Additional file 7: of Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

The potential regulatory microRNAs. The results for each enriched gene set of predicted microRNA are listed in this excel. For each predicted microRNA, the information including the microRNA name, corresponding Gene Set ID, number of target genes of each microRNA, p value from hypergeometric test, p value adjusted by the multiple test adjustment, as well as target genes of each microRNA are listed. (XLSX 18 kb

Additional file 1: of Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

Differentially expressed genes identified by RNA-seq. The excel lists a total of 400 probes with the expression level changed, and those probes involved 321 differentially expressed genes between estrogen-treated intraluminal middle cerebral artery occlusion (MCAO) rat group and untreated MCAO rat group (p-value < 0.05). (XLSX 42 kb

Additional file 6: of Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

KEGG pathways enriched by differentially expressed genes. The results for each enriched KEGG pathway are listed in this excel. For each KEGG pathway, the information including KEGG pathway name, corresponding KEGG ID, number of genes in the gene set and also in the category, p value from hypergeometric test, p value adjusted by the multiple test adjustment, as well as genes in the pathway are listed. (XLSX 14 kb

Additional file 2: of Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

The interaction pairs of nodes in protein-protein interaction network. This excel presents 243 nodes and 590 interaction pairs (combined score > 0.4) in Fig. 1. In addition, it contains the combined score values of these 590 interaction pairs. (XLSX 61 kb

Additional file 3: of Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

The degrees of nodes in protein-protein interaction network. The excel describes the up/down-regulated status and degrees of 243 nodes in the PPI network. A total of 119 nodes were up-regulated genes and 124 nodes were down-regulated genes. The nodes degrees were ranged from 37 to 1. (XLSX 227 kb

Additional file 5: of Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

GO items enriched by up-regulated and down-regulated differentially expressed genes. The excel provides the following information in detail, including the names of 25 GO terms enriched by up-regulated genes and 18 GO terms enriched by down-regulated genes, and category, count, p value and adjusted p values for each GO term, as well as the genes list that enriched in GO term. (XLSX 16 kb

Mn₃O₄ Quantum Dots Supported on Nitrogen-Doped Partially Exfoliated Multiwall Carbon Nanotubes as Oxygen Reduction Electrocatalysts for High-Performance Zn–Air Batteries

Highly efficient and low-cost nonprecious metal electrocatalysts that favor a four-electron pathway for the oxygen reduction reaction (ORR) are essential for high-performance metal–air batteries. Herein, we show an ultrasonication-assisted synthesis method to prepare Mn₃O₄ quantum dots (QDs, ca. 2 nm) anchored on nitrogen-doped partially exfoliated multiwall carbon nanotubes (Mn₃O₄ QDs/N-p-MCNTs) as a high-performance ORR catalyst. The Mn₃O₄ QDs/N-p-MCNTs facilitated the four-electron pathway for the ORR and exhibited sufficient catalytic activity with an onset potential of 0.850 V (vs reversible hydrogen electrode), which is only 38 mV less positive than that of Pt/C (0.888 V). In addition, the Mn₃O₄ QDs/N-p-MCNTs demonstrated superior stability than Pt/C in alkaline solutions. Furthermore, a Zn–air battery using the Mn₃O₄ QDs/N-p-MCNTs cathode catalyst successfully generated a specific capacity of 745 mA h g^–1 at 10 mA cm^–2 without the loss of voltage after continuous discharging for 105 h. The superior ORR activity of Mn₃O₄ QDs/N-p-MCNTs can be ascribed to the homogeneous Mn₃O₄ QDs loaded onto the N-doped carbon skeleton and the synergistic effects of Mn₃O₄ QDs, nitrogen, and carbon nanotubes. The interface binding energy of −3.35 eV calculated by the first-principles density functional theory method illustrated the high stability of the QD-anchored catalyst. The most stable adsorption structure of O₂, at the interface between Mn₃O₄ QDs and the graphene layer, had the binding energy of −1.17 eV, greatly enhancing the ORR activity. In addition to the high ORR activity and stability, the cost of production of Mn₃O₄ QDs/N-p-MCNTs is low, which will broadly facilitate the real application of metal–air batteries