9 research outputs found
Nonlinear dynamics of a regenerative cutting process
- Author
- A. Ganguli
- A.L. Goldberger
- B. Krese
- D.B. Marghitu
- D.W. Wu
- D.W. Wu
- F. Taylor
- G. Litak
- G. Litak
- G. Litak
- G. Litak
- G. Stépán
- G. Stépán
- G.A. Gottwald
- G.A. Gottwald
- G.A. Gottwald
- G.A. Gottwald
- Grzegorz Litak
- Günter Radons
- H.E. Merrit
- I. Falconer
- I. Grabec
- I.N. Tansel
- J. Gradisek
- J. Gradisek
- J. Gradisek
- J. Warminski
- J.R. Pratt
- J.S. Richman
- L. Vela-Martínez
- M. Costa
- M. Costa
- M.S. Fofana
- P. Grassberger
- R.N. Arnold
- S.A. Tobias
- Sven Schubert
- T. Insperger
- X.S. Wang
- Y. Altintas
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Full text linkNew insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
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- Adams H.
- Adams P.M.
- Adarmes-Gómez A.
- Adarmes-Gómez A.D.
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Ahmad S.
- Akinyemi R.O.
- Al-Chalabi A.
- Alarcón-Martín Emilio
- Albert M.S.
- Albin R.L.
- Alcolea Daniel
- Alegret Montserrat
- Ali M.
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- Allende I.R.
- Alonso M.D.
- Alonso M.D.
- Alvarez I.
- Alvarez L.
- Amer-Ferrer G.
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- Amouyel Philippe
- Anastasiou A.
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Get PDFCharacterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
A search theoretic model of productivity, science and innovation
- Author
- Abernathy W.J.
- Baltagi B.H.
- Bental B.
- Blind K.
- Blind K.
- Deng Z.
- Evenson R.
- Evenson R.
- Foster R.N.
- Fung M.
- Ganguli P.
- Greene W.H.
- Griliches Z.
- Griliches Z.
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- Grossman G.
- Hagel J.
- Haitun S.D.
- Hsiao C.
- Jaffe A.
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- Segerstrom P.
- Sorenson O.
- Sornette D.
- Thumm N.
- Publication venue
- 'Wiley'
- Publication date
- 01/09/2007
- Field of study
No full textBuilding on macroeconomic research on technology searches in response to diminishing technological opportunities, we develop an industry‐level search theoretic model of productivity, knowledge sources, and innovation. We argue that increasing the use of science in technology development increases the novelty of ideas in the innovation search distribution and thus increases the likelihood of finding productivity improvements. We also propose that this relationship will hold outside the traditional science‐based industries (pharmaceuticals, chemicals), and that there is no similar relationship between productivity and non‐science patents. Random effect analyses of 32 US manufacturing industries during 1985–1997 support these hypotheses
Doublethink and scale mismatch polarize policies for an invasive tree
- Author
- A. Streit Krug
- A.C. Ganguli
- A.S. Garmestani
- B. Stewart-Koster
- B.C. Chaffin
- B.R. Coppedge
- B.W. van Wilgen
- B.W. Van Wilgen
- C.E. Bessey
- C.E. Owensby
- Caleb P. Roberts
- Craig R. Allen
- D. Pimentel
- D. Simberloff
- D. Simberloff
- D. Simberloff
- D. Simberloff
- D. Twidwell
- D. Twidwell
- D. Twidwell
- D. Twidwell
- D.M. Engle
- D.M. Meneguzzo
- D.R. Uden
- Daniel R. Uden
- Dirac Twidwell
- E.F. Ware
- E.R. Lawson
- G.S. Cumming
- H. Yokomizo
- J. Nel
- J.A. Crooks
- J.A. Crooks
- J.C. Frémont
- J.M. Briggs
- J.M. Briggs
- Kurt O. Reinhart
- L. Head
- L.L. Nackley
- M. Vilà
- M. Vítková
- M.J. Wittmann
- M.P. Carey
- P.A. Johnsgard
- R. Schneider
- R.F. Limb
- R.N. Mack
- R.S. Epanchin-Niell
- R.S. Epanchin-Niell
- R.S. Epanchin-Niell
- S.D. Fuhlendorf
- S.D. Fuhlendorf
- T.G. Bidwell
- V.J. Horncastle
- V.L. Simonsen
- V.M. Donovan
- Z. Ratajczak
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
No full textAlzheimer's disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci
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- Albert M.S.
- Albin R.L.
- Apostolova L.G.
- Arnold S.E.
- Baldwin C.T.
- Barber R.
- Barmada M.M.
- Barnes L.L.
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- Beekly D.
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- Field of study
No full text10.1371/journal.pone.0148717PLoS ONE112e014871
Pathophysiology of inflammatory bowel disease: the effect of inflammation on intestinal function
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- A. Dogan
- A. Geissler
- A. Mowat
- A. Nakazawa
- A. Ruhl
- A. Ruhl
- A. Saffar Al
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- A.J. Macpherson
- A.J. Ouellette
- A.M. Dvorak
- A.M. Dvorak
- A.M. Mowat
- A.O. Damiao
- A.O. Damiao
- A.O. Damiao
- B. Coulie
- B. Qiu
- B. Sharp
- B.S. Myers
- C. Bossone
- C. Fiocchi
- C. Lundqvist
- C.H. Tsai
- C.J. Woolf
- C.M. Evans
- C.N. Bernstein
- C.N. Bernstein
- C.R. Mantyh
- C.S. Kaetzel
- D. Kaiserlian
- D. Kaiserlian
- D. Kvale
- D. Maric
- D. R. Spriggs
- D. Sato
- D.A. O’Neil
- D.L. Vermillion
- D.L. Vermillion
- D.L. Vermillion
- D.M. McCafferty
- D.M. McCafferty
- D.M. McKay
- D.Y.E. Perey
- E. Cario
- E.B. Chang
- F. Castiglione
- F. Galeazzi
- F. Kern
- F. Lechin
- F. Porreca
- F. Shanahan
- G. Barbara
- G. Monteleone
- G. Olaison
- G. Zund
- G.T.J. Huang
- H. Schmitz
- H. Schmitz
- H.C. Jung
- I. Khan
- I.J. Cook
- J. Fallingborg
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- J. Malysz
- J. Meddings
- J.C. Kalff
- J.C. Oprins
- J.D. Soderholm
- J.F. Colombel
- J.J. Rumessen
- J.J. Rumessen
- J.K. Ramage
- J.L. Madara
- J.L. Madara
- J.M. Garrett
- J.M. Hosseini
- J.P. Hugot
- J.R. Gordon
- K. Croitoru
- K. Geboes
- K. Geboes
- K. Isozaki
- K. Tomita
- K.L. Cepek
- K.L. Williams
- L. Chang
- L. Grossi
- L. Lefrancois
- L. Marzio
- L. Mayer
- L. Mayer
- L. Mayer
- L. Thomsen
- L.A. Turnberg
- L.C. Yu
- L.M. Sollid
- M. Aihara
- M. Asahi
- M. Gue
- M. Kimura
- M. Kurokowa
- M. Merger
- M. Mourelle
- M. Takeuchi
- M. Watanabe
- M. Watanabe
- M.G. Blennerhassett
- M.H. Perdue
- M.J. Muller
- M.J.G. Farthing
- M.W. Turner
- N. Cerf-Bensussan
- N.K. Boughton-Smith
- N.R. Radojevic
- O. Palm
- O.N. Manousos
- P. Anton
- P. Blennerhassett
- P. Garside
- P. Garside
- P. Poussier
- P. Poussier
- P. Salomon
- P. Stashenko
- P. Vento
- P. Vento
- P.J. Roberts
- P.W. Bland
- R. Caprilli
- R. D’Inca
- R. Tomita
- R. Tomita
- R.B. Sartor
- R.B. Sartor
- R.H. Stead
- R.L. Deem
- R.N. Cunlirfe
- R.S. Blumberg
- S. Bjorck
- S. Evangelista
- S. Kernéis
- S. Levenstein
- S. Levenstein
- S. Lindgren
- S. Lindgren
- S.A. Mousa
- S.C. Ganguli
- S.E. Crowe
- S.E. Crowe
- S.K. Shaw
- S.M. Collins
- S.M. Collins
- S.M. Fish
- S.N. Reddy
- S.P. Colgan
- S.S. Rao
- T. Der
- T. Goodman
- T. Ohtoshi
- T.G. Moreels
- T.J. Standiford
- T.T. Pizarro
- T.T. Pizarro
- V. Annese
- V. Annese
- W.I. Khan
- W.J. Snape
- W.J. Snape Jr
- X.Y. Yio
- Y. Cong
- Y. Kubota
- Y. Li
- Y. Ogura
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2005
- Field of study
No full textReferences
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No full textNew insights into the genetic etiology of Alzheimer’s disease and related dementias
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
No full textCharacterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022, The Author(s)
Loss and Fractionation of Noble Gas Isotopes and Moderately Volatile Elements from Planetary Embryos and Early Venus, Earth and Mars
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- Publication date
- Field of study
No full text
