The potential therapeutic effects of creatine supplementation on body composition and muscle function in cancer

Low muscle mass in individuals with cancer has a profound impact on quality of life and independence and is associated with greater treatment toxicity and poorer prognosis. Exercise interventions are regularly being investigated as a means to ameliorate treatment-related adverse effects, and nutritional/supplementation strategies to augment adaptations to exercise are highly valuable. Creatine (Cr) is a naturally-occurring substance in the human body that plays a critical role in energy provision during muscle contraction. Given the beneficial effects of Cr supplementation on lean body mass, strength, and physical function in a variety of clinical populations, there is therapeutic potential in individuals with cancer at heightened risk for muscle loss. Here, we provide an overview of Cr physiology, summarize the evidence on the use of Cr supplementation in various aging/clinical populations, explore mechanisms of action, and provide perspectives on the potential therapeutic role of Cr in the exercise oncology setting

General rules for bosonic bunching in multimode interferometers

We perform a comprehensive set of experiments that characterize bosonic bunching of up to 3 photons in interferometers of up to 16 modes. Our experiments verify two rules that govern bosonic bunching. The first rule, obtained recently in [1,2], predicts the average behavior of the bunching probability and is known as the bosonic birthday paradox. The second rule is new, and establishes a n!-factor quantum enhancement for the probability that all n bosons bunch in a single output mode, with respect to the case of distinguishable bosons. Besides its fundamental importance in phenomena such as Bose-Einstein condensation, bosonic bunching can be exploited in applications such as linear optical quantum computing and quantum-enhanced metrology.Comment: 6 pages, 4 figures, and supplementary material (4 pages, 1 figure

Global Alfven Wave Heating of the Magnetosphere of Young Stars

Excitation of a Global Alfven wave (GAW) is proposed as a viable mechanism to explain plasma heating in the magnetosphere of young stars. The wave and basic plasma parameters are compatible with the requirement that the dissipation length of GAWs be comparable to the distance between the shocked region at the star's surface and the truncation region in the accretion disk. A two-fluid magnetohydrodynamic plasma model is used in the analysis. A current carrying filament along magnetic field lines acts as a waveguide for the GAW. The current in the filament is driven by plasma waves along the magnetic field lines and/or by plasma crossing magnetic field lines in the truncated region of the disk of the accreting plasma. The conversion of a small fraction of the kinetic energy into GAW energy is sufficient to heat the plasma filament to observed temperatures.Comment: Submitted to ApJ, aheatf.tex, 2 figure

ROM-based quantum computation: Experimental explorations using Nuclear Magnetic Resonance, and future prospects

ROM-based quantum computation (QC) is an alternative to oracle-based QC. It has the advantages of being less ``magical'', and being more suited to implementing space-efficient computation (i.e. computation using the minimum number of writable qubits). Here we consider a number of small (one and two-qubit) quantum algorithms illustrating different aspects of ROM-based QC. They are: (a) a one-qubit algorithm to solve the Deutsch problem; (b) a one-qubit binary multiplication algorithm; (c) a two-qubit controlled binary multiplication algorithm; and (d) a two-qubit ROM-based version of the Deutsch-Jozsa algorithm. For each algorithm we present experimental verification using NMR ensemble QC. The average fidelities for the implementation were in the ranges 0.9 - 0.97 for the one-qubit algorithms, and 0.84 - 0.94 for the two-qubit algorithms. We conclude with a discussion of future prospects for ROM-based quantum computation. We propose a four-qubit algorithm, using Grover's iterate, for solving a miniature ``real-world'' problem relating to the lengths of paths in a network.Comment: 11 pages, 5 figure

Questioning the validity of non-extensive thermodynamics for classical Hamiltonian systems

We examine the non-extensive approach to the statistical mechanics of Hamiltonian systems with $H=T+V$ where $T$ is the classical kinetic energy. Our analysis starts from the basics of the formalism by applying the standard variational method for maximizing the entropy subject to the average energy and normalization constraints. The analytical results show (i) that the non-extensive thermodynamics formalism should be called into question to explain experimental results described by extended exponential distributions exhibiting long tails, i.e. $q$-exponentials with $q>1$, and (ii) that in the thermodynamic limit the theory is only consistent in the range $0\leq q\leq1$ where the distribution has finite support, thus implying that configurations with e.g. energy above some limit have zero probability, which is at variance with the physics of systems in contact with a heat reservoir. We also discuss the ($q$-dependent) thermodynamic temperature and the generalized specific heat.Comment: To appear in EuroPhysics Letter