APPROACHES TO WEST SYNDROME TREATMENT: WHICH AEDs HELP BETTER?

Abstract. The study analyzes the effectiveness of short-term and long-term treatment of West syndrome with the help of different antiepileptic drugs (AEDs) (combined therapy with the inclusion of Tetracosactide in comparison with nonhormonal antiepileptic drugs). The RR risk ratio was calculated using Review Manager 5.2 (http://community.cochrane.org). A complete absence of seizures was considered as a favorable outcome. 150 children with confirmed West syndrome who received treatment at A.Yu.Ratner Pediatic Clinical Hospital №8 (Kazan, Russian Federation) were included into a retrospective observational study. 90 children treated with Tetracosactide in combination with AEDs were included into Group I. Group II consisted of 60 children who received any AEDs except Tetracosactide. The results showed that the effectiveness of Tetracosactide with complete absence of seizures as favorable outcome with short-term observation (at least 6 months) is higher than after treatment with other antiepileptic drugs in the absence of difference in safety. Long-term results of treatment (complete clinical remission during threeyears or more) did not have a significant difference.Keywords: West syndrome, Tetracosactide, antiepileptic drugs, epilepsy, effectiveness of treatment