The Landmark Series: Appendiceal Primary Peritoneal Surface Malignancy

Appendiceal primary peritoneal surface malignancies are rare and include a broad spectrum of pathologies ranging from indolent disease to aggressive disease. As such, the data that drive the management of appendiceal peritoneal surface malignancies is generally not based on prospective clinical trial data, but rather consists of level 1 data based on retrospective studies and high-volume institutional experiences. Complete surgical debulking typically offers the best chance for long-term survival. This review highlights the landmark articles on which management of primary appendiceal peritoneal surface malignancies are based

On the Importance of Word Boundaries in Character-level Neural Machine Translation

Neural Machine Translation (NMT) models generally perform translation using a fixed-size lexical vocabulary, which is an important bottleneck on their generalization capability and overall translation quality. The standard approach to overcome this limitation is to segment words into subword units, typically using some external tools with arbitrary heuristics, resulting in vocabulary units not optimized for the translation task. Recent studies have shown that the same approach can be extended to perform NMT directly at the level of characters, which can deliver translation accuracy on-par with subword-based models, on the other hand, this requires relatively deeper networks. In this paper, we propose a more computationally-efficient solution for character-level NMT which implements a hierarchical decoding architecture where translations are subsequently generated at the level of words and characters. We evaluate different methods for open-vocabulary NMT in the machine translation task from English into five languages with distinct morphological typology, and show that the hierarchical decoding model can reach higher translation accuracy than the subword-level NMT model using significantly fewer parameters, while demonstrating better capacity in learning longer-distance contextual and grammatical dependencies than the standard character-level NMT model

The Role of Palliative Surgery for Malignant Bowel Obstruction and Perforation in Advanced Microsatellite Instability-High Colorectal Carcinoma in the Era of Immunotherapy: Case Report.

The role of palliative surgery in the management of acute complications in patients with disseminated malignancy remains controversial given the complexity of assessing acute surgical risk and long-term oncologic outcome. With the emergence of checkpoint blockade immunotherapy, there appears to be an increasing role for historically palliative procedures as a bridge to systemic immunotherapy. This is especially evident in advanced microsatellite instability-high (MSI-H) colorectal cancer where malignant obstruction and fistula formation are more common and where immunotherapy with checkpoint blockade (anti-PD-1/PD-L1, anti-CTLA-4) has a high response rate with potential for favorable oncologic outcomes. We present a series of three patients with MSI-H metastatic colorectal cancer complicated by malignant bowel obstruction and fistula formation, who having progressed on standard chemotherapy, underwent palliative intervention as a bridge to immune checkpoint blockade with durable and clinically meaningful anti-cancer responses. These cases highlight the need to re-evaluate the role of historically palliative operations in the setting of disease progression for immunotherapy-responsive tumors

The Landmark Series: Appendiceal Primary Peritoneal Surface Malignancy

Appendiceal primary peritoneal surface malignancies are rare and include a broad spectrum of pathologies ranging from indolent disease to aggressive disease. As such, the data that drive the management of appendiceal peritoneal surface malignancies is generally not based on prospective clinical trial data, but rather consists of level 1 data based on retrospective studies and high-volume institutional experiences. Complete surgical debulking typically offers the best chance for long-term survival. This review highlights the landmark articles on which management of primary appendiceal peritoneal surface malignancies are based

Chemotherapy-associated liver injury in colorectal cancer.

Patients with colorectal cancer (CRC) have benefited significantly from advances in multimodal treatment with significant improvements in long-term survival. More patients are currently being treated with surgical resection or ablation following neoadjuvant or adjuvant chemotherapy. However, several cytotoxic agents that are administered routinely have been linked to liver toxicities that impair liver function and regeneration. Recognition of chemotherapy-related liver toxicity emphasizes the importance of multidisciplinary planning to optimize care. This review aims to summarize current data on multimodal treatment concepts for CRC, provide an overview of liver damage caused by commonly administered chemotherapeutic agents, and evaluate currently suggested protective agents

Jumping and throwing performance in the World Masters' Athletic Championships 1975-2016

Participation and performance of elite age group athletes from 35-39 to 95-99 years competing in World Masters Athletics (WMA) Championships 1975-2016 were examined for throwing (discus, hammer, javelin and shot put) and jumping (high jump, long jump, pole vault and triple jump) events. Overall, 21,723 observations from 8,974 master athletes were analysed. A mixed regression model with sex, age group, calendar year and interactions terms (sex-age group; sex-year) defined as fixed effects was performed for each event separately. Performances over time were increasing overall for each event, with a cubic trend. Compared with women, men had better performances (e.g. in triple jump the estimated difference was 3.378 meters, p < 0.001). However, women improved their performance more than men across calendar years. Performances declined with age for each event (e.g. in triple jump, compared with age group 45-49 years, performance in age group 35-39 years was 1.041 meter better and in age group 85-89 years was 5.342 meter worse). In summary, performance in jumping and throwing events of WMA Championships improved across calendar years, whereas the decline of performance with age was dependent on sex and event