Six-fermion production and Higgs boson physics at future e+e−e^+ e^- colliders

The six-fermion production processes $e^+e^-\to q\bar q l^+ l^-\nu\bar\nu$, with all the lepton flavours and $q=u,d,c,s$, relevant to the study of the intermediate-mass Higgs boson at future $e^+e^-$ linear colliders, are analysed. A Monte Carlo program, taking into account the whole set of tree-level scattering amplitudes and the relevant radiative effects, is developed to provide integrated cross sections and generation of unweighted events. The complete calculation is compared with the available results of real Higgs production, and the opportunities of precision studies with event generation are discussed, demonstrating the relevance of a full six-fermion calculation. Numerical results for integrated cross sections with various kinematical cuts and including radiative effects are given and commented. In the analysis of event samples, several distributions are studied and found to be sensitive to the presence and to the properties of the Higgs boson.Comment: LaTeX, 27 pages, 13 figures included. Minor changes, final version to appear in Eur. Phys. J.

Experimental and ab-initio calculated vcd spectra of the first OH-stretching overtone of (1R)-(-) and (1S)-(+)-endo-borneol

The near infrared (NIR) absorption and NIR-vibrational circular dichroism (NIR-VCD) spectra of dilute solutions of the two enantiomers of endo-borneol have been measured in the first OH-stretching overtone region (1600–1300 nm). By density functional theory (DFT) we calculate mechanical parameters, i.e. the harmonic mechanical frequency and the anharmonicity constant for the OH stretching, and anharmonic electrical parameters; i.e. the dependence on OH-bond length of atomic polar tensors and atomic axial tensors. We evaluate transition integrals for the calculations of rotational and dipole strengths by Morse anharmonic wavefunctions depending on mechanical harmonic frequencies and mechanical anharmonicity parameters that are calculated ab initio. Experimental and calculated spectra compare quite well and this fact allows us to associate differently signed NIR-VCD features with different conformational states of the OH-bond. Absorption features for the fundamental and for the second overtone of the OH stretching are also compared with experiment

Electroweak Physics in Six-Fermion Processes at Future Colliders

Recent developments in the field of complete electroweak tree-level calculations for six-fermion final states in e+ e- collisions are briefly reviewed. Particular attention is given to top-quark and Higgs boson physics, which are items of primary importance at the Next Linear Collider. The relevance of electroweak backgrounds and finite-width effects is discussed, showing the importance of complete calculations for precision studies at the colliders operating in the TeV energy range.Comment: LaTeX (using npb style), 6 pages, 5 .eps figure

NIR-VCD, vibrational circular dichroism in the near-infrared: Experiments, theory and calculations

The first well documented experiments of Near Infrared Vibrational Circular Dichroism (NIR-VCD) were performed around 1975. We review the thirty year history of NIR-VCD, encompassing both instrumental development and theoretical/computational methods that allow interpretation of experimental spectra, harvesting useful structural information therefrom. We hope to stimulate interest in this still scarcely explored spectroscopy of chiral molecule

Harmonic and Anharmonic Features of IR and NIR Absorption and VCD Spectra of Chiral 4-X-[2.2]Paracyclophanes

The vibrational absorption spectra and vibrational circular dichroism (VCD) spectra of both enantiomers of 4-X-[2.2]paracyclophanes (X ) COOCD3, Cl, I) have been recorded for a few regions in the range of 900- 12000 cm-1. The analysis of the VCD spectra for the two IR regions, 900-1600 cm-1 and 2800-3200 cm-1, is conducted by comparing with DFT calculations of the corresponding spectra; the latter region reveals common motifs of vibrational modes for the three molecules for aliphatic CH stretching fundamentals, whereas in the mid-IR region, one is able to identify specific signatures arising from the substituent groups X. In the CH stretching region between 2900 and 2800 cm-1, we identify and interpret a group of three IR VCD bands due to HCH bending overtone transitions in Fermi resonance with CH stretching fundamental transitions. The analysis of the NIR region between 8000 and 9000 cm-1 for X ) COOCD3 reveals important features of the aromatic CH stretching overtones that are of value since the aromatic CH stretching fundamentals are almost silent. The intensifying of such overtones is attributed to electrical anharmonicity terms, which are evaluated here by ab initio methods and compared with literature data

At risk policy and early intervention programmes for underperforming students: Ensuring success?

Purpose - The purpose of this paper is to examine a University's at risk program and ask is the intervention strategy working? The program seeks to assist at risk students who may be experiencing difficulties transitioning, for example from school into university. The program also seeks to identify problems and suggest remediation strategies before attrition

Top-quark physics in six-quark final states at the Next Linear Collider

The processes of six-quark production with one $b\bar b$ pair are studied by means of a complete tree-level electroweak calculation. The top-quark signal is examined: the importance of electroweak backgrounds, of the order of 10% above the $t\bar t$ threshold and of about 30% of the purely electroweak signal at threshold, is further stressed by studying the dependence of the cross-section at threshold on the Higgs mass in the range between 100 GeV and 185 GeV, and finding variations of the order of 10%. In the study of some event-shape variables, a strong effect of initial-state radiation is found, in particular for the thrust distribution, which is studied for several centre-of-mass energies at the TeV scale. The effectiveness of cuts on the thrust for isolating QCD backgrounds, as pointed out by some authors, is confirmed also in the presence of electroweak backgrounds and initial-state radiation.Comment: LaTeX (using elsart.sty), 17 pages, 9 figures include

Vibrational Excitons in CH-Stretching Fundamental and Overtone Vibrational Circular Dichroism Spectra

A set of vibrational circular dichroism (VCD) spectra in the CH-stretching fundamental region for about twenty compounds belonging to the class of essential oils was empirically analyzed by the use of a sort of vibrational exciton mechanism, involving three centers. Through a general formula applicable to many coupled dipole oscillators, the rotational strengths of the previously identified vibrational excitons are evaluated. The results are then critically reviewed by the use of recent ab initio methodology, as applied to selected molecules of the original set. Further insight is gained by model calculations adding up the contribution of the coupling between electric dipole moments associated with normal mode behavior and that of the polarizability from polarizable groups. The former part is responsible for the excitonic behavior of the VCD spectra. For the same selected molecules we have also investigated whether some excitonic behavior is taking place in the second overtone region, and have concluded that this is not the case

Role of HMGB1 in Cutaneous Melanoma: State of the Art

High-mobility Group Box 1 (HMGB1) is a nuclear protein that plays a key role in acute and chronic inflammation. It has already been studied in several diseases, among them melanoma. Indeed, HMGB1 is closely associated with cell survival and proliferation and may be directly involved in tumor cell metastasis development thanks to its ability to promote cell migration. This research aims to assess the role of this molecule in the pathogenesis of human melanoma and its potential therapeutic role. The research has been conducted on the PubMed database, and the resulting articles are sorted by year of publication, showing an increasing interest in the last five years. The results showed that HMGB1 plays a crucial role in the pathogenesis of skin cancer, prognosis, and therapeutical response to therapy. Traditional therapies target this molecule indirectly, but future perspectives could include the development of new target therapy against HMGB1, thus adding a new approach to the therapy, which has often shown primary and secondary resistance. This could add a new therapy arm which has to be prolonged and specific for each patient