking (ICN) paradigm as a possible replacement of the existing architecture. Even though both Academia and Industry have investigated the feasibility and effectiveness of ICN, achieving the complete replacement of the Internet Protocol (IP) is a challenging task. Some research groups have already addressed the coexistence by designing their own architectures, but none of those is the final solution to move towards the future Internet considering the unaltered state of the networking. To design such architecture, the research community needs now a comprehensive overview of the existing solutions that have so far addressed the coexistence. The purpose of this paper is to reach this goal by providing the first comprehensive survey and classification of the coexistence architectures according to their features (i.e., deployment approach, deployment scenarios, addressed coexistence requirements and architecture or technology used) and evaluation parameters (i.e., challenges emerging during the deployment and the runtime behaviour of an architecture). We believe that this paper will finally fill the gap required for moving towards the design of the final coexistence architecture.Comment: 23 pages, 16 figures, 3 table

Structure based de novo design of IspD inhibitors as anti-tubercular agents

Tuberculosis is one of the leading contagious diseases, caused by Mycobacterium tuberculosis. Despite improvements in anti-tubercular agents, it remains one of the most prevalent infectious diseases worldwide, responsible for a total of 1.6 million deaths annually. The emergence of multidrug resistant strains highlighted the need of discovering novel drug targets for the development of anti-tubercular agents. 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase (IspD) is an enzyme involved in MEP pathway for isoprenoid biosynthesis, which is considered an attractive target for the discovery of novel antibiotics for its essentiality in bacteria and absence in mammals. In the present study, we have employed structure based drug design approach to develop novel and potent inhibitors for IspD receptor. To explore binding affinity and hydrogen bond interaction between the ligand and active site of IspD receptor, docking studies were performed. ADMET and synthetic accessibility filters were used to screen designed molecules. Finally, ten compounds were selected and subsequently submitted for the synthesis and in vitro studies as IspD inhibitors

Optimization of Surface Orientation for High-Performance, Low-Power and Robust FinFET SRAM

We analyze the impact of surface orientation on stability and performance of FinFET SRAMs. We show that devices with proper orientations can improve static noise margin (SNM, 23-35%) and access time (22-33%) of 32nm FinFET SRAM compared to a design with devices of single (110) orientation

A Survey of Layer-Two Blockchain Protocols

After the success of the Bitcoin blockchain, came several cryptocurrencies and blockchain solutions in the last decade. Nonetheless, Blockchain-based systems still suffer from low transaction rates and high transaction processing latencies, which hinder blockchains' scalability. An entire class of solutions, called Layer-1 scalability solutions, have attempted to incrementally improve such limitations by adding/modifying fundamental blockchain attributes. Recently, a completely different class of works, called Layer-2 protocols, have emerged to tackle the blockchain scalability issues using unconventional approaches. Layer-2 protocols improve transaction processing rates, periods, and fees by minimizing the use of underlying slow and costly blockchains. In fact, the main chain acts just as an instrument for trust establishment and dispute resolution among Layer-2 participants, where only a few transactions are dispatched to the main chain. Thus, Layer-2 blockchain protocols have the potential to transform the domain. However, rapid and discrete developments have resulted in diverse branches of Layer-2 protocols. In this work, we systematically create a broad taxonomy of such protocols and implementations. We discuss each Layer-2 protocol class in detail and also elucidate their respective approaches, salient features, requirements, etc. Moreover, we outline the issues related to these protocols along with a comparative discussion. Our thorough study will help further systematize the knowledge dispersed in the domain and help the readers to better understand the field of Layer-2 protocols.Comment: 21 pages, 15 figures, 2 table

On the Feasibility of Profiling Electric Vehicles through Charging Data

Electric vehicles (EVs) represent the long-term green substitute for traditional fuel-based vehicles. To encourage EV adoption, the trust of the end-users must be assured. In this work, we focus on a recently emerging privacy threat of profiling and identifying EVs via the analog electrical data exchanged during the EV charging process. The core focus of our work is to investigate the feasibility of such a threat at scale. To this end, we first propose an improved EV profiling approach that outperforms the state-of-the-art EV profiling techniques. Next, we exhaustively evaluate the performance of our improved approach to profile EVs in real-world settings. In our evaluations, we conduct a series of experiments including 25032 charging sessions from 530 real EVs, sub-sampled datasets with different data distributions, etc. Our results show that even with our improved approach, profiling and individually identifying the growing number of EVs is not viable in practice; at least with the analog charging data utilized throughout the literature. We believe that our findings from this work will further foster the trust of potential users in the EV ecosystem, and consequently, encourage EV adoption.Comment: This is an extended version of our paper in VehicleSec 2023 (co-located with NDSS Symposium 2023), San Diego, C

Phase diagrams of Janus fluids with up-down constrained orientations

A class of binary mixtures of Janus fluids formed by colloidal spheres with the hydrophobic hemispheres constrained to point either up or down are studied by means of Gibbs ensemble Monte Carlo simulations and simple analytical approximations. These fluids can be experimentally realized by the application of an external static electrical field. The gas-liquid and demixing phase transitions in five specific models with different patch-patch affinities are analyzed. It is found that a gas-liquid transition is present in all the models, even if only one of the four possible patch-patch interactions is attractive. Moreover, provided the attraction between like particles is stronger than between unlike particles, the system demixes into two subsystems with different composition at sufficiently low temperatures and high densities.Comment: 10 pages, 6 figure