New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

TRIBUNAL ARBITRAL DE LUIS ALBERTO DURAN VALENCIA VS. BANCOLOMBIA S.A., PORTAFOLIO DE INVERSIONES SURAMERICANA S.A., CEMENTOS DEL VALLE S.A., COMPAÑIA COLOMBIANA DE TABACO S.A., COMPAÑIA DE CEMENTO ARGOS S.A., INVERSIONES REACOL S.A., COMPAÑIA SURAMERICANA DE SEGUROS S.A. Y SURAMERICANA DE INVERSIONES S.A.

530

TRIBUNAL ARBITRAL DE GERZA LTDA. VS. BAVARIA S.A.

SN 2

TRIBUNAL ARBITRAL DE VISION Y ACCION IMAGEN S.A.S VS. TELEFONICA MOVILES COLOMBIA S.A.

222

TRIBUNAL ARBITRAL DE AUGUSTO ELISEO SAMPAYO NOGUERA VS. FIDUCIARIA DEL ESTADO S.A.

185

TRIBUNAL ARBITRAL DE AEROCALI S.A. VS. UNIDAD ADMINISTRATIVA ESPECIAL DE AERONAUTICA CIVIL (AEROCIVIL)

148

TRIBUNAL ARBITRAL DE CONAVI BANCO COMERCIAL Y DE AHORROS S.A. VS. CONCONCRETO S.A.

752

Metatranscriptome profiling of a specialized microbial consortium during the degradation of nixtamalized maize pericarp

Lignocellulose degradation by microbial consortia is multifactorial; hence, it must be analyzed from a holistic perspective. In this study, the temporal transcriptional activity of consortium PM-06, a nixtamalized maize pericarp (NMP) degrader, was determined and related to structural and physicochemical data to give insights into the mechanism used to degrade this substrate. Transcripts were described in terms of metabolic profile, carbohydrate-active enzyme (CAZyme) annotation, and taxonomic affiliation. The PM-06 gene expression pattern was closely related to the differential rates of degradation. The environmental and physiological conditions preceding high-degradation periods were crucial for CAZyme expression. The onset of degradation preceded the period with the highest degradation rate in the whole process, and in this time, several CAZymes were upregulated. Functional analysis of expressed CAZymes indicated that PM-06 overcomes NMP recalcitrance through modular enzymes operating at the proximity of the insoluble substrate. Increments in the diversity of expressed modular CAZymes occurred in the last stages of degradation where the substrate is more recalcitrant and environmental conditions are stressing. Taxonomic affiliation of CAZyme transcripts indicated that Paenibacillus macerans was fundamental for degradation. This microorganism established synergistic relationships with Bacillus thuringiensis for the degradation of cellulose and hemicellulose and with Microbacterium, Leifsonia, and Nocardia for the saccharification of oligosaccharides

Divulgación Científica No.3

La investigación constituye en sí misma un valioso instrumento para ser empleado por la sociedad, es mucho más que un objeto —sin abandonar lo que por naturaleza le compete: garantizar procesos de calidad—, puede entregar valiosa información sobre diferentes temas de interés, para avanzar en el análisis y propiciar la creación de redes de conocimiento.Research constitutes in itself a valuable instrument to be used by society, it is much more than an object —without abandoning what by nature is its responsibility: guaranteeing quality processes—, it can provide valuable information on different topics of interest, to advance in analysis and promote the creation of knowledge networks